Ivan Fan‐Ngai Hung
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View article: Antibiotic stewardship in suspected neutropenic fever (ASTERIC trial): a multicentre, type 1 hybrid effectiveness-implementation, stepped-wedge, randomised controlled trial study protocol
Antibiotic stewardship in suspected neutropenic fever (ASTERIC trial): a multicentre, type 1 hybrid effectiveness-implementation, stepped-wedge, randomised controlled trial study protocol Open
Introduction Neutropenic fever (NF) has a crude mortality rate of 3–18%. International guidelines recommend that all patients with NF receive ultrabroad-spectrum antibiotics (UBSAs) within 1 hour of emergency department (ED) registration. …
View article: Disease pattern and risk factors of antimicrobial resistance in patients with pneumococcal infection in the Hong Kong population
Disease pattern and risk factors of antimicrobial resistance in patients with pneumococcal infection in the Hong Kong population Open
Measures to reduce non-susceptible S. pneumoniae infections should focus on children and adolescents of school age. Despite the introduction of PCV13 in 2011, serotype 3 and AMR continued to threaten people in the community. Serotype 3-inf…
View article: Comparative effectiveness of combination therapy with nirmatrelvir-ritonavir and molnupiravir versus monotherapy with molnupiravir or nirmatrelvir-ritonavir in hospitalized COVID-19 patients: A target trial emulation study
Comparative effectiveness of combination therapy with nirmatrelvir-ritonavir and molnupiravir versus monotherapy with molnupiravir or nirmatrelvir-ritonavir in hospitalized COVID-19 patients: A target trial emulation study Open
The Health & Medical Research Fund Commissioned Research on COVID-19 (COVID1903010, COVID1903011; COVID19F01).
View article: Efficacy of Oseltamivir Against Seasonal Influenza H1N1 and the Efficacy of a Novel Combination Treatment In Vitro and In Vivo in Mouse Studies
Efficacy of Oseltamivir Against Seasonal Influenza H1N1 and the Efficacy of a Novel Combination Treatment In Vitro and In Vivo in Mouse Studies Open
Background Influenza surveillance and drug resistance testing have always been central to clinical efforts. Therefore, researching the virus characteristics and antiviral drugs is essential. Method The HA and NA activities were assessed in…
View article: Post-COVID-19 multimorbidity incidence by prior vaccination status in people with a pre-existing comorbidity: A population-based cohort study
Post-COVID-19 multimorbidity incidence by prior vaccination status in people with a pre-existing comorbidity: A population-based cohort study Open
COVID-19 infection is associated with an increased risk of multimorbidity in patients with pre-existing conditions. Full vaccination attenuates this risk substantially, highlighting its critical role in mitigating post-infection complicati…
View article: Correction: Riccò et al. Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options. Vaccines 2024, 12, 1317
Correction: Riccò et al. Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options. Vaccines 2024, 12, 1317 Open
The authors would like to make the following corrections to this published paper [...]
View article: Machine learning model for prediction of coronavirus disease 2019 within 6 months after three doses of BNT162b2 in Hong Kong
Machine learning model for prediction of coronavirus disease 2019 within 6 months after three doses of BNT162b2 in Hong Kong Open
An NN model integrating 15 clinical variables effectively identified individuals at low risk of COVID-19 following three doses of BNT162b2.
View article: Pneumococcal Vaccine Uptake in Adults Before and After Hospitalization for Pneumococcal Infections in Hong Kong, 2015 to 2024
Pneumococcal Vaccine Uptake in Adults Before and After Hospitalization for Pneumococcal Infections in Hong Kong, 2015 to 2024 Open
Background/Objectives: Vaccination is a key preventive measure against pneumococcal disease, but uptake rates remain low in high-risk populations. Limited information exists on pneumococcal vaccine uptake in individuals with a history of p…
View article: Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome (KICS): a case study
Kaposi sarcoma herpesvirus (KSHV) inflammatory cytokine syndrome (KICS): a case study Open
Our case report underscores the critical need for heightened awareness and recognition of KICS, given its rarity and unique clinical characteristics. By elucidating the complex interrelationships between Kaposi sarcoma, inflammatory cytoki…
View article: Potent antiviral activity of simnotrelvir against key epidemic SARS-CoV-2 variants with a high resistance barrier
Potent antiviral activity of simnotrelvir against key epidemic SARS-CoV-2 variants with a high resistance barrier Open
Simnotrelvir is an oral small-molecule antiviral agent targeting the 3C-like protease (3CL pro ) of SARS-CoV-2, proven effective against the Delta variant with favorable pharmacokinetics and safety in preclinical study. In this study, we f…
View article: The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors
The guided fire from within: intratumoral administration of mRNA-based vaccines to mobilize memory immunity and direct immune responses against pathogen to target solid tumors Open
We investigated a novel cancer immunotherapy strategy that effectively suppresses tumor growth in multiple solid tumor models and significantly extends the lifespan of tumor-bearing mice by introducing pathogen antigens into tumors via mRN…
View article: Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong
Post-acute sequelae of hospitalised COVID-19 re-infection compared with hospitalised first-time infection: a population-based retrospective cohort study in Hong Kong Open
