Jean‐François Bach
YOU?
Author Swipe
View article: Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice
Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice Open
Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many wi…
View article: De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes
De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes Open
Significance The vast majority of autoimmune diseases are polygenic, and causal loci uncovered by genetic-mapping studies explain only a minority of the heritable contribution to trait variation. Multiple explanations for this missing heri…
View article: COVID-19: individual and herd immunity
COVID-19: individual and herd immunity Open
Immunity to the SARS-CoV-2 virus ensures protection against reinfection by this virus thanks to the combined action of neutralizing antibodies and T lymphocytes specific to viral proteins, in particular the Spike protein. It must be distin…
View article: Revisiting the Hygiene Hypothesis in the Context of Autoimmunity
Revisiting the Hygiene Hypothesis in the Context of Autoimmunity Open
Initially described for allergic diseases, the hygiene hypothesis was extended to autoimmune diseases in the early 2000s. A historical overview allows appreciation of the development of this concept over the last two decades and its discus…
View article: <i>De novo</i>germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice
<i>De novo</i>germline mutation in the Dual Specificity Phosphatase 10 gene accelerates autoimmune diabetes in Non-Obese Diabetic (NOD) mice Open
Here we report the isolation by selective breeding of two sublines of Non-Obese Diabetic (NOD) mice exhibiting a significant difference in the incidence of autoimmune type 1 diabetes (T1D). Whole genome sequencing of the NOD/Nck H (high T1…
View article: EXECUTIVE SUMMARY
EXECUTIVE SUMMARY Open
Importance of data from spaceData from outer space is increasingly important to scientific fields, including the humanities and social sciences and the life sciences, in particular biology.Most activities in the Earth sciences are coupled …
View article: Perspective Summary of Brief Report on Thyroid Disease of Post Glaciations Quaternary Is Endocrinology of Ecology System in Centre Marc Sankale Setting in Dakar
Perspective Summary of Brief Report on Thyroid Disease of Post Glaciations Quaternary Is Endocrinology of Ecology System in Centre Marc Sankale Setting in Dakar Open
Reflexions about immunoradiometric Tsh and Trh test during on Optimal thyroid hormonal therapy (Optimal dosages and overdosages) as Pionnary Auto-immune Primary Hypothyroidism in Dakar [Senegal] gives us A Propose of Whitaker Syndrome Case…
View article: Markers of microbial exposure lower the incidence of atopic dermatitis
Markers of microbial exposure lower the incidence of atopic dermatitis Open
Background The hygiene hypothesis proposes that reduced exposure to infectious agents in early life would explain the increase of allergic and autoimmune diseases observed over the past decades in high‐income countries. Methods We conducte…
View article: Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study
Adjuvant treatment with the bacterial lysate (OM-85) improves management of atopic dermatitis: A randomized study Open
Results show an adjuvant therapeutic effect of a well standardized bacterial lysate OM-85 on established AD.
View article: Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes
Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Insulin-Dependent Diabetes Open
Insulin-dependent or type 1 diabetes is a prototypic autoimmune disease whose incidence steadily increased over the past decades in industrialized countries. Recent evidence suggests the importance of the gut microbiota to explain this tre…