Ivan Unksov
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View article: Marine-Inspired Antimicrobial Peptides Disrupt Gene Expression at the DNA Level
Marine-Inspired Antimicrobial Peptides Disrupt Gene Expression at the DNA Level Open
Genome mining of Streptomyces sp. H-KF8 combined with sequence engineering yielded two serum-stable, noncytotoxic, nonlytic antimicrobial peptides, L3 and L3-K. Initial studies in uropathogenic Escherichia coli suggested membrane effects a…
View article: DNA scission of non-His-containing ATCUN-like peptides
DNA scission of non-His-containing ATCUN-like peptides Open
Metallopeptides display interesting candidates for drug design from anti-cancer reagents to antimicrobials. We report the ability of non-His containing metallopeptides to perform scission of plasmid DNA exhibiting antibiotic resistance. Th…
View article: DNA Interaction with Head-to-Tail Associates of Cationic Surfactants Prevents Formation of Compact Particles
DNA Interaction with Head-to-Tail Associates of Cationic Surfactants Prevents Formation of Compact Particles Open
Cationic azobenzene-containing surfactants are capable of condensing DNA in solution with formation of nanosized particles that can be employed in gene delivery. The ratio of surfactant/DNA concentration and solution ionic strength determi…
View article: Interaction between cationic agents and small interfering RNA and DNA molecules
Interaction between cationic agents and small interfering RNA and DNA molecules Open
Azobenzene containing surfactant AzoTAB was used for investigation of binding in cationic- agent + nucleic acid in NaCl salt aqueous solutions. Two nucleic acids, macromolecular DNA and small interfering RNA, were examined upon the interac…