Introduction COVID-19 infection is associated with post-acute adverse outcomes affecting multiple organ systems. Although preliminary studies have suggested that COVID-19 re-infection may have a cumulative effect on long-term outcome, diff…
View article: Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options
Respiratory Syncytial Virus: A WAidid Consensus Document on New Preventive Options Open
Background/Objectives: Respiratory syncytial virus (RSV) is a leading cause of respiratory infections, particularly affecting young infants, older adults, and individuals with comorbidities. Methods: This document, developed as a consensus…
View article: Aptamer-Mediated Electrochemical Detection of SARS-CoV-2 Nucleocapsid Protein in Saliva
Aptamer-Mediated Electrochemical Detection of SARS-CoV-2 Nucleocapsid Protein in Saliva Open
Gold standard detection of SARS-CoV-2 by reverse transcription quantitative PCR (RT-qPCR) can achieve ultrasensitive viral detection down to a few RNA copies per sample. Yet, the lengthy detection and labor-intensive protocol limit its eff…
View article: Efficacy of molnupiravir and interferon for the treatment of SARS‐CoV‐2 in golden Syrian hamster
Efficacy of molnupiravir and interferon for the treatment of SARS‐CoV‐2 in golden Syrian hamster Open
The mortality and hospitalization rate by COVID‐19 dropped significantly currently, but its seasonal outbreaks make antiviral treatment still vital. The mortality and hospitazation rate by COVID‐19 dropped significantly currently, but its …
View article: Effect of metabolic dysfunction‐associated steatotic liver disease on BNT162b2 immunogenicity against the severe acute respiratory syndrome coronavirus 2 <i>omicron</i> variant
Effect of metabolic dysfunction‐associated steatotic liver disease on BNT162b2 immunogenicity against the severe acute respiratory syndrome coronavirus 2 <i>omicron</i> variant Open
Background and Aim We aimed to investigate the effect of metabolic dysfunction‐associated steatotic liver disease (MASLD) on three‐dose BNT162b2 immunogenicity to the omicron variant. Methods Adult recipients of three doses of BNT162b2 wer…
View article: The significance of recurrent de novo amino acid substitutions that emerged during chronic SARS-CoV-2 infection: an observational study
The significance of recurrent de novo amino acid substitutions that emerged during chronic SARS-CoV-2 infection: an observational study Open
Theme-Based Research Scheme [T11/709/21-N] of the Research Grants Council (See acknowledgements for full list).
View article: Baseline Gut Microbiota Was Associated with Long-Term Immune Response at One Year Following Three Doses of BNT162b2
Baseline Gut Microbiota Was Associated with Long-Term Immune Response at One Year Following Three Doses of BNT162b2 Open
Background: This study explored neutralizing IgG antibody levels against COVID-19 decline over time post-vaccination. We conducted this prospective cohort study to investigate the function of gut microbiota in the host immune response foll…
View article: Human‐induced pluripotent stem cell‐derived hepatocyte platform in modeling of <scp>SARS‐CoV</scp>‐2 infection
Human‐induced pluripotent stem cell‐derived hepatocyte platform in modeling of <span>SARS‐CoV</span>‐2 infection Open
Background and Aim Currently, SARS‐CoV‐2 is still spreading rapidly and globally. A large proportion of patients with COVID‐19 developed liver injuries. The human‐induced pluripotent stem cell (iPSC)‐derived hepatocytes recapitulate primar…
View article: Real-World Effectiveness and Safety of Tixagevimab–Cilgavimab: A Target Trial Emulation Study
Real-World Effectiveness and Safety of Tixagevimab–Cilgavimab: A Target Trial Emulation Study Open
Tixagevimab-cilgavimab was effective in reducing COVID-19 infection among immunocompromised patients during the Omicron wave. Findings were consistent among individuals who previously received three or more doses of COVID-19 vaccine, or ha…
View article: Comparative effectiveness and safety of BNT162b2 and CoronaVac in Hong Kong: A target trial emulation
Comparative effectiveness and safety of BNT162b2 and CoronaVac in Hong Kong: A target trial emulation Open
BNT162b2 has higher effectiveness among individuals aged ≥12 against COVID-19-related outcomes for SARS-CoV-2 omicron compared to CoronaVac, with almost 50% lower mortality risk.
View article: Proton pump inhibitors associated with severe COVID‐19 among two‐dose but not three‐dose vaccine recipients
Proton pump inhibitors associated with severe COVID‐19 among two‐dose but not three‐dose vaccine recipients Open
Background and Aim Proton pump inhibitors (PPIs) may increase the risk of COVID‐19 among non‐vaccinated subjects via various mechanisms, including gut dysbiosis. We aimed to investigate whether PPIs also affect the clinical outcomes of COV…
View article: Association between Gut Microbiota Composition and Long-Term Vaccine Immunogenicity following Three Doses of CoronaVac
Association between Gut Microbiota Composition and Long-Term Vaccine Immunogenicity following Three Doses of CoronaVac Open
Background: Neutralizing antibody level wanes with time after COVID-19 vaccination. We aimed to study the relationship between baseline gut microbiota and immunogenicity after three doses of CoronaVac. Methods: This was a prospective cohor…
View article: Disseminated Mycobacterium haemophilum infection in an immunocompromised host: A complex case with immune reconstitution inflammatory syndrome (IRIS) manifestation
Disseminated Mycobacterium haemophilum infection in an immunocompromised host: A complex case with immune reconstitution inflammatory syndrome (IRIS) manifestation Open
Background Mycobacterium haemophilum is a rare but significant opportunistic pathogen known to cause infections in immunocompromised individuals. Despite its low prevalence, disseminated infections with this organism can present diagnostic…