Ivan Nemazanyy
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View article: Myocardial disarray drives metabolic inefficiency in human cardiomyocytes
Myocardial disarray drives metabolic inefficiency in human cardiomyocytes Open
Adult cardiomyocytes are embedded within a highly organized myocardial microenvironment that imposes critical geometric cues essential for the alignment and distribution of organelles and the shaping of their unique, rectangular cellular m…
View article: Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions
Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions Open
View article: Lysosomal impairments in Pompe disease are associated with altered T cell homeostasis and intrinsic metabolic dysregulation
Lysosomal impairments in Pompe disease are associated with altered T cell homeostasis and intrinsic metabolic dysregulation Open
Pompe disease (PD) is a neuromuscular lysosomal storage disorder caused by mutations in the GAA gene, characterized by progressive glycogen accumulation in multiple tissues and autophagy and metabolic abnormalities. While immunological cha…
View article: G-quadruplex ligand RHPS4 compromises cellular radioresistance by inhibiting the mitochondrial adaptive response induced by ionizing irradiation
G-quadruplex ligand RHPS4 compromises cellular radioresistance by inhibiting the mitochondrial adaptive response induced by ionizing irradiation Open
A major challenge in radiotherapy is to enhance tumour cell sensitivity to radiation while minimizing damage to healthy tissues. Enhancing the effectiveness of radiotherapy can be achieved by combining irradiation with small radiosensitizi…
View article: Cellular NAD+ availability and redox state constrain developmental speed in the Drosophila eye
Cellular NAD+ availability and redox state constrain developmental speed in the Drosophila eye Open
The cellular and biochemical processes that limit the speed at which embryos develop, tissues form, and cells differentiate remain largely unknown. Using the speed of progression of a differentiation front in the developing eye of Drosophi…
View article: Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer
Loss of STARD7 Triggers Metabolic Reprogramming and Cell Cycle Arrest in Breast Cancer Open
Cancer cells adapt their metabolism to support aberrant cell proliferation. However, the functional link between metabolic reprogramming and cell cycle progression remains largely unexplored. Mitochondria rely on the transfer of multiple l…
View article: Interferon gamma induced-ACSL5 shapes the lipidome of kidney tubular cells
Interferon gamma induced-ACSL5 shapes the lipidome of kidney tubular cells Open
Acyl-CoA synthetase long-chain family (ACSL) enzymes are critical in the activation of long-chain fatty acid. To determine the regulatory mechanisms of ACSL5 and its biological functions within the kidney tubule, we generated transcriptomi…
View article: Regulation of immune cell metabolism by therapeutic normal IgG intravenous immunoglobulin
Regulation of immune cell metabolism by therapeutic normal IgG intravenous immunoglobulin Open
View article: mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins
mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins Open
View article: A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancer
A metabolic synthetic lethality of phosphoinositide 3-kinase-driven cancer Open
View article: The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage
The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage Open
The excessive production of extracellular matrix (ECM) and the metabolic adaptations in pancreatic ductal adenocarcinoma (PDAC) contribute individually to enhanced chemoresistance, dramatic tumor progression and dismal patient survival. Ho…
View article: ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development
ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development Open
Alterations inactivating the tumor suppressor gene PTEN drive the development of solid and hematologic cancers, such as T-cell acute lymphoblastic leukemia (T-ALL), in which phosphatase and tensin homolog (PTEN) loss defines poor-prognosis…
View article: The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis
The mitochondrial unfolded protein response promotes senescence in human microglia by increasing S-adenosylmethionine availability for polyamine synthesis Open
Mitochondria have developed a specialized mitochondrial unfolded protein response (UPR mt ) to maintain proteostasis and promote recovery under stress conditions. Research in simple organisms has demonstrated that UPR mt activation in glia…
View article: Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis
Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis Open
View article: Loss of STARD7 triggers metabolic reprogramming and cell cycle arrest in breast cancer
Loss of STARD7 triggers metabolic reprogramming and cell cycle arrest in breast cancer Open
Cancer cells adapt their metabolism to support aberrant cell proliferation. However, the functional link between metabolic reprogramming and cell cycle progression remains largely unexplored. Mitochondria rely on the transfer of multiple l…
View article: Targeted therapy for capillary-venous malformations
Targeted therapy for capillary-venous malformations Open
View article: Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8 <sup>+</sup> T cell memory development
Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8 <sup>+</sup> T cell memory development Open
Lactate–proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export from T cells. Here, we report that MCT1 is mandatory for the development of virus-specific CD8 + T cell memory. MCT1-deficient T cells were expose…
View article: A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism
A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism Open
View article: Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus
Mitochondrial dynamics and metabolic regulation control T cell fate in the thymus Open
Several studies demonstrated that mitochondrial dynamics and metabolic pathways control T cell fate in the periphery. However, little is known about their implication in thymocyte development. Our results showed that thymic progenitors (CD…
View article: Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability
Slc20a1 and Slc20a2 regulate neuronal plasticity and cognition independently of their phosphate transport ability Open
In recent years, primary familial brain calcification (PFBC), a rare neurological disease characterized by a wide spectrum of cognitive disorders, has been associated to mutations in the sodium (Na)-Phosphate (Pi) co-transporter SLC20A2 . …
View article: Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes
Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes Open
BACKGROUND: Diabetes is a major risk factor for atherosclerotic cardiovascular diseases with a 2-fold higher risk of cardiovascular events in people with diabetes compared with those without. Circulating monocytes are inflammatory effector…
View article: Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis
Mtfp1 ablation enhances mitochondrial respiration and protects against hepatic steatosis Open
View article: ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia
ACOX1-mediated peroxisomal fatty acid oxidation contributes to metabolic reprogramming and survival in chronic lymphocytic leukemia Open
View article: mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions
mTOR inhibition suppresses salinomycin-induced ferroptosis in breast cancer stem cells by ironing out mitochondrial dysfunctions Open
View article: Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy
Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy Open
View article: Cell plasticity in a mouse model of benign prostate hyperplasia drives amplification of androgen-independent epithelial cell populations sensitive to antioxidant therapy
Cell plasticity in a mouse model of benign prostate hyperplasia drives amplification of androgen-independent epithelial cell populations sensitive to antioxidant therapy Open
View article: Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition
Hemifacial myohyperplasia is due to somatic muscular PIK3CA gain-of-function mutations and responds to pharmacological inhibition Open
Hemifacial myohyperplasia (HFMH) is a rare cause of facial asymmetry exclusively involving facial muscles. The underlying cause and the mechanism of disease progression are unknown. Here, we identified a somatic gain-of-function mutation o…
View article: Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration
Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration Open
View article: S108: ATP CITRATE LYASE IS AN ESSENTIAL PLAYER OF THE METABOLIC REWIRING INDUCED BY PTEN LOSS DURING T-ALL DEVELOPMENT
S108: ATP CITRATE LYASE IS AN ESSENTIAL PLAYER OF THE METABOLIC REWIRING INDUCED BY PTEN LOSS DURING T-ALL DEVELOPMENT Open
Background: Alterations inactivating the tumor suppressor gene PTEN drive the development of distinct human pathologies, including solid and hematological cancers. In T-cell acute lymphoblastic leukemia (T-ALL), PTEN loss is commonly obser…
View article: Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture
Behavior, Neural Structure, and Metabolism in Adult Male Mice Exposed to Environmentally Relevant Doses of Di(2-ethylhexyl) Phthalate Alone or in a Phthalate Mixture Open
Differences in behavior of male mice exposed to environmental doses of phthalates were associated with differences in neural structure and metabolism, with possibly a key role of the kynurenine pathway of tryptophan metabolism in the effec…