Jie Li
YOU?
Author Swipe
View article: Advances in clinical application on nursing intervention for ribavirin-associated adverse events
Advances in clinical application on nursing intervention for ribavirin-associated adverse events Open
Ribavirin is a broad-spectrum antiviral drug used to treat chronic hepatitis C, respiratory syncytial virus infections, and other viral diseases. However, its clinical use is often limited by adverse events, including hemolytic anemia, gas…
View article: Lower insulin resistance in Chinese patients with severe major depressive disorder: associations with the inflammatory response
Lower insulin resistance in Chinese patients with severe major depressive disorder: associations with the inflammatory response Open
Background Major depressive disorder (MDD) is widely acknowledged as stemming from the dysregulation of neuroimmune, metabolic, and oxidative stress (NIMETOX) pathways. The objective of this study was to examine insulin metabolism in Chine…
View article: Lacticaseibacillus rhamnosus LGG Suppresses Osteoclastogenesis via TLR6/NF-κB Modulation and Attenuates Ovariectomy-Induced Bone Loss in Mice
Lacticaseibacillus rhamnosus LGG Suppresses Osteoclastogenesis via TLR6/NF-κB Modulation and Attenuates Ovariectomy-Induced Bone Loss in Mice Open
Osteoporosis is characterized by decreased bone mass and disrupted microarchitecture. Gut microbiota-derived factors may regulate bone homeostasis. This study investigated the effects and mechanisms of Lacticaseibacillus rhamnosus LGG, con…
View article: Differential metabolic responses of mouse Leydig and spermatogonia cells to radiofrequency electromagnetic field exposure
Differential metabolic responses of mouse Leydig and spermatogonia cells to radiofrequency electromagnetic field exposure Open
Introduction Although existing studies have shown that radiofrequency electromagnetic fields (RF-EMFs) have a variety of effects on living organisms, the specific impact of RF-EMFs on the metabolism of reproductive cells and their underlyi…
View article: BrainPath: A Biologically-Informed AI Framework for Individualized Aging Brain Generation
BrainPath: A Biologically-Informed AI Framework for Individualized Aging Brain Generation Open
The global population is aging rapidly, and aging is a major risk factor for various diseases. It is an important task to predict how each individual's brain will age, as the brain supports many human functions. This capability can greatly…
View article: Efficacy of Pola-R-CHP and Autologous Stem Cell Transplantation in Untreated Burkitt Lymphoma: A Case Report
Efficacy of Pola-R-CHP and Autologous Stem Cell Transplantation in Untreated Burkitt Lymphoma: A Case Report Open
BACKGROUND Burkitt lymphoma is an aggressive B-cell lymphoma curable with highly dose-intensive chemotherapy derived from pediatric leukemia regimens. However, the adverse event profile, including myelosuppression, infection, and multi-org…
View article: Transcription Factor <scp>TCF12</scp>‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation
Transcription Factor <span>TCF12</span>‐Mediated Maternal Gene Expressions in Mouse Oocyte Are Prerequisites of Successful Fertilisation and Zygotic Genome Activation Open
The maternal gene products stored in oocytes control the initial development of multicellular animals. Alteration within the dual allelic variants of transcription factor TCF12 causes female infertility; however, its impact on female repro…
View article: Thyroid peroxidase antibodies do not impair the ovarian reserve in euthyroid women: a cross-sectional study
Thyroid peroxidase antibodies do not impair the ovarian reserve in euthyroid women: a cross-sectional study Open
Aim This study aims to investigate whether thyroid peroxidase antibodies (TPOAb) affect the ovarian reserve using the anti-Müllerian hormone (AMH), basal follicle-stimulating hormone (bFSH), and estradiol (bE2) as markers. Methods A large …
View article: Ufmylation Suppresses Unfolded Protein Response to Prevent Peripartum Cardiomyopathy
Ufmylation Suppresses Unfolded Protein Response to Prevent Peripartum Cardiomyopathy Open
Ufmylation is a novel ubiquitin-like protein modification that plays a critical role in maintaining the homeostasis of different tissues, but its role in the heart remains poorly understood. Here, we showed that mice lacking UFM1 ligase 1 …
View article: Single-cell transcriptomics identify a chemotherapy-resistance related cluster overexpressed CLIC3 in ovarian cancer
Single-cell transcriptomics identify a chemotherapy-resistance related cluster overexpressed CLIC3 in ovarian cancer Open
This study offers a novel insight into the progression and chemoresistance of OC. Additionally, we identified a specific cell cluster highly associated with chemoresistance. The marker for this cluster, CLIC3, increases OC resistance to ci…
View article: LaF-GRPO: In-Situ Navigation Instruction Generation for the Visually Impaired via GRPO with LLM-as-Follower Reward
