Iver Heron
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View article: Tetanus toxoid coverage as an indicator of serological protection against neonatal tetanus.
Tetanus toxoid coverage as an indicator of serological protection against neonatal tetanus. Open
Tetanus toxoid coverage in the CAR was lower than the prevalence of serological protection against neonatal tetanus. If this relationship holds for other countries, TT coverage estimates from the MICS may underestimate the extent to which …
View article: Bordetella pertussis and Chronic Cough in Adults
Bordetella pertussis and Chronic Cough in Adults Open
To evaluate Bordetella pertussis as a cause of persistent cough in adults, we examined 201 patients who had a cough for 2-12 weeks and no pulmonary disease. We obtained the following at presentation: medical history, chest radiograph, resp…
View article: Multivalent pneumococcal capsular polysaccharide conjugate vaccines employing genetically detoxified pneumolysin as a carrier protein
Multivalent pneumococcal capsular polysaccharide conjugate vaccines employing genetically detoxified pneumolysin as a carrier protein Open
A genetically detoxified pneumolysin, pneumolysoid (PLD), was investigated as a carrier protein for pneumococcal capsular polysaccharide (CPS). Such a CPS-PLD conjugate might provide additional protection against pneumococcal infections an…
View article: Immunodominant Domains Present on the<i>Bordetella pertussis</i>Vaccine Component Filamentous Hemagglutinin
Immunodominant Domains Present on the<i>Bordetella pertussis</i>Vaccine Component Filamentous Hemagglutinin Open
To identify immunologically important domains on filamentous hemagglutinin (FHA), a Bordetella pertussis protein included in new acellular pertussis vaccines (ACPVs), a series of monoclonal antibodies, sera from infants vaccinated with ACP…
View article: Identification of B-cell epitopes on the S4 subunit of pertussis toxin
Identification of B-cell epitopes on the S4 subunit of pertussis toxin Open
The main purpose of the present study was to identify B-cell epitopes on the S4 subunit of pertussis toxin (PT) by the synthetic peptide approach. Two strategies were followed: (i) screening of two series of overlapping peptides (12- and 2…
View article: Specificity of a protective memory immune response against Mycobacterium tuberculosis
Specificity of a protective memory immune response against Mycobacterium tuberculosis Open
We have investigated the memory T-cell immune response to Mycobacterium tuberculosis infection. C57BL/6J mice infected with M. tuberculosis were found to generate long-lived memory immunity which provided a heightened state of acquired res…
View article: Identification of murine T-cell epitopes on the S4 subunit of pertussis toxin
Identification of murine T-cell epitopes on the S4 subunit of pertussis toxin Open
The aim of the present study was to identify murine T-cell epitopes on pertussis toxin subunit S4. Six mouse strains with five different haplotypes at the H-2 locus were immunized with the pertussis toxin B oligomer. Lymph node lymphocytes…
View article: Proliferative responses and gamma interferon and tumor necrosis factor production by lymphocytes isolated from tracheobroncheal lymph nodes and spleen of mice aerosol infected with Bordetella pertussis
Proliferative responses and gamma interferon and tumor necrosis factor production by lymphocytes isolated from tracheobroncheal lymph nodes and spleen of mice aerosol infected with Bordetella pertussis Open
A group of mice was aerosol infected with live, virulent Bordetella pertussis bacteria. During a period of 7 weeks following the infection, with intervals of 1 week, lymphocytes were isolated from the tracheobroncheal lymph nodes (TBL) and…
View article: Identification of human T-cell epitopes on the S4 subunit of pertussis toxin
Identification of human T-cell epitopes on the S4 subunit of pertussis toxin Open
Ten adult humans were vaccinated with the Japanese acellular pertussis vaccine JNIH-3, containing detoxified pertussis toxin (PT), formaldehyde, and filamentous hemagglutinin. The vaccination induced a specific antibody response to PT and …
View article: The cell mediated and humoral immune response to vaccination with acellular and whole cell pertussis vaccine in adult humans
The cell mediated and humoral immune response to vaccination with acellular and whole cell pertussis vaccine in adult humans Open
The cell mediated immune response (CMI) against pertussis antigens following vaccination with the traditional Danish whole cell pertussis vaccine (WC-P) and the Japanese acellular pertussis vaccine (A-PV) JNIH-3 was studied in four adult h…
View article: Proteins released from Mycobacterium tuberculosis during growth
Proteins released from Mycobacterium tuberculosis during growth Open
Proteins secreted from Mycobacterium tuberculosis during growth are believed to be important for protective immunity against tuberculosis. We have investigated the growth of M. tuberculosis in an enriched liquid medium. The release of isoc…
View article: T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis
T-cell proliferative response to antigens secreted by Mycobacterium tuberculosis Open
An infection model of human tuberculosis was established with C57BL/6J mice. The lymphocyte proliferative responses to antigens from Mycobacterium tuberculosis were investigated during the course of infection and compared with results obta…
