John R. Adler
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Global Growth and Distribution of CyberKnife Stereotactic Radiosurgery: A Bibliometric Analysis: Corrigendum Open
[This corrects the article DOI: 10.1227/neuprac.0000000000000150.].
Localized Nonablative Neuromodulatory Irradiation of the Nucleus Accumbens Ameliorates Voluntary Excessive Alcohol Consumption in Miniature Pigs Open
In a large-animal model, we indicated that low-dose, nonablative focal irradiation of the bilateral NAc can reduce chronic excessive voluntary alcohol consumption.
Nucleus Accumbens: A Therapeutic Target for Radiomodulation for the Treatment of Alcohol Use Disorder Open
Despite progress in pharmaceutical and behavioral treatments, alcohol use disorder (AUD) continues to have a high relapse rate. While deep brain stimulation (DBS) of the nucleus accumbens (NAc) has shown therapeutic promise, its invasive n…
Technical Assessment of the Targeting Accuracy of Stereotactic Frames Open
The precision and quality of a radiosurgical procedure depend on the ability to immobilize and position the patient's head. Often, this is accomplished by means of a mechanical headframe. The ability to accurately position the head and kee…
Experimental and Monte Carlo based dosimetric investigation of a novel 3 mm radiosurgery 3 MV beam using the microSilicon detector Open
Background The ZAP‐X system is a novel gyroscopic radiosurgical system based on a 3 MV linear accelerator and collimator cones with a diameter between 4 and 25 mm. Advances in imaging modalities to detect small and early‐stage pathologies …
Dosimetric Comparison of Dedicated Radiosurgery Platforms for the Treatment of Essential Tremor: Technical Report Open
Essential tremor (ET) is one of the most common adult movement disorders. As the worldwide population ages, the incidence and prevalence of ET is increasing. Although most cases can be managed conservatively, there is a subset of ET that i…
Accountable Safety for Rollups Open
Accountability, the ability to provably identify protocol violators, gained prominence as the main economic argument for the security of proof-of-stake (PoS) protocols. Rollups, the most popular scaling solution for blockchains, typically …
IL-1 SRS Without the Bunker: Introduction and Clinical Experience of ZAP-X Gyroscopic Radiosurgery Open
Each year more than two million patients worldwide are potential candidates for SRS, yet due to the significant costs and complexities of historical delivery systems, only 150,000 patients currently receive such treatment. Japan Shonin-cle…
Self-Shielding for the ZAP-X®: Revised Characterization and Evaluation Open
The ZAP-X® is a newly designed, self-contained, and first-of-its-kind self-shielded therapeutic radiation therapy device dedicated to brain and head and neck stereotactic radiosurgery (SRS). By using an S-band linear accelerator (linac) an…
Lichenoid Keratosis Skin Biopsy: A Case Report of Malignant Hospital Charges Open
Skin cancers are the most common malignancy and are especially common among light-skinned individuals in sun-exposed areas. While in many cases, a characteristic or classic appearance of the lesion is sufficient to make a definitive diagno…
Potential Clinical Significance of Overall Targeting Accuracy and Motion Management in the Treatment of Tumors That Move With Respiration: Lessons Learnt From a Quarter Century of Stereotactic Body Radiotherapy From Dose Response Models Open
Objective To determine the long-term normal tissue complication probability with stereotactic body radiation therapy (SBRT) treatments for targets that move with respiration and its relation with the type of respiratory motion management (…
An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention Open
Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideal…
The Zap-X Radiosurgical System in the Treatment of Intracranial Tumors: A Technical Case Report Open
BACKGROUND AND IMPORTANCE The Zap-X system (Zap Surgical Systems Inc, San Carlos, California) is a radically new surgical robot designed for brain and head and neck radiosurgery. It represents the first new dedicated brain stereotactic rad…
Radionecrosis and cellular changes in small volume stereotactic brain radiosurgery in a porcine model Open
Stereotactic radiosurgery (SRS) has proven an effective tool for the treatment of brain tumors, arteriovenous malformation, and functional conditions. However, radiation-induced therapeutic effect in viable cells in functional SRS is also …
A phase I/II trial of 5-fraction stereotactic radiosurgery with 5-mm margins with concurrent temozolomide in newly diagnosed glioblastoma: primary outcomes Open
Background We sought to determine the maximum tolerated dose (MTD) of 5-fraction stereotactic radiosurgery (SRS) with 5-mm margins delivered with concurrent temozolomide in newly diagnosed glioblastoma (GBM). Methods We enrolled adult pati…
Web-Based Business Opportunity Open
This research aims to see how the benefits will be generated by being a user in web-based opportunity (Youtube). This research used qualitative approache and descriptive method with analytical techniques as well as literature studies to ex…
Characterization of a Novel Revolving Radiation Collimator Open
[This corrects the article DOI: 10.7759/cureus.2146.].