Clare L. Fraser
YOU?
Author Swipe
View article: Structural and functional biomarkers of visual dysfunction in MOG antibody-positive optic neuritis: a scoping review
Structural and functional biomarkers of visual dysfunction in MOG antibody-positive optic neuritis: a scoping review Open
Current clinical assessments may underestimate visual dysfunction in MOG-IgG ON. Prospective, longitudinal multimodal evaluation should be a key focus for future research, to identify the most sensitive biomarkers to be incorporated into r…
View article: Understanding the phenotype of genetically associated electronegative ERG retinopathies: comparing the full-field ERG b:a ratio
Understanding the phenotype of genetically associated electronegative ERG retinopathies: comparing the full-field ERG b:a ratio Open
Purpose The electronegative electroretinogram (ERG) is a specific clinical finding usually indicating inner retinal dysfunction occurring post-phototransduction. X-linked retinoschisis (XLRS) and complete and incomplete congenital stationa…
View article: Longitudinal Visual Biomarkers in Dominant Optic Atrophy: A Systematic Review and Meta‐Analysis
Longitudinal Visual Biomarkers in Dominant Optic Atrophy: A Systematic Review and Meta‐Analysis Open
Background Dominant Optic Atrophy (DOA) causes slowly progressive visual decline usually beginning in childhood. As new therapies come to clinical trial, the choice of biomarkers to be used as clinical trial endpoints has become a critical…
View article: The Use Of Fundus Photography In The Emergency Room—A Review
The Use Of Fundus Photography In The Emergency Room—A Review Open
Purpose of Review The ocular fundus reveals a wealth of pathophysiological findings which should change patient management in the emergency room (ER). Traditional fundoscopy has been technically challenging and diagnostically inaccurate, b…
View article: Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors
Consensus disease definitions for ophthalmic immune-related adverse events of immune checkpoint inhibitors Open
Ophthalmic immune-related adverse events (Eye-irAEs) from immune checkpoint inhibitors can cause visual morbidity. The absence of standardized definitions for Eye-irAEs not only impedes the development of evidence-based treatments but also…
View article: Whole genome sequencing of 10 families with optic disc drusen
Whole genome sequencing of 10 families with optic disc drusen Open
We identified a list of candidate genes. Studies including larger ODD families are necessary to identify robust candidate genes.
View article: Non-invasive assessment of intracranial pressure through the eyes: current developments, limitations, and future directions
Non-invasive assessment of intracranial pressure through the eyes: current developments, limitations, and future directions Open
Detecting and monitoring elevated intracranial pressure (ICP) is crucial in managing various neurologic and neuro-ophthalmic conditions, where early detection is essential to prevent complications such as seizures and stroke. Although trad…
View article: A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber's hereditary optic neuropathy
A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: Successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber's hereditary optic neuropathy Open
Key Clinical Message We report on the successful use of chemotherapy for treatment of stage 2B testicular seminoma in a carrier of the Leber's hereditary optic neuropathy 11778 mitochondrial mutation. Neurotoxic chemotherapy may not prompt…
View article: SD-OCT Imaging of Macular Changes in Fabry Disease: A Case Report
SD-OCT Imaging of Macular Changes in Fabry Disease: A Case Report Open
Fabry disease (FD) is a rare, X-linked lysosomal storage disorder that can result in fatal end-stage renal disease, heart failure, and cerebro-occlusive events. Vague clinical symptoms and rarity often mean diagnosis and potential treatmen…
View article: Headache Attributed to Refractive Error: Improvement after Topography-Guided Photorefractive Keratectomy with Corneal Cross-Linking in Patients with Keratoconus
Headache Attributed to Refractive Error: Improvement after Topography-Guided Photorefractive Keratectomy with Corneal Cross-Linking in Patients with Keratoconus Open
Purpose: To investigate if topography-guided photorefractive keratectomy (TGPRK) alleviates headache, particularly headache attributed to refractive errors (HARE) in keratoconus. Methods: Patients diagnosed with keratoconus undergoing TGPR…
View article: A case for the use of chemotherapy in hereditary optic neuropathies: successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber’s Hereditary Optic Neuropathy
A case for the use of chemotherapy in hereditary optic neuropathies: successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber’s Hereditary Optic Neuropathy Open
A case for the use of chemotherapy in hereditary mitochondrial optic neuropathies: successful administration of cisplatin/etoposide in a male patient with testicular seminoma and Leber’s Hereditary Optic NeuropathyVrisakis J, Fraser C.L., …
View article: Globe trauma associated with falls at Australian tertiary centres
Globe trauma associated with falls at Australian tertiary centres Open
Objective Falls frequently cause globe and adnexal trauma, particularly in the elderly. The morbidity decreases confidence, independence and quality of life. We aimed to improve the understanding of fall‐related globe and adnexal trauma an…
View article: Burn related globe and adnexal trauma at trauma centres
Burn related globe and adnexal trauma at trauma centres Open
Chemicals in household-products can cause severe globe trauma. Globe trauma can occur alongside large burns leading to delay in its diagnosis and management. Ophthalmology can assist in the early diagnosis and management of globe trauma.
