Explanipedia

Precision arbovirus serology with a pan-arbovirus peptidome Open

William R. Morgenlander, Wan Ni Chia, Beatriz Parra, Daniel R. Monaco, Izabela Ragan , et al. · 2024

An omicron-specific neutralizing antibody test predicts neutralizing activity against XBB 1.5 Open

Stephen A. Varvel, Marzena Galdzicka, Stephanie Nystrom, Hong Liu, Ge Chen , et al. · 2024

Introduction Understanding the immune status of an individual using neutralizing antibody testing is complicated by the continued evolution of the SARS-CoV-2 virus. Previous work showed that assays developed against the wildtype strain of …

Integrating Veterinary Diagnostic Laboratories for Emergency Use Testing during Pandemics1 Open

Natasha Hodges, McKenzie N. Sparrer, Tyler Sherman, Treana Mayer, Danielle R. Adney , et al. · 2024

The SARS-CoV-2 pandemic showed limitations in human outbreak testing. Veterinary diagnostic laboratories (VDLs) possess capabilities to bolster emergency test capacity. Surveys from 26 participating VDLs found human SARS-CoV-2 testing was …

UV-C Light Intervention as a Barrier against Airborne Transmission of SARS-CoV-2 Open

Izabela Ragan, Jessie Perez, Wilson Davenport, Lindsay Hartson, Branden Doyle · 2024

Background: SARS-CoV-2 continues to impact human health globally, with airborne transmission being a significant mode of transmission. In addition to tools like vaccination and testing, countermeasures that reduce viral spread in indoor se…

UV-C Light Intervention as a Barrier against Airborne Transmission of SARS-CoV-2 Open

Izabela Ragan, Jessie Perez, Lindsay Hartson, Wilson Davenport, Branden Doyle · 2023

Background: SARS-CoV-2 continues to impact human health globally, with airborne transmission being a significant mode for transmission. In addition to tools like vaccination and testing, counter-measures that reduce viral spread in indoor …

UV-C Light Intervention as a Barrier against Airborne Transmission of SARS-CoV-2 Open

Izabela Ragan, Jessie Perez, Lindsay Hartson, Wilson Davenport, Branden Doyle · 2023

Background: SARS-CoV-2 continues to impact human health globally, with airborne transmission being a significant mode for transmission. In addition to tools like vaccination and testing, counter-measures that reduce viral spread in indoor …

SARS-CoV-2 surveillance in a veterinary health system provides insight into transmission risks Open

McKenzie N. Sparrer, Natasha Hodges, Izabela Ragan, Tyler Yamashita, Kirsten J. Reed , et al. · 2023

OBJECTIVE To investigate the prevalence and seropositivity of SARS-CoV-2 in companion and exotic animals in a veterinary healthcare system. SAMPLE A total of 341 animals were sampled by a combination of oral and nasal swabs. Serum from who…

Emerging Pathogen Threats in Transfusion Medicine: Improving Safety and Confidence with Pathogen Reduction Technologies Open

Márcia Cardoso, Izabela Ragan, Lindsay Hartson, Raymond P. Goodrich · 2023

Emerging infectious disease threats are becoming more frequent due to various social, political, and geographical pressures, including increased human–animal contact, global trade, transportation, and changing climate conditions. Since blo…

Emerging Pathogen Threats in Transfusion Medicine and the Role of Pathogen Reduction Technologies Open

Márcia Cardoso, Izabela Ragan, Lindsay Hartson, Raymond P. Goodrich · 2023

Emerging infectious disease threats are becoming more frequent due to various social, political and geographical pressures including increased human-animal contact, global trade, transportation and changing climate conditions. As a result,…

Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV light Open

Izabela Ragan, Lindsay Hartson, Elizabeth J. Sullivan, Richard A. Bowen, Raymond P. Goodrich · 2023

Background Monkeypox virus has recently emerged from endemic foci in Africa and, since October 20, 2022, more than 73,000 human infections have been reported by the CDC from over 100 countries that historically have not reported monkeypox …

A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models Open

Giulietta Maruggi, Corey P. Mallett, Jason W. Westerbeck, Tiffany Chen, Giuseppe Lofano , et al. · 2022

Potential Use for Serosurveillance of Feral Swine to Map Risk for Anthrax Exposure, Texas, USA Open

Rachel M. Maison, Courtney F. Pierce, Izabela Ragan, Vienna R. Brown, Michael J. Bodenchuk , et al. · 2021

Anthrax is a disease of concern in many mammals, including humans. Management primarily consists of prevention through vaccination and tracking clinical-level observations because environmental isolation is laborious and bacterial distribu…

Preliminary Evaluation of a Recombinant Rift Valley Fever Virus Glycoprotein Subunit Vaccine Providing Full Protection against Heterologous Virulent Challenge in Cattle Open

William C. Wilson, Bonto Faburay, Jessie D. Trujillo, Izabela Ragan, Sun-Young Sunwoo , et al. · 2021

