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View article: Real‑world efficacy and safety data of immune checkpoint inhibitors in Turkish patients with metastatic melanoma: A Turkish oncology group retrospective study
Real‑world efficacy and safety data of immune checkpoint inhibitors in Turkish patients with metastatic melanoma: A Turkish oncology group retrospective study Open
In recent years, significant success has been achieved in the treatment of metastatic melanoma with the use of immune checkpoint inhibitors (ICIs), and it resulted in a remarkable increase in patient survival. However, there are only a few…
View article: Evaluation of Changes in Clinicopathological Features and Prognosis in Patients with Thyroid Cancer
Evaluation of Changes in Clinicopathological Features and Prognosis in Patients with Thyroid Cancer Open
Background: In this study, we evaluated the changes in clinicopathological features and prognosis in patients with thyroid cancer in the last two decades using the Surveillance, Epidemiology, and End Results Database (SEER) data. Methods: …
View article: The efficacy of second-line chemotherapy in the management of classic and iatrogenic Kaposi sarcoma: An analysis of real-world data
The efficacy of second-line chemotherapy in the management of classic and iatrogenic Kaposi sarcoma: An analysis of real-world data Open
Kaposi sarcoma (KS) is a rare angioproliferative malignancy linked to human herpesvirus 8 infection. While systemic therapy is often unnecessary for classic and iatrogenic KS, advanced cases may require chemotherapy. This study aims to eva…
View article: Rechallenge of trastuzumab-based therapy in HER2-positive breast cancer patients who progressed after lapatinib plus capecitabine
Rechallenge of trastuzumab-based therapy in HER2-positive breast cancer patients who progressed after lapatinib plus capecitabine Open
Data regarding the use of rechallenge trastuzumab (RTmab)-based therapies in the management of heavily pretreated patients with HER2-positive breast cancer (BC) in the literature are limited. This study aimed to evaluate the efficacy of tr…
View article: Comparison of efficacy and safety of 5-FU or capecitabine combined with cisplatin and docetaxel (mDCF and mDCX) as a first-line chemotherapy regimen in her 2-negative metastatic gastric cancer patients: A retrospective study
Comparison of efficacy and safety of 5-FU or capecitabine combined with cisplatin and docetaxel (mDCF and mDCX) as a first-line chemotherapy regimen in her 2-negative metastatic gastric cancer patients: A retrospective study Open
The prognosis of metastatic gastric cancer (GC) is poor, with a median survival time of less than a year. Capecitabine is a prodrug, metabolized by thymidine phosphorylase to its cytotoxic metabolite (5-FU). Few studies have compared capec…
View article: Disease characteristics and prognostic factors of colorectal cancer patients with bone metastasis: A real-world data from Turkey
Disease characteristics and prognostic factors of colorectal cancer patients with bone metastasis: A real-world data from Turkey Open
Background: Bone metastasis is rarely seen in colorectal cancer (CRC) patients, and there is insufficient data available regarding such cases. The study aimed to identify the prognostic factors and characteristics associated with overall s…
View article: Is there any diagnostic value of serum caveolin-1 levels on the determination of pancreatic adenocarcinoma?
Is there any diagnostic value of serum caveolin-1 levels on the determination of pancreatic adenocarcinoma? Open
Background: Caveolin-1 (CAV-1) is a vital component in cancer pathogenesis, as its expression determines the survival of patients with cancer. This study investigates CAV-1 serum levels in pancreatic adenocarcinoma (PA) patients and their …
View article: Comparative analysis of doublet chemotherapy regimens plus bevacizumab in patients with recurrent ovarian cancer
Comparative analysis of doublet chemotherapy regimens plus bevacizumab in patients with recurrent ovarian cancer Open
Among all gynecological malignancies, ovarian cancer is the predominant cause of mortality. Hence, various chemotherapy protocols have been established for managing metastatic ovarian cancer cases. The present study aimed to assess and com…
View article: The effect of parity, breastfeeding history, and duration on clinical and pathological characteristics of breast cancer patients
The effect of parity, breastfeeding history, and duration on clinical and pathological characteristics of breast cancer patients Open
Breast cancer is seen at a later age in patients who are parous than those who have never given birth. Patients who are parous and have breastfed tend to present with a higher stage of the disease.
