Ivan Osinnii
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View article: ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function
ER-misfolded proteins become sequestered with mitochondria and impair mitochondrial function Open
View article: Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation
Silencing of the ER and Integrative Stress Responses in the Liver of Mice with Error-Prone Translation Open
Translational errors frequently arise during protein synthesis, producing misfolded and dysfunctional proteins. Chronic stress resulting from translation errors may be particularly relevant in tissues that must synthesize and secrete large…
View article: Apralogs: Apramycin 5-<i>O</i>-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant
Apralogs: Apramycin 5-<i>O</i>-Glycosides and Ethers with Improved Antibacterial Activity and Ribosomal Selectivity and Reduced Susceptibility to the Aminoacyltransferase (3)-IV Resistance Determinant Open
Apramycin is a structurally unique member of the 2-deoxystreptamine class of aminoglycoside antibiotics characterized by a monosubstituted 2-deoxystreptamine ring that carries an unusual bicyclic eight-carbon dialdose moiety. Because of it…
View article: Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis
Ribosomal mistranslation leads to silencing of the unfolded protein response and increased mitochondrial biogenesis Open