Rift Valley fever virus (RVFV) is a mosquito-borne zoonotic pathogen that causes periodic outbreaks of abortion in ruminant species and hemorrhagic disease in humans in sub-Saharan Africa. These outbreaks have a significant impact on veter…

A Whole Virion Vaccine for COVID-19 Produced via a Novel Inactivation Method and Preliminary Demonstration of Efficacy in an Animal Challenge Model Open

Izabela Ragan, Lindsay Hartson, Taru S. Dutt, Andrés Obregón‐Henao, Rachel M. Maison , et al. · 2021

The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease and other emerging diseases. Several novel methods for preparing vaccine candidates are currently undergoin…

A whole virion vaccine for COVID-19 produced via a novel inactivation method: results from animal challenge model studies Open

Izabela Ragan, Lindsay Hartson, Taru S. Dutt, Andrés Obregón‐Henao, Rachel M. Maison , et al. · 2020

The COVID-19 pandemic has generated intense interest in the rapid development and evaluation of vaccine candidates for this disease and other emerging diseases. Several novel methods for preparing vaccine candidates are currently undergoin…

Experimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in cats Open

Angela M. Bosco‐Lauth, Airn E. Hartwig, Stephanie Porter, Paul Gordy, Mary Nehring , et al. · 2020

Significance SARS-CoV-2 is an emerging pathogen that has already had catastrophic consequences on the health and well-being of people worldwide. As a zoonotic virus, the implications for animal populations are largely unknown. This manuscr…

Pathogen reduction of SARS-CoV-2 virus in plasma and whole blood using riboflavin and UV light Open

Izabela Ragan, Lindsay Hartson, Heather F. Pidcoke, Richard E. Bowen, Raymond P. Goodrich · 2020

Riboflavin and UV light effectively reduced the titer of SARS-CoV-2 to the limit of detection in human plasma and by 3.30 ± 0.26 on average in whole blood. Two clades of SARS-CoV-2 have been described and questions remain about whether exp…

Pathogenesis, transmission and response to re-exposure of SARS-CoV-2 in domestic cats Open

Angela M. Bosco‐Lauth, Airn E. Hartwig, Stephanie Porter, Paul Gordy, Mary Nehring , et al. · 2020

The pandemic caused by SARS-CoV-2 has reached nearly every country in the world with extraordinary person-to-person transmission. The most likely original source of the virus was spillover from an animal reservoir and subsequent adaptation…

Pathogen Reduction of SARS-CoV-2 Virus in Plasma and Whole Blood using Riboflavin and UV Light Open

Izabela Ragan, Lindsay Hartson, Heather F. Pidcoke, Richard E. Bowen, Raymond P. Goodrich · 2020

BACKGROUND Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has recently been identified as the causative agent for Coronavirus Disease 2019 (COVID-19). The ability of this agent to be transmitted by blood transfusion has not b…

Inactivation of severe acute respiratory syndrome coronavirus 2 in plasma and platelet products using a riboflavin and ultraviolet light‐based photochemical treatment Open

Shawn D. Keil, Izabela Ragan, Susan Yonemura, Lindsay Hartson, Nicole K. Dart , et al. · 2020

Background and Objective Severe acute respiratory distress syndrome coronavirus‐2 (SARS‐CoV‐2), the causative agent of coronavirus disease 2019 (COVID‐19), is a member of the coronavirus family. Coronavirus infections in humans are typical…

Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection Open

Danielle R. Adney, Michael Letko, Izabela Ragan, Dana Scott, Neeltje van Doremalen , et al. · 2019

In 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) emerged. To date, more than 2300 cases have been reported, with an approximate case fatality rate of 35%. Epidemiological investigations identified dromedary camels as the so…

Evaluation of Fluorescence Microsphere Immunoassay for Detection of Antibodies to Rift Valley Fever Virus Nucleocapsid Protein and Glycoproteins Open

Izabela Ragan, A. Sally Davis, D. Scott McVey, Jüergen A. Richt, Raymond R.R. Rowland , et al. · 2018

Rift Valley fever virus (RVFV) is a mosquito-borne, zoonotic virus that infects ruminants, including cattle, sheep, goats, camels, and buffalo. Multiplexing diagnostic assays that can simultaneously detect antibodies against multiple RVFV …

Importance of differentiating infected and vaccinated animals (DIVA) in outbreaks and the potential of Luminex-based fluorescence microsphere immunoassay for Rift Valley fever diagnosis Open

Johanna F. Lindahl, Izabela Ragan, Rachel Palinski, Bernard Bett, W. David Wilson , et al. · 2015

Successful conservative management of suspected Fournier’s gangrene in cats: three cases Open

Heather H Vaske, Izabela Ragan, Kenneth R. Harkin, Karen Lee, Sarah E Hicks · 2015

Case series summary Three cats with suspected Fournier’s gangrene had an acute onset of clinical signs and bloodwork changes consistent with sepsis. All cases had similar progression of wounds that were managed without aggressive surgical …

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