View article: Efficacy and outcomes of systemic chemotherapy in posttransplant and immunosuppression associated Kaposi sarcoma: Twenty years experience of a tertiary cancer center
Efficacy and outcomes of systemic chemotherapy in posttransplant and immunosuppression associated Kaposi sarcoma: Twenty years experience of a tertiary cancer center Open
Kaposi sarcoma is a malignant angioproliferative disease, and human herpesvirus-8 plays a major role in its etiology. Iatrogenic Kaposi sarcoma (IKS) can occur in patients undergoing immunosuppressive therapy. The treatment strategy for pa…
View article: Termination of trastuzumab in HER2-positive metastatic breast cancer patients who received trastuzumab beyond progression
Termination of trastuzumab in HER2-positive metastatic breast cancer patients who received trastuzumab beyond progression Open
The purpose of the study was to assess the prognosis of HER2-positive metastatic breast cancer patients who received trastuzumab beyond progression and investigate the predictors of complete response. HER2-positive metastatic breast cancer…
View article: Predictors of response in EGFR-mutant metastatic non-small cell lung cancer patients treated with tyrosine kinase inhibitors
Predictors of response in EGFR-mutant metastatic non-small cell lung cancer patients treated with tyrosine kinase inhibitors Open
Background: The goal of the study was to evaluate the efficacy of tyrosine kinase inhibitors in patients with epidermal growth factor receptor ( EGFR )-mutant metastatic non-small cell cancer and to determine the factors that predict objec…
View article: Clinicopathologic characteristics and prognostic factors in patients with male breast cancer: A single tertiary center experience
Clinicopathologic characteristics and prognostic factors in patients with male breast cancer: A single tertiary center experience Open
Background: The goal of this study was to assess the clinicopathologic characteristics and prognostic variables in men with breast cancer (BC). Methods: Clinical features, pathological characteristics, stage at diagnosis, and therapy data …
View article: Single-agent temozolomide as salvage therapy in heavily pretreated metastatic sarcoma patients
Single-agent temozolomide as salvage therapy in heavily pretreated metastatic sarcoma patients Open
Background: Treatment options for patients with metastatic sarcoma are limited. The goal of this study was to investigate the effectiveness of temozolomide in pretreated patients with soft tissue sarcoma. Methods: We recorded the pathologi…
View article: Outcomes of the patients with metastatic male breast cancer
Outcomes of the patients with metastatic male breast cancer Open
Background: The goal of this research is to investigate the clinical characteristics and prognosis of men with metastatic breast cancer (mMBC). Methods: A retrospective analysis of the data of 28 patients was conducted. Kaplan–Meier and Co…
View article: Immune checkpoint inhibitors: Assessment of the performance and the agreement of iRECIST, irRC, and irRECIST
Immune checkpoint inhibitors: Assessment of the performance and the agreement of iRECIST, irRC, and irRECIST Open
Introduction: Immunotherapy has become more widely accepted and used by medical oncologists. Radiologists face challenges in assessing tumor response and becoming more involved in the management of treatment. We aimed to assess the agreeme…
View article: Efficacy and safety of sorafenib in adult metastatic osteosarcoma patients
Efficacy and safety of sorafenib in adult metastatic osteosarcoma patients Open
Background: There are limited data on the efficacy of targeted therapy in metastatic osteosarcoma. The goal of this study was to assess the effectiveness of sorafenib in adult patients with heavily pretreated metastatic osteosarcoma. Metho…
View article: Prognostic Factors Influencing Progression-Free Survival in HER2-Positive Metastatic Breast Cancer Patients Who Were Treated With A Combination of Lapatinib and Capecitabine
Prognostic Factors Influencing Progression-Free Survival in HER2-Positive Metastatic Breast Cancer Patients Who Were Treated With A Combination of Lapatinib and Capecitabine Open
