Iván Ruminot
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View article: APOE genotype-dependent differences in human astrocytic energy metabolism
APOE genotype-dependent differences in human astrocytic energy metabolism Open
Introduction The main genetic risk factor for Alzheimer’s disease (AD) is the presence of the apolipoprotein E4 ( APOE4 ) allele. While APOE4 increases the risk of developing AD, the APOE2 allele is protective and APOE3 is risk-neutral. In…
View article: Lactate-carried Mitochondrial Energy Overflow
Lactate-carried Mitochondrial Energy Overflow Open
We addressed the question of mitochondrial lactate metabolism using genetically-encoded sensors. The organelle was found to contain a dynamic lactate pool that leads to dose- and time-dependent protein lactylation. In neurons, mitochondria…
View article: Enlightening brain energy metabolism
Enlightening brain energy metabolism Open
Brain tissue metabolism is distributed across several cell types and subcellular compartments, which activate at different times and with different temporal patterns. The introduction of genetically-encoded fluorescent indicators that are …
View article: Metabolic Recruitment in Brain Tissue
Metabolic Recruitment in Brain Tissue Open
Information processing imposes urgent metabolic demands on neurons, which have negligible energy stores and restricted access to fuel. Here, we discuss metabolic recruitment, the tissue-level phenomenon whereby active neurons harvest resou…
View article: Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype
Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype Open
Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung function due to thic…
View article: Inhibition of the sodium-dependent HCO <sub>3</sub> <sup>-</sup> transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype
Inhibition of the sodium-dependent HCO <sub>3</sub> <sup>-</sup> transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype Open
Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung function due to thic…
View article: CO<sub>2</sub>signalling mediates neurovascular coupling in the cerebral cortex
CO<sub>2</sub>signalling mediates neurovascular coupling in the cerebral cortex Open
Summary The mechanisms of neurovascular coupling remain incompletely understood. Here we show in experimental animal models that the neuronal activity-dependent increases in local cerebral blood flow in the somatosensory cortex are abolish…
View article: Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle
Astrocytes regulate brain extracellular pH via a neuronal activity-dependent bicarbonate shuttle Open
Brain cells continuously produce and release protons into the extracellular space, with the rate of acid production corresponding to the levels of neuronal activity and metabolism. Efficient buffering and removal of excess H + is essential…
View article: Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis
Energy Dynamics in the Brain: Contributions of Astrocytes to Metabolism and pH Homeostasis Open
Regulation of metabolism is complex and involves enzymes and membrane transporters, which form networks to support energy dynamics. Lactate, as a metabolic intermediate from glucose or glycogen breakdown, appears to play a major role as ad…
View article: Neuronal control of astrocytic respiration through a variant of the Crabtree effect
Neuronal control of astrocytic respiration through a variant of the Crabtree effect Open
Significance Neuronal activity is immediately followed by aerobic glycolysis, the partial oxidation of glucose to lactate in the presence of oxygen, a phenomenon that seems paradoxical because full oxidation of glucose to CO 2 would yield …
View article: Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue
Tight coupling of astrocyte energy metabolism to synaptic activity revealed by genetically encoded FRET nanosensors in hippocampal tissue Open
The potassium ion, K + , a neuronal signal that is released during excitatory synaptic activity, produces acute activation of glucose consumption in cultured astrocytes, a phenomenon mediated by the sodium bicarbonate cotransporter NBCe1 (…
View article: Our hungry brain: Which role do glial cells play for the energy supply?
Our hungry brain: Which role do glial cells play for the energy supply? Open
Our brain, which accounts for about 2 % of our body weight, uses up to 20 % of our total energy requirements. The supply with sufficient energetic substrates to all brain cells, which are very densely packed, in particular in the human bra…
View article: Proton Fall or Bicarbonate Rise
Proton Fall or Bicarbonate Rise Open
Glycolysis is the primary step for major energy production in the cell. There is strong evidence suggesting that glucose consumption and rate of glycolysis are highly modulated by cytosolic pH/[H(+)], but those can also be stimulated by an…