Peter J. Barnes
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View article: SAT-728 Bone Mineral Density Challenges In Pediatric And Young Adults With Eosinophilic Esophagitis: A Closer Look At Risks And Insights.
SAT-728 Bone Mineral Density Challenges In Pediatric And Young Adults With Eosinophilic Esophagitis: A Closer Look At Risks And Insights. Open
Disclosure: S.S. Chugh: None. U.A. Khawaja: None. B.H. Barnes: Sanofi, Regeneron Pharmaceuticals. E.C. McGowan: Takeda, Bristol-Myers Squibb, AstraZeneca, Regeneron Pharmaceuticals, Sanofi. M. Misra: None. Background: Eosinophilic esophagi…
View article: The Three-mm Ultimate Mopra Milky Way Survey. III. Data Release 6, An Atlas of Physical Conditions, Global Mass Conversion Laws, and 3D Physical Architecture of the Molecular Interstellar Medium in the Fourth Quadrant
The Three-mm Ultimate Mopra Milky Way Survey. III. Data Release 6, An Atlas of Physical Conditions, Global Mass Conversion Laws, and 3D Physical Architecture of the Molecular Interstellar Medium in the Fourth Quadrant Open
We present Data Release 6 of ThrUMMS, consisting of complete data cubes and various moments of line emission ( 12 CO, 13 CO, C 18 O) from molecular clouds, across 60° × 2° of the Fourth Quadrant (4Q) of the Milky Way at a resolution of 72″…
View article: The Magnetic Keys to Massive Star Formation: The Western <i>η</i> Carinae Giant Molecular Cloud
The Magnetic Keys to Massive Star Formation: The Western <i>η</i> Carinae Giant Molecular Cloud Open
We present SOFIA/HAWC+ continuum polarization data on the magnetic fields ( B fields) threading 17 pc-scale massive molecular clumps at the western end of the η Carinae giant molecular cloud (Region 9 of the Galactic Census of High- and Me…
View article: Naldemedine Use and Healthcare Resource Utilization in Patients treated with Opioid Analgesics for Chronic Non-Cancer Pain: Results of a Real-world Study in the USA
Naldemedine Use and Healthcare Resource Utilization in Patients treated with Opioid Analgesics for Chronic Non-Cancer Pain: Results of a Real-world Study in the USA Open
This real-world study demonstrates that naldemedine is predominantly used in middle-aged adults with comorbidities and polypharmacy. Naldemedine use was associated with reduced HCRU, particularly in older adults, suggesting potential benef…
View article: Contribution of Peripheral Airways Dysfunction to Poor Quality of Life in Sarcoidosis
Contribution of Peripheral Airways Dysfunction to Poor Quality of Life in Sarcoidosis Open
Our results indicate that oscillometric lung function parameters, especially those of peripheral airway dysfunction, are correlated more strongly to a QoL measure than spirometry in patients with sarcoidosis.
View article: Pocket guide: biologics in upper and lower airways in adults
Pocket guide: biologics in upper and lower airways in adults Open
The introduction of biologics for the treatment of severe upper and lower (type 2) airway inflammation has been a gamechanger in the management of these diseases. Biologics are injectable medications targeting different molecules relevant …
View article: Chronic Obstructive Pulmonary Disease Airway Epithelial Cell–derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a
Chronic Obstructive Pulmonary Disease Airway Epithelial Cell–derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a Open
Chronic obstructive pulmonary disease (COPD) is associated with the acceleration of lung aging and the accumulation of senescent cells in lung tissue. MicroRNA-34a (miR-34a) induces senescence by suppressing the antiaging molecule sirtuin-…
View article: Review of hemodynamics in direct aspiration thrombectomy for the treatment of acute ischemic stroke
Review of hemodynamics in direct aspiration thrombectomy for the treatment of acute ischemic stroke Open
Introduction: Acute ischemic stroke (AIS) is a common and lethal cerebral vascular disease. Early thrombus removal is crucial to the patient treatment and recovery. Clinical studies suggested that Direct Aspiration Thrombectomy (DAT) is a …
View article: Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics
Radiomultiomics: quantitative CT clusters of severe asthma associated with multiomics Open
Background Lung quantitative computed tomography (qCT) severe asthma clusters have been reported, but their replication and underlying disease mechanisms are unknown. We identified and replicated qCT clusters of severe asthma in two indepe…
View article: Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement
Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement Open
Background Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased healthspan. With advancing age, the increased prevalence of ageing-related diseases can have a significant…
View article: Paradoxical eosinophilic and cytokine responses to oral corticosteroid treatment in patients with asthma exacerbations