View article: Cloning, partial sequence, expression, and antigenic analysis of the filamentous hemagglutinin gene of Bordetella pertussis
Cloning, partial sequence, expression, and antigenic analysis of the filamentous hemagglutinin gene of Bordetella pertussis Open
The gene coding for the filamentous hemagglutinin (FHA), one of the main factors involved in mediating adherence of Bordetella pertussis to ciliated host cells, was cloned in Escherichia coli, and the 3,500-base-pair nucleotide sequence en…
View article: Monoclonal antibodies produced in BALB.B10 mice define new antigenic determinants in culture filtrate preparations of Mycobacterium tuberculosis
Monoclonal antibodies produced in BALB.B10 mice define new antigenic determinants in culture filtrate preparations of Mycobacterium tuberculosis Open
A panel of monoclonal antibodies were derived from BALB.B10 mice immunized with a culture filtrate from Mycobacterium tuberculosis H37Rv. Of these antibodies, 10 were examined more closely for antigen specificity and interspecies reactivit…
View article: Antibody responses against Mycobacterium tuberculosis in 11 strains of inbred mice: novel monoclonal antibody specificities generated by fusions, using spleens from BALB.B10 and CBA/J mice
Antibody responses against Mycobacterium tuberculosis in 11 strains of inbred mice: novel monoclonal antibody specificities generated by fusions, using spleens from BALB.B10 and CBA/J mice Open
Eleven strains of inbred mice were immunized with a culture filtrate of Mycobacterium tuberculosis H37Rv, and the quality of the antibody responses was determined by immunoblotting. The quantity of mycobacterial antigen used for each immun…
View article: Allergenic and blastogenic reactivity of three antigens from Mycobacterium tuberculosis in sensitized guinea pigs
Allergenic and blastogenic reactivity of three antigens from Mycobacterium tuberculosis in sensitized guinea pigs Open
Three antigens from a culture filtrate of Mycobacterium tuberculosis H37Rv were purified by affinity chromatography, using monoclonal antibodies. The molecular weights of the purified antigens are 17,000 to 19,000, 32,000 to 33,000, and 39…
View article: Double-antibody sandwich enzyme-linked immunosorbent assay for rapid detection of toxin-producing Corynebacterium diphtheriae
Double-antibody sandwich enzyme-linked immunosorbent assay for rapid detection of toxin-producing Corynebacterium diphtheriae Open
An enzyme-linked immunosorbent assay for determining the toxigenicity of Corynebacterium diphtheriae is presented. The assay uses hyperimmune horse diphtheria antitoxin as a capture antibody and mouse monoclonal diphtheria antitoxin as a d…
View article: Studies on the differentiation of T lymphocytes in sheep. I. Recognition of a sheep T-lymphocyte differentiation antigen by a monoclonal antibody T-80.
Studies on the differentiation of T lymphocytes in sheep. I. Recognition of a sheep T-lymphocyte differentiation antigen by a monoclonal antibody T-80. Open
The results presented in this paper demonstrate that a mouse IgM monoclonal antibody (T-80) recognizes an antigen on cells of the T-lymphocyte lineage of sheep. However, this antibody does not identify all T cells, as 10-20% of thymocytes …
View article: Corticosteroids decrease the expression of beta 2-microglobulin and histocompatibility antigens on human peripheral blood lymphocytes in vitro.
Corticosteroids decrease the expression of beta 2-microglobulin and histocompatibility antigens on human peripheral blood lymphocytes in vitro. Open
The in vitro effect of two different glucocorticoids (prednisolone and dexamethasone) on the expression of beta 2-microglobulin and HLA-A-A, -B and -C-antigens on the surface of cultured lymphocytes was measured by quantitative immunofluor…
View article: Enhanced expression of β <sub>2</sub> -microglobulin and HLA antigens on human lymphoid cells by interferon
Enhanced expression of β <sub>2</sub> -microglobulin and HLA antigens on human lymphoid cells by interferon Open
Mononuclear cells from the blood of healthy normal humans were kept in cultures under nonstimulating conditions for 16 hr in the presence or absence of human interferon. The relative quantities of HLA antigens and β 2 -microglobulin on the…
View article: Lymphocyte-mediated cytotoxicity in humans during revaccination with vaccinia virus
Lymphocyte-mediated cytotoxicity in humans during revaccination with vaccinia virus Open
Fifteen healthy human volunteers were revaccinated with vaccinia virus. Blood samples (4 to 7) were obtained during the 3 weeks after revaccination. Peripheral blood lymphocytes were washed extensively and tested for cytotoxicity against v…
View article: Effector cell involved in cell-mediated cytotoxicity to cells infected with herpes simplex virus type 1
Effector cell involved in cell-mediated cytotoxicity to cells infected with herpes simplex virus type 1 Open
Experiments were performed to analyze the characteristics of the effector cells involved in cell-mediated killing of herpes-infected fibroblasts. Effector cells were fractionated according to adherence and phagocytic properties, and lympho…
View article: Cell-mediated cytotoxicity to herpes-infected cells in humans: dependence on antibodies
Cell-mediated cytotoxicity to herpes-infected cells in humans: dependence on antibodies Open
Herpes simplex virus type 1 (HSV-1)-infected human skin fibroblasts were used as target cells in a 51Cr release assay, using peripheral blood mononuclear cells from HSV-seropositive and -seronegative donors as effector cells. Cytotoxicity …