Ivan Zanoni
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View article: Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3
Chronic sensing of host-derived lipids is an all-in-one signal that primes and activates NLRP3 Open
Summary Activation of the NLRP3 inflammasome leads to the production of bioactive interleukin (IL)-1β fostering atherosclerosis. The current dogma is that NLRP3 must be first primed by microbial stimuli, known as pathogen-associated molecu…
View article: DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells
DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells Open
The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information about extracellular nucleic acids. Here…
View article: Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype
Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype Open
Adjuvants are widely used to boost the immune response during vaccination protocols. Our group has previously reported that repeated intraperitoneal administration of alum in mice, known as adjuvant conditioning (AC), creates an immunosupp…
View article: Group 2 Innate lymphoid cells promote allograft survival by constraining and inducing anergy in alloreactive CD4<sup>+</sup>T cells
Group 2 Innate lymphoid cells promote allograft survival by constraining and inducing anergy in alloreactive CD4<sup>+</sup>T cells Open
Although solid organ transplant outcomes have dramatically improved over the last several decades, incomplete understanding of the immune interface between the donor organ and the recipient’s immune system has impaired our ability to induc…
View article: Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa
Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa Open
The gut virome is a complex community that exists in equilibrium with the host. Disruptions of this balance could drive the development of inflammatory diseases, such as inflammatory bowel disease (IBD). RNA editing, particularly A‐to‐I ed…
View article: Adjuvant conditioning shapes the adaptive immune response promoting immunotolerance via NLRP3/interleukin-1
Adjuvant conditioning shapes the adaptive immune response promoting immunotolerance via NLRP3/interleukin-1 Open
Although adjuvants typically enhance immune responses, we show that repeated alum administration-termed adjuvant conditioning (AC)-induces an immunosuppressive environment that delays allogeneic graft rejection by expanding myeloid-derived…
View article: Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype
Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype Open
Adjuvants are widely used to boost the immune response during vaccination protocols. Our group has previously reported that repeated intraperitoneal administration of alum in mice, known as adjuvant conditioning (AC), creates an immunosupp…
View article: The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members
The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members Open
Innate immunity relies on pattern recognition receptors (PRRs) to detect threats, including pathogens and damage-associated molecular patterns (DAMPs) from damaged cells. IFI16 behaves as a DAMP and activates Toll-like receptor 4 (TLR4)-me…
View article: Adjuvant conditioning shapes the adaptive immune response and promotes trained immunotolerance via NLRP3/IL-1
Adjuvant conditioning shapes the adaptive immune response and promotes trained immunotolerance via NLRP3/IL-1 Open
Trained immunity enhances responsiveness of the innate immune system upon restimulation. Although adjuvants are used to enhance immune responses, we showed that repeated administration of alum, termed adjuvant conditioning (AC), establishe…
View article: Effect of influenza vaccination on SARS‐CoV‐2 infection: Relationship between SARS‐CoV‐2 infection rates and effects of influenza vaccination
Effect of influenza vaccination on SARS‐CoV‐2 infection: Relationship between SARS‐CoV‐2 infection rates and effects of influenza vaccination Open
We read with interest the recent meta-analysis by Del Riccio et al. [1] showing that in a series of 14 prospective studies influenza vaccination is without effect on infections (8 studies), hospitalization (5 studies), and death from COVID…
View article: Kids’ noses resist COVID-19
Kids’ noses resist COVID-19 Open
Children resist COVID-19, and previous studies reported increased innate immunity in their upper airways. A new paper by Watkins et al. (https://doi.org/10.1084/jem.20230911) shows that the nasal mucosa of children is characterized by ofte…
View article: Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation
Interleukin-10 suppresses lipid metabolism-mediated intestinal inflammation Open
In a recent paper published in Nature, York et al. reported that the anti-inflammatory cytokine IL-10 regulates sphingolipid metabolism to limit NF-κB-mediated inflammation. Deletion of Il10 in mice, or genetic mutation of IL10 in humans, …
View article: Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis
Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID‐19: A systematic review and meta‐analysis Open
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) causes COVID‐19 and has brought a huge burden in terms of human lives. Strict social distance and influenza vaccination have been recommended to avoid co‐infections between influ…
View article: Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter
Host-derived oxidized phospholipids initiate effector-triggered immunity fostering lethality upon microbial encounter Open
Macrophages detect invading microorganisms via pattern recognition receptors that recognize pathogen-associated molecular patterns, or via sensing the activity of virulence factors that initiates effector-triggered immunity (ETI). Tissue d…
View article: Homodimeric Granzyme A Opsonizes <i>Mycobacterium tuberculosis</i> and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14
Homodimeric Granzyme A Opsonizes <i>Mycobacterium tuberculosis</i> and Inhibits Its Intracellular Growth in Human Monocytes via Toll-Like Receptor 4 and CD14 Open
Mycobacterium tuberculosis (Mtb)-specific γ9δ2 T cells secrete granzyme A (GzmA) protective against intracellular Mtb growth. However, GzmA-enzymatic activity is unnecessary for pathogen inhibition, and the mechanisms of GzmA-mediated prot…
View article: Quantitative cytofluorimetric analysis of mouse neutrophil extracellular traps
Quantitative cytofluorimetric analysis of mouse neutrophil extracellular traps Open
The release of neutrophil extracellular traps (NETs) has been involved in numerous infectious and non-infectious diseases. Nevertheless, quantitative analysis of NETs in vivo has been challenging. Here, we present a protocol for NET quanti…
View article: pSCoPE: Prioritized Single-Cell Proteomics (data for generating publication figures)
pSCoPE: Prioritized Single-Cell Proteomics (data for generating publication figures) Open
Major aims of single-cell proteomics include increasing the consistency, sensitivity, and depth of protein quantification, especially for proteins and modifications of biological interest. To simultaneously advance all these aims, we devel…