Paradoxical eosinophilic and cytokine responses to oral corticosteroid treatment in patients with asthma exacerbations Open
In some asthmatic patients with acute exacerbations who do not suppress eosinophils after a course of OCS, there is a paradoxical decrease in plasma miR-1 level and increase in TSLP level versus in steroid responders, which may result in s…
View article: Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19
Coordinated nasal mucosa-mediated immunity accelerates recovery from COVID-19 Open
Introduction Understanding the interplay of immune mediators in relation to clinical outcomes during acute infection has the potential to highlight immune networks critical to symptom recovery. The objective of the present study was to elu…
View article: Small airway fibroblasts from patients with chronic obstructive pulmonary disease exhibit cellular senescence
Small airway fibroblasts from patients with chronic obstructive pulmonary disease exhibit cellular senescence Open
Fibroblasts and senescence are thought to play key roles in the pathogenesis of small airway disease and COPD; however, the characteristics of small airway-derived fibroblasts are not well explored. In this study we isolate and enrich the …
View article: Extracellular vesicles propagate aging in COPD airway epithelial cells by transfer of microRNA-34a
Extracellular vesicles propagate aging in COPD airway epithelial cells by transfer of microRNA-34a Open
Rationale Chronic obstructive pulmonary disease (COPD) is associated with the acceleration of lung aging, demonstrated by the accumulation of senescent cells in lung tissue. MicroRNA (miR)-34a is induces senescence by suppressing the key a…
View article: Rational use of inhaled corticosteroids for the treatment of COPD: a plain language summary
Rational use of inhaled corticosteroids for the treatment of COPD: a plain language summary Open
What is this summary about? Inhaled corticosteroids (ICS) are a type of medication delivered via an inhaler device that are commonly used in the treatment of asthma. ICS can also be used to treat chronic obstructive pulmonary disease (COPD…
View article: T2 A novel drug target: IL-36 signalling drives inflammation and poor bacterial clearance in COPD
T2 A novel drug target: IL-36 signalling drives inflammation and poor bacterial clearance in COPD Open
The inflammatory cytokine IL-36γ is increased in COPD lungs, whereas its endogenous inhibitor IL-36 receptor antagonist (IL-36RA) is reduced. IL-36 receptor signalling drives neutrophilic inflammation. Macrophages are critical in modulati…
View article: S28 Non-invasive nasal sampling using nasosorption may identify COPD inflammatory profiles and have a role as a diagnostic tool in exacerbations
S28 Non-invasive nasal sampling using nasosorption may identify COPD inflammatory profiles and have a role as a diagnostic tool in exacerbations Open
COPD is a heterogenous disease and there is ongoing need to identify biomarkers for treatable endotypes. Nasosorption is a non-invasive and safe way of sampling the respiratory tract to obtain undiluted endothelial lining fluid. This stud…
View article: P208 Extracellular vesicles from COPD small airway fibroblasts spread senescence to healthy fibroblasts
P208 Extracellular vesicles from COPD small airway fibroblasts spread senescence to healthy fibroblasts Open
Background COPD is associated with cellular senescence and fibrosis. Extracellular vesicles (EVs) are membrane-derived vesicles involved in intercellular communication. EVs contain miRNAs, mRNA and proteins and have been implicated in COPD…
View article: <scp>DEL</scp>‐1, as an anti‐neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma
<span>DEL</span>‐1, as an anti‐neutrophil transepithelial migration molecule, inhibits airway neutrophilic inflammation in asthma Open
Background Neutrophil migration into the airways is a key process in neutrophilic asthma. Developmental endothelial locus‐1 (DEL‐1), an extracellular matrix protein, is a neutrophil adhesion inhibitor that attenuates neutrophilic inflammat…
View article: Expression profiling identifies key genes and biological functions associated with eosinophilic esophagitis in human patients
Expression profiling identifies key genes and biological functions associated with eosinophilic esophagitis in human patients Open
Introduction Eosinophilic Esophagitis (EoE) is a chronic allergic disease characterized by progressive inflammation of the esophageal mucosa. This chronic inflammatory disorder affects up to 50 per 100,000 individuals in the United States …
View article: Gold 2023: Highlights for primary care
Gold 2023: Highlights for primary care Open
ON BEHALF OF THE MEMBERS OF THE SCIENTIFIC COMMITTEE OF GOLD (APPENDIX) Antonio Anzueto, Peter Barnes, Jean Bourbeau , Bartolome R. Celli, Gerard J. Criner, David Halpin, MeiLan K. Han, Fernando J. Martinez, Maria Montes de Oca, Kevin Mort…