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View article: Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ<sup>9</sup>‐tetrahydrocannabinol in older patients with poor appetite
Population pharmacokinetic modelling revealed large variability in oromucosal absorption of Δ<sup>9</sup>‐tetrahydrocannabinol in older patients with poor appetite Open
Aim Cannabis‐based medicines are gaining interest and being explored for new therapeutic indications, many of which commonly affect older medical patients. As most previous studies of the population pharmacokinetics of cannabinoids have be…
View article: Population pharmacokinetics of Δ9-tetrahydrocannabinol and an active metabolite in older patients with poor appetite
Population pharmacokinetics of Δ9-tetrahydrocannabinol and an active metabolite in older patients with poor appetite Open
View article: The Predictive Role of C-Reactive Protein, Leukocyte Cell Count, and Soluble Urokinase Plasminogen Activator Receptor for Pulmonary Sequelae in Hospitalized COVID-19 Survivors: A Prospective Single-Center Cohort Study
The Predictive Role of C-Reactive Protein, Leukocyte Cell Count, and Soluble Urokinase Plasminogen Activator Receptor for Pulmonary Sequelae in Hospitalized COVID-19 Survivors: A Prospective Single-Center Cohort Study Open
Background: Pulmonary function impairment significantly affects quality of life, work ability, and healthcare utilization. Among patients with COVID-19, respiratory symptoms vary in severity. This study aimed to assess whether biomarkers r…
View article: The appetite stimulating effect and safety of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in older patients with poor appetite: A triple-blinded, randomized, placebo-controlled, cross-over trial
The appetite stimulating effect and safety of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in older patients with poor appetite: A triple-blinded, randomized, placebo-controlled, cross-over trial Open
In older patients with poor appetite, CBM administered buccally at two time points at the same day, with each dose containing 8.1 mg THC and 7.5 mg CBD, did not improve caloric intake compared to placebo. The observed safety parameters sug…
View article: Prospective and External Validation of Machine Learning Models for Short- and Long-Term Mortality in Acutely Admitted Patients Using Blood Tests
Prospective and External Validation of Machine Learning Models for Short- and Long-Term Mortality in Acutely Admitted Patients Using Blood Tests Open
Background: Predicting mortality in emergency departments (EDs) using machine learning models presents challenges, particularly in balancing simplicity with performance. This study aims to develop models that are both simple and effective …
View article: The Predictive Role of C-Reactive Protein, Leukocyte Cell Count, and Soluble Urokinase Plasminogen Activator Receptor for Pulmonary Sequelae in Hospitalized COVID-19 Survivors: A Prospective Single-Center Cohort Study
The Predictive Role of C-Reactive Protein, Leukocyte Cell Count, and Soluble Urokinase Plasminogen Activator Receptor for Pulmonary Sequelae in Hospitalized COVID-19 Survivors: A Prospective Single-Center Cohort Study Open
Background Pulmonary function impairment has profound effects on patient quality of life, working ability, and healthcare utilization. Among individuals suffering from Coronavirus disease (COVID-19), a range of severity in respiratory symp…
View article: Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests.
Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests. Open
The application of machine learning (ML) models in emergency departments (EDs) to predict short- and long-term mortality encounters challenges, particularly in balancing simplicity with performance. This study addresses this gap by develop…
View article: Development and validation of prognostic machine learning models for short- and long-term mortality among acutely admitted patients based on blood tests
Development and validation of prognostic machine learning models for short- and long-term mortality among acutely admitted patients based on blood tests Open
Several scores predicting mortality at the emergency department have been developed. However, all with shortcomings either simple and applicable in a clinical setting, with poor performance, or advanced, with high performance, but clinical…
View article: Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests
Prospective and External Validation of Prognostic Machine Learning Models for Short- and Long-Term Mortality Among Acutely Admitted Patients Based on Blood Tests Open
View article: Appetite stimulation with cannabis‐based medicine and methods for assessment of glomerular filtration in older patients with medical illness: A study protocol
Appetite stimulation with cannabis‐based medicine and methods for assessment of glomerular filtration in older patients with medical illness: A study protocol Open
Background and aim Malnutrition in older patients is linked to poor appetite. Cannabis‐based medicine may have orexigenic properties in older patients, but this has to our knowledge never been investigated. In older patients, uncertainty a…
View article: Development and validation of prognostic machine learning models for short- and long-term mortality among acutely hospitalized patients.
Development and validation of prognostic machine learning models for short- and long-term mortality among acutely hospitalized patients. Open
Background: Several scores predicting mortality at the emergency department have been developed. However, all with shortcomings either simple and applicable in a clinical setting, with poor performance, or advanced, with high performance, …
View article: Soluble Urokinase Plasminogen Activator Receptor and Venous Thromboembolism in COVID‐19
Soluble Urokinase Plasminogen Activator Receptor and Venous Thromboembolism in COVID‐19 Open
Background Venous thromboembolism (VTE) contributes significantly to COVID‐19 morbidity and mortality. The urokinase receptor system is involved in the regulation of coagulation. Levels of soluble urokinase plasminogen activator receptor (…
View article: Soluble Urokinase Plasminogen Activator Receptor as a Decision Marker for Early Discharge of Patients with COVID-19 Symptoms in the Emergency Department
Soluble Urokinase Plasminogen Activator Receptor as a Decision Marker for Early Discharge of Patients with COVID-19 Symptoms in the Emergency Department Open
View article: suPAR Cut-Offs for Risk Stratification in Patients With Symptoms of COVID-19
suPAR Cut-Offs for Risk Stratification in Patients With Symptoms of COVID-19 Open
Objectives: Elevated soluble urokinase Plasminogen Activator Receptor (suPAR) is a biomarker associated with adverse outcomes. We aimed to investigate the associations between plasma suPAR levels (testing the cut-offs ⩽4, 4-6, and ⩾6 ng/mL…
View article: Low levels of the prognostic biomarker suPAR are predictive of mild outcome in patients with symptoms of COVID-19 - a prospective cohort study
Low levels of the prognostic biomarker suPAR are predictive of mild outcome in patients with symptoms of COVID-19 - a prospective cohort study Open
OBJECTIVE To examine if baseline soluble urokinase plasminogen activator receptor (suPAR) can predict whether patients with COVID-19 symptoms will need mechanical ventilation during a 14-day follow-up. Furthermore, to examine differences i…
View article: First reported human bloodstream infection with Vagococcus lutrae
First reported human bloodstream infection with Vagococcus lutrae Open
Vagococcus lutrae belongs to the Vagococcus genus; it is possible to isolate vagococci from marine hosts, contaminated food and soil. To our knowledge, this is the first case of bloodstream infection with V. lutrae and…