Ivan Morace
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View article: Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury
Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury Open
To elucidate the physiologic function of renal globotriaosylceramide (Gb3/CD77), which up-to-date has been associated exclusively with Shiga toxin binding, we have analyzed renal function in Gb3-deficient mice. Gb3 synthase KO (Gb3S-/-) mi…
View article: Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals
Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals Open
Mammals synthesize, cell-type specifically, the diastereomeric hexosylceramides, β-galactosylceramide (GalCer) and β-glucosylceramide (GlcCer), which are involved in several diseases, such as sphingolipidosis, diabetes, chronic kidney dise…