View article: Guidelines of the International Headache Society for Controlled Clinical Trials in Idiopathic Intracranial Hypertension
Guidelines of the International Headache Society for Controlled Clinical Trials in Idiopathic Intracranial Hypertension Open
The quality of clinical trials is essential to advance treatment, inform regulatory decisions and meta-analysis. With the increased incidence of idiopathic intracranial hypertension and the emergence of clinical trials for novel therapies …
View article: A Deep Learning Approach to Accurately Discriminate Between Optic Disc Drusen and Papilledema on Fundus Photographs
A Deep Learning Approach to Accurately Discriminate Between Optic Disc Drusen and Papilledema on Fundus Photographs Open
Objective To assess the performance of a deep learning system (DLS) to discriminate between optic disc drusen (ODD) and papilledema caused by intracranial hypertension, using standard color ocular fundus photographs collected in a large in…
View article: Opinion article: Neurosurgical treatment for neuro-ophthalmologic conditions
Opinion article: Neurosurgical treatment for neuro-ophthalmologic conditions Open
A significant role of the neuro-ophthalmologist is to counsel patients on appropriate management and anticipated visual prognosis for conditions affecting the afferent and efferent visual systems, including those requiring neurosurgical tr…
View article: Editorial: Neurosurgical treatment for neuro-ophthalmologic conditions: Intracranial pressure disorders
Editorial: Neurosurgical treatment for neuro-ophthalmologic conditions: Intracranial pressure disorders Open
EDITORIAL article Front. Ophthalmol., 12 October 2022Sec. Neuro-Ophthalmology Disorders Volume 2 - 2022 | https://doi.org/10.3389/fopht.2022.1021667
View article: 2429 Investigating traumatic encephalopathy syndrome (TES) in retired athletes, military personnel and victims of assault with a history of sustained, repetitive mild traumatic brain injury
2429 Investigating traumatic encephalopathy syndrome (TES) in retired athletes, military personnel and victims of assault with a history of sustained, repetitive mild traumatic brain injury Open
Objectives The SNAP-CTE Study aims to identify features and characteristics of the in-life experience of those who may be suffering from Chronic Traumatic Encephalopathy (CTE) and correlated Traumatic Encephalopathy Syndrome (TES). A cohor…
View article: 2383 Does surgical correction of refractive error alleviate headache in patients with keratoconus? – A retrospective analysis
2383 Does surgical correction of refractive error alleviate headache in patients with keratoconus? – A retrospective analysis Open
Objectives Refractive error has long been thought to be a cause for headache, however, historical research on this topic has major methodical limitations. Often, patients with different headache types were examined together, making any dir…
View article: Issue Information
Issue Information Open
of ethics, and engaging our colleagues and other stakeholders in our efforts.
View article: Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device
Electrophysiological Assessment in Birdshot Chorioretinopathy: Flicker Electroretinograms Recorded With a Handheld Device Open
Flicker ERGs, known to be useful in BCR, can be obtained rapidly with a portable device with skin electrodes and natural pupils.