Jan A. Bruijn
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View article: Explainability of a Deep Learning-Based Classification Model for Antineutrophil Cytoplasmic Autoantibody–Associated Glomerulonephritis
Explainability of a Deep Learning-Based Classification Model for Antineutrophil Cytoplasmic Autoantibody–Associated Glomerulonephritis Open
We present the first DL-based computational pipeline for classifying ANCA-GN kidney biopsies as per the Berden classification. XAI techniques helped us to make the decision-making criteria of the DL accessible for renal pathologists, poten…
View article: Rapid liquid biopsy assessment through gene profiling from the kidney biopsy transport medium: a technical validation and a proof-of-concept pilot study
Rapid liquid biopsy assessment through gene profiling from the kidney biopsy transport medium: a technical validation and a proof-of-concept pilot study Open
Rapid diagnosis is pivotal in kidney disease for timely and precision therapy. Conventional microscopic and molecular assessments from biopsy tissues rely on extra sample processing, making same-day diagnosis impractical. Therefore, we int…
View article: MIF Increases sFLT1 Expression in Early Uncomplicated Pregnancy and Preeclampsia
MIF Increases sFLT1 Expression in Early Uncomplicated Pregnancy and Preeclampsia Open
Insufficient immune tolerance during pregnancy is associated with pathological conditions such as preeclampsia (PE). Soluble fms-like tyrosine kinase-1 (sFLT1), which exerts a role in the late stage of PE, has shown its beneficial anti-inf…
View article: Endoglin Is an Important Mediator in the Final Common Pathway of Chronic Kidney Disease to End-Stage Renal Disease
Endoglin Is an Important Mediator in the Final Common Pathway of Chronic Kidney Disease to End-Stage Renal Disease Open
Chronic kidney disease (CKD) is a slow-developing, progressive deterioration of renal function. The final common pathway in the pathophysiology of CKD involves glomerular sclerosis, tubular atrophy and interstitial fibrosis. Transforming g…
View article: The VEGF Inhibitor Soluble Fms-like Tyrosine Kinase 1 Does Not Promote AKI-to-CKD Transition
The VEGF Inhibitor Soluble Fms-like Tyrosine Kinase 1 Does Not Promote AKI-to-CKD Transition Open
(1) Background: Soluble Fms-like tyrosine kinase 1 (sFLT1) is an endogenous VEGF inhibitor. sFLT1 has been described as an anti-inflammatory treatment for diabetic nephropathy and heart fibrosis. However, sFLT1 has also been related to per…
View article: Use of Glomerular CD68+ Cells as a Surrogate Marker for Endocapillary Hypercellularity in Lupus Nephritis
Use of Glomerular CD68+ Cells as a Surrogate Marker for Endocapillary Hypercellularity in Lupus Nephritis Open
In LN, CD68+ cells can be used as a surrogate marker for endocapillary hypercellularity.
View article: Endoglin Promotes Myofibroblast Differentiation and Extracellular Matrix Production in Diabetic Nephropathy
Endoglin Promotes Myofibroblast Differentiation and Extracellular Matrix Production in Diabetic Nephropathy Open
Diabetic nephropathy (DN) is a complication of diabetes mellitus that can lead to proteinuria and a progressive decline in renal function. Endoglin, a co-receptor of TGF-β, is known primarily for regulating endothelial cell function; howev…
View article: TMA: Tell Me About It!
TMA: Tell Me About It! Open
During a gathering of the United States & Canadian Academy of Pathology in March 2019, where we celebrated the publication of a new edition of a book on renal histology, a discussion about “TMA” arose. Surya V. Seshan of Weill Cornell Medi…
View article: Anti-plasminogen antibodies in ANCA-associated vasculitis: An optimized anti-plasminogen assay
Anti-plasminogen antibodies in ANCA-associated vasculitis: An optimized anti-plasminogen assay Open
Anti-plasminogen antibodies (α-PLG) were previously detected in a subpopulation of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients, showing a relation to renal lesions and outcome. Several studies showed di…
View article: Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort
Reproducibility of the Oxford classification of immunoglobulin A nephropathy, impact of biopsy scoring on treatment allocation and clinical relevance of disagreements: evidence from the VALidation of IGA study cohort Open
Background The VALidation of IGA (VALIGA) study investigated the utility of the Oxford Classification of immunoglobulin A nephropathy (IgAN) in 1147 patients from 13 European countries. Methods. Biopsies were scored by local pathologists f…
View article: Towards standardized criteria for diagnosing chronic intervillositis of unknown etiology: A systematic review
Towards standardized criteria for diagnosing chronic intervillositis of unknown etiology: A systematic review Open
Chronic intervillositis of unknown etiology (CIUE) is a poorly understood, relatively rare condition characterized histologically by the intervillous infiltration of mononuclear cells in the placenta. Clinically, CIUE is associated with po…
View article: Predicting Outcome in Patients with Anti-GBM Glomerulonephritis
Predicting Outcome in Patients with Anti-GBM Glomerulonephritis Open
Background and objectives Large studies on long-term kidney outcome in patients with anti-glomerular basement membrane (anti-GBM) GN are lacking. This study aimed to identify clinical and histopathologic parameters that predict kidney outc…
View article: WS9_1 International Validation Study for the Histopathological Classification of ANCA-Associated Glomerulonephritis (AAGN)
WS9_1 International Validation Study for the Histopathological Classification of ANCA-Associated Glomerulonephritis (AAGN) Open
Background: In the original validation study for the histopathological classification of AAGN, the order of classes from focal to sclerotic corresponded to increasing severity of renal function loss.Subsequent validation studies (N¼15) dis…
View article: Brain histopathology in patients with systemic lupus erythematosus: identification of lesions associated with clinical neuropsychiatric lupus syndromes and the role of complement
Brain histopathology in patients with systemic lupus erythematosus: identification of lesions associated with clinical neuropsychiatric lupus syndromes and the role of complement Open
Our study demonstrates that histopathological lesions in NPSLE represent a continuum, ranging from non-specific lesions such as focal vasculopathy, to more specific lesions including C4d- and C5b-9-associated microthrombi and diffuse vascu…