Ivan Nagaev
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View article: Endometriotic Tissue–derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis
Endometriotic Tissue–derived Exosomes Downregulate NKG2D-mediated Cytotoxicity and Promote Apoptosis: Mechanisms for Survival of Ectopic Endometrial Tissue in Endometriosis Open
Endometriosis, affecting 10% of women, is defined as implantation, survival, and growth of endometrium-like/endometriotic tissue outside the uterine cavity, causing inflammation, infertility, pain, and susceptibility to ovarian cancer. Des…
View article: NKG2D‐mediated cytotoxicity improves after primary surgery for high‐grade serous ovarian cancer
NKG2D‐mediated cytotoxicity improves after primary surgery for high‐grade serous ovarian cancer Open
Problem Tumors compromise the patients’ immune system to promote their own survival. We have previously reported that HGSC exosomes play a central role, downregulating NKG2D cytotoxicity. Primary surgery's effect on tumor exosomes and NKG2…
View article: Rift Valley Fever Virus Propagates in Human Villous Trophoblast Cell Lines and Induces Cytokine mRNA Responses Known to Provoke Miscarriage
Rift Valley Fever Virus Propagates in Human Villous Trophoblast Cell Lines and Induces Cytokine mRNA Responses Known to Provoke Miscarriage Open
The mosquito-borne Rift Valley fever (RVF) is a prioritised disease that has been listed by the World Health Organization for urgent research and development of counteraction. Rift Valley fever virus (RVFV) can cause a cytopathogenic effec…
View article: Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity
Enhanced local and systemic inflammatory cytokine mRNA expression in women with endometriosis evokes compensatory adaptive regulatory mRNA response that mediates immune suppression and impairs cytotoxicity Open
Problem Endometriosis is a disease characterized by ectopic implantation of endometrium and impaired immune responses. To explore its pathogenic mechanisms, we studied the local and systemic cytokine mRNA profiles and their role in the imm…
View article: Cytokine mRNA and protein expression by cell cultures of epithelial ovarian cancer—Methodological considerations on the choice of analytical method for cytokine analyses
Cytokine mRNA and protein expression by cell cultures of epithelial ovarian cancer—Methodological considerations on the choice of analytical method for cytokine analyses Open
Problem To get a comprehensive picture of cytokine expression in health and disease is difficult, cytokines are transiently and locally expressed, and protein analyses are burdened by biological modifications, technical issues, and sensiti…
View article: Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity
Lymphocyte profile and cytokine mRNA expression in peripheral blood mononuclear cells of patients with recurrent respiratory papillomatosis suggest dysregulated cytokine mRNA response and impaired cytotoxic capacity Open
Objectives Recurrent respiratory papillomatosis (RRP) is a relatively rare, chronic disease caused by Human Papilloma Virus (HPV) 6 and 11, and characterized by wart‐like lesions in the airway affecting voice and respiratory function. The …
View article: Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in <scp>CD</scp>8<sup>+</sup> T Cytotoxic Lymphocytes and <scp>CD</scp>19<sup>+</sup> B Lymphocytes in Rheumatoid Arthritis Responding to <scp>TNF</scp>‐<i>α</i> Inhibition
Melanocortin 2, 3 and 4 Receptor Gene Expressions are Downregulated in <span>CD</span>8<sup>+</sup> T Cytotoxic Lymphocytes and <span>CD</span>19<sup>+</sup> B Lymphocytes in Rheumatoid Arthritis Responding to <span>TNF</span>‐<i>α</i> Inhibition Open
Melanocortin signalling in leucocyte subsets elicits anti‐inflammatory and immune tolerance inducing effects in animal experimental inflammation. In man, however, the effects of melanocortin signalling in inflammatory conditions have scarc…
View article: Assessment of Cytokine mRNA Expression Profiles in Tumor Microenvironment and Peripheral Blood Mononuclear Cells of Patients with High-grade Serous Carcinoma of the Ovary
Assessment of Cytokine mRNA Expression Profiles in Tumor Microenvironment and Peripheral Blood Mononuclear Cells of Patients with High-grade Serous Carcinoma of the Ovary Open
Objective: Tumor establishment, metastatic spreading and poor survival in ovarian cancer is strongly associated with progressive derangement of the patient’s immune system. Accumulating evidence suggests that immune impairment is influence…
View article: IMPLANTATION OF A PERMANENT PACEMAKER IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION
IMPLANTATION OF A PERMANENT PACEMAKER IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION Open
The article presents a retrospective analysis of patients admitted to the Republican out-patient clinic of cardiology with a diagnosis of acute myocardial infarction, no later than 4 hours from the time of occurrence of symptoms of acute c…
View article: Resistin Gene Expression is Downregulated in <scp>CD</scp>4<sup>+</sup> T Helper Lymphocytes and <scp>CD</scp>14<sup>+</sup> Monocytes in Rheumatoid Arthritis Responding to <scp>TNF</scp>‐<i>α</i> Inhibition
Resistin Gene Expression is Downregulated in <span>CD</span>4<sup>+</sup> T Helper Lymphocytes and <span>CD</span>14<sup>+</sup> Monocytes in Rheumatoid Arthritis Responding to <span>TNF</span>‐<i>α</i> Inhibition Open
Rheumatoid arthritis ( RA ) is caused by complex interactions between immune cells and sustained by Th1 response cytokines. Resistin [resistance to insulin; (RETN) ] is an inflammatory cytokine, first discovered in murine adipocytes. In ma…