LaF-GRPO: In-Situ Navigation Instruction Generation for the Visually Impaired via GRPO with LLM-as-Follower Reward Open
Navigation instruction generation for visually impaired (VI) individuals (NIG-VI) is critical yet relatively underexplored. This study focuses on generating precise, in-situ, step-by-step navigation instructions that are practically usable…
View article: Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution
Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolution Open
The intestinal epithelium is often a site of pathology, such as in inflammatory bowel disease (IBD), and its maintenance is highly modulated by interactions with the microenvironment. However, a systematic understanding of how the myriad o…
View article: The evaluation and molecular mechanisms of hepatotoxicity induced by trans-emodin dianthrones isolated from Polygonum multiflorum Thunb. in vitro
The evaluation and molecular mechanisms of hepatotoxicity induced by trans-emodin dianthrones isolated from Polygonum multiflorum Thunb. in vitro Open
Trans-emodin dianthrones exhibited significant hepatotoxicity at the level of HepG2 cells, and its mechanism is related to inhibiting the antioxidant system, causing mitochondrial dysfunction and inducing apoptosis induced by JNK/Bax and P…
View article: The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease
The Active Components of Traditional Chinese Medicines Regulate the Multi-Target Signaling Pathways of Metabolic Dysfunction-Associated Fatty Liver Disease Open
Metabolic dysfunction-associated fatty liver disease (MAFLD), which is characterized by hepatocyte lipid accumulation driven by systemic metabolic dysregulation, represents a critical therapeutic challenge in the context of the global meta…
View article: Divalent cations govern the activity of coronavirus nsp15
Divalent cations govern the activity of coronavirus nsp15 Open
SUMMARY Coronavirus nsp15 is an endoribonuclease that limits the accumulation of viral dsRNA in cytosol and plays a crucial role in the evasion of host immunity. Here, we show that Co 2+ or Ni 2+ potently activates nsp15 of human and anima…
View article: 3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis
3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis Open
Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor. In lung cancer, AHR activation stimulates cancer cell proliferation and promotes tissue invasion and metastasis, and targeting the AHR pathway is an effective way …
View article: Untargeted metabolomics reveals homogeneity and heterogeneity between physiological and pathological ovarian aging
Untargeted metabolomics reveals homogeneity and heterogeneity between physiological and pathological ovarian aging Open
Not applicable.
View article: Seminal plasma exosome derived miR-26-5p can regulate decidual macrophage polarization via PTEN / PI3K / AKT signaling pathway
Seminal plasma exosome derived miR-26-5p can regulate decidual macrophage polarization via PTEN / PI3K / AKT signaling pathway Open
The immunomodulatory effects of seminal plasma (SP) on the maternal immune system play an important role in the implantation and development of the embryo. Decidual macrophages (dMΦs) are one of the major immune cells in the maternal-fetal…
View article: Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes
Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes Open
Up‐regulation of Centrosomal Protein 55 (CEP55) in cancer cells increases malignancy, and the protein can be transferred via exosomes. However, the mechanism of how CEP55 is delivered to exosomes is unknown. In this study, we addressed thi…
View article: An Insect Effector Mimics Its Host Immune Regulator to Undermine Plant Immunity
An Insect Effector Mimics Its Host Immune Regulator to Undermine Plant Immunity Open
Plants activate defense machinery when infested by herbivorous insects but avoid such costs in the absence of herbivory. However, the key signaling pathway regulators underlying such flexibility and the mechanisms that insects exploit thes…
View article: GenX induces offspring vascular endothelial ferroptosis by targeting GPX4 for ubiquitination-dependent degradation
GenX induces offspring vascular endothelial ferroptosis by targeting GPX4 for ubiquitination-dependent degradation Open
GenX, a widely used replacement for PFOA, has become ubiquitously distributed in aquatic ecosystems, soil, and biota, yet its developmental toxicity in offspring is poorly characterized. This study delineates the intergenerational vascular…
View article: Cardiovascular health, genetic predisposition, and dementia risk among atherosclerotic cardiovascular disease patients
Cardiovascular health, genetic predisposition, and dementia risk among atherosclerotic cardiovascular disease patients Open
Higher CVH levels were associated with a lower risk of VaD, not AD, with a stronger association in individuals with low GRS. Improvements in specific LE8 components, particularly sleep health and blood glucose management, were associated w…