These results have demonstrated the effectiveness of lapatinib plus capecitabine in metastatic HER2-positive breast cancer patients. Furthermore, unfavorable prognostic factors for progression-free survival were shown to be hormone-negativ…
View article: Demographic and Clinical Features of Patients with Metastatic Breast Cancer: A Retrospective Multicenter Registry Study of the Turkish Oncology Group
Demographic and Clinical Features of Patients with Metastatic Breast Cancer: A Retrospective Multicenter Registry Study of the Turkish Oncology Group Open
This multicenter registry study aims to analyze time-related changes in the treatment patterns and outcome of patients with metastatic breast cancer (MBC) over a ten-year period. Correlations between demographic, prognostic variables and s…
View article: Weekly paclitaxel treatment in the first-line therapy of classic Kaposi sarcoma: A real-life study
Weekly paclitaxel treatment in the first-line therapy of classic Kaposi sarcoma: A real-life study Open
Kaposi sarcoma is an angioproliferative disease associated with human herpes virus 8 infection. Classic Kaposi sarcoma (CKS) usually develops in older age. Although CKS often does not require systemic therapy, systemic therapy can be admin…
View article: The Significance of Preoperative Computed Tomography Features in the Prediction of Overall Survival in Gastric Cancer: A Retrospective Analysis
The Significance of Preoperative Computed Tomography Features in the Prediction of Overall Survival in Gastric Cancer: A Retrospective Analysis Open
R1 resection status is associated with poor OS in GC. CT features, including the tumor's longest dimension and the number of pathological LNs, can predict R1 resection status.
View article: Outcomes and prognostic factors in metastatic renal cell carcinoma patients with brain metastases
Outcomes and prognostic factors in metastatic renal cell carcinoma patients with brain metastases Open
S Background: To evaluate the outcomes and prognostic factors in patients with brain metastatic renal cell carcinoma (bmRCC). Methods: The data of 322 patients with metastatic renal cell carcinoma, taken between 2012 and 2020, were retrosp…
View article: Fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in the first-line treatment of metastatic gastric cancer: A single-center experience
Fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in the first-line treatment of metastatic gastric cancer: A single-center experience Open
Objective: The median survival time for metastatic gastric cancer that has a poor prognosis is usually shorter than 1 year. The fluorouracil, oxaliplatin, and docetaxel (FLOT) regimen is observed to be effective in the neo-adjuvant treatme…
View article: Distributions and prognostic effects of ABO/Rh blood groups in patients with HER2/neu positive gastric and gastroesophageal junction cancer
Distributions and prognostic effects of ABO/Rh blood groups in patients with HER2/neu positive gastric and gastroesophageal junction cancer Open
Background: The aim of study was to look at ABO/Rh blood types frequency and prognostic significance in patients with HER2/neu positive gastric cancer. Methods: The study was designed retrospectively. Clinicopathological characteristics, t…
View article: High-dose chemotherapy followed by autologous stem cell transplantation for adult patients With first relapse of Ewing’s sarcoma: A single institution experience
High-dose chemotherapy followed by autologous stem cell transplantation for adult patients With first relapse of Ewing’s sarcoma: A single institution experience Open
The prognosis of patients with Ewing’s sarcoma family of tumors (ESFT) relapse is poor; the 5-year overall survival (OS) is 13%. We evaluated the effectivity of high-dose therapy (HDT) with autologous stem cell transplantation (ASCT) in ad…
View article: Toxicity management and efficacy of carboplatin desensitization therapy for recurrent epithelial ovarian carcinoma: A real-world study
Toxicity management and efficacy of carboplatin desensitization therapy for recurrent epithelial ovarian carcinoma: A real-world study Open
Epithelial Ovarian cancer (EOC) is the most lethal gynecologic cancer worldwide. Carboplatin (CP) is the main chemotherapeutic agent in the treatment of ovarian cancer. However, the development of a hypersensitivity reaction (HSR) in 10% t…