Bruce J. Baum
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View article: The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020
The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020 Open
The clinical burden caused by influenza can be mitigated by the prophylactic use of seasonal influenza vaccines. Their immunogen composition is revised biannually to optimally match the antigenic drift of the hemagglutinin of circulating i…
View article: The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020
The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020 Open
The clinical burden caused by influenza can be mitigated by the prophylactic use of seasonal influenza vaccines. Their immunogen composition is revised biannually to optimally match the antigenic drift of the hemagglutinin of circulating i…
View article: The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020
The antigenic landscape of N1 neuraminidase in human influenza A virus strains isolated between 2009 and 2020 Open
The clinical burden caused by influenza can be mitigated by the prophylactic use of seasonal influenza vaccines. Their immunogen composition is revised biannually to optimally match the antigenic drift of the hemagglutinin of circulating i…
View article: Data from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation
Data from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation Open
Head and neck cancer patients treated by radiation commonly suffer from a devastating side effect known as dry-mouth syndrome, which results from the irreversible loss of salivary gland function via mechanisms that are not completely under…
View article: Data from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation
Data from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation Open
Head and neck cancer patients treated by radiation commonly suffer from a devastating side effect known as dry-mouth syndrome, which results from the irreversible loss of salivary gland function via mechanisms that are not completely under…
View article: Supplementary Table 1, Supplementary Figures 1 through 9, and Supplementary Materials and Methods from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation
Supplementary Table 1, Supplementary Figures 1 through 9, and Supplementary Materials and Methods from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation Open
Supplementary Table S1 - Patient Characteristics Supplementary Fig. S1 - IR-induced morphology and inflammatory responses Supplementary Fig. S2 - Apoptosis following IR Supplementary Fig. S3 - Morphology, Aquaporin and ??H2AX in Acini foll…
View article: Supplementary Table 1, Supplementary Figures 1 through 9, and Supplementary Materials and Methods from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation
Supplementary Table 1, Supplementary Figures 1 through 9, and Supplementary Materials and Methods from Radiation-Induced Loss of Salivary Gland Function Is Driven by Cellular Senescence and Prevented by IL6 Modulation Open
Supplementary Table S1 - Patient Characteristics Supplementary Fig. S1 - IR-induced morphology and inflammatory responses Supplementary Fig. S2 - Apoptosis following IR Supplementary Fig. S3 - Morphology, Aquaporin and ??H2AX in Acini foll…
View article: APSA Contributors
APSA Contributors Open
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View article: Advances in salivary gland gene therapy – oral and systemic implications
Advances in salivary gland gene therapy – oral and systemic implications Open
Salivary gland gene transfer is safe and can be beneficial in humans. Applications to treat and prevent radiation damage show considerable promise. A first-in-human clinical trial for the former was recently successfully completed. Studies…
View article: 325. Persistence of hAQP1 Expression in Human Salivary Gland Cells Following AdhAQP1 Transduction Is Associated With a Lack of Methylation of hCMV Promoter
325. Persistence of hAQP1 Expression in Human Salivary Gland Cells Following AdhAQP1 Transduction Is Associated With a Lack of Methylation of hCMV Promoter Open
In 2012, we reported that five out of 11 subjects in a clinical trial (NCT00372320) of AdhAQP1 to radiation-damaged parotid glands showed increased saliva flow rates and decreased symptoms over the initial 42 days. AdhAQP1 is a first gener…