Ivan Wangsaputra
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View article: Identification of novel differentiation trajectories and gene network associations with ectopic pregnancy in fallopian tube epithelium
Identification of novel differentiation trajectories and gene network associations with ectopic pregnancy in fallopian tube epithelium Open
STUDY QUESTION Can network modelling of single-cell transcriptomic data identify cellular developmental trajectories of fallopian tube (FT) epithelium and reveal functional and pathological divergence from the endometrium? SUMMARY ANSWER A…
View article: Diagnosis of childhood and adolescent growth hormone deficiency using transcriptomic data
Diagnosis of childhood and adolescent growth hormone deficiency using transcriptomic data Open
Background Gene expression (GE) data have shown promise as a novel tool to aid in the diagnosis of childhood growth hormone deficiency (GHD) when comparing GHD children to normal children. The aim of this study was to assess the utility of…
View article: OR14-1 Preimplantation embryo development is associated with both birth size and post-natal growth and can predict adult cardiovascular risk
OR14-1 Preimplantation embryo development is associated with both birth size and post-natal growth and can predict adult cardiovascular risk Open
Background The link between birth-size, early childhood growth and later life cardiovascular (CV) risk is well recognised. The contribution to CV risk of growth and cell differentiation during pre-implantation embryo development is unknown…
View article: Network Approaches for Charting the Transcriptomic and Epigenetic Landscape of the Developmental Origins of Health and Disease
Network Approaches for Charting the Transcriptomic and Epigenetic Landscape of the Developmental Origins of Health and Disease Open
The early developmental phase is of critical importance for human health and disease later in life. To decipher the molecular mechanisms at play, current biomedical research is increasingly relying on large quantities of diverse omics data…
View article: Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation
Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation Open
STUDY QUESTION How does the human embryo breach the endometrial epithelium at implantation? SUMMARY ANSWER Embryo attachment to the endometrial epithelium promotes the formation of multinuclear syncytiotrophoblast from trophectoderm, which…
View article: The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity
The expression and activity of Toll-like receptors in the preimplantation human embryo suggest a new role for innate immunity Open
STUDY QUESTION Is the innate immunity system active in early human embryo development? SUMMARY ANSWER The pattern recognition receptors and innate immunity Toll-like receptor (TLR) genes are widely expressed in preimplantation human embryo…