Brian J. Nieman
YOU?
Author Swipe
View article: Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice
Vincristine-induced brain toxicity is reduced with prevention of peripheral axon degeneration in Sarm1 knockout mice Open
Vincristine is an essential chemotherapy agent administered for various pediatric cancers including acute lymphoblastic leukemia (ALL). While multi-agent chemotherapy for pediatric ALL is highly curative, with survival approaching 95%, it …
View article: LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2
LncRNA CISTR-ACT regulates cell size in human and mouse by guiding FOSL2 Open
Organisms regulate cell size and shape to function efficiently. Aberrant cell morphogenesis is commonly associated with disease, yet gene-regulatory mechanisms remain unknown. CISTR-ACT was the first lncRNA involved in inter-chromosomal pr…
View article: Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study
Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study Open
Maternal diet and metabolic conditions, such as obesity and diabetes, are associated with consequences for offspring brain health, including effects on behaviour and an increased risk for neurodevelopmental disorders (NDDs). The extent and…
View article: Enrichment-induced forgetting is associated with white matter microstructure in mice
Enrichment-induced forgetting is associated with white matter microstructure in mice Open
Memories are stored in brain circuits, sometimes referred to as engrams. Forgetting happens when these neural activity patterns fail to be reactivated by retrieval cues. Neuroplasticity can destabilize existing memory circuits by altering …
View article: Oligodendrogenesis Inhibition in the Juvenile and Adolescent Periods Differentially Alters Myelin in Mice
Oligodendrogenesis Inhibition in the Juvenile and Adolescent Periods Differentially Alters Myelin in Mice Open
Introduction: The timing of myelination during development varies spatially according to the evolving functional demands of the maturing brain and is likely a mechanism of plasticity that contributes to sensitive periods of brain developme…
View article: Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders
Assigning Targetable Molecular Pathways to Transdiagnostic Subgroups Across Autism and Related Neurodevelopmental Disorders Open
Significant genetic, behavioural and neuroanatomic heterogeneity is common in autism spectrum- and related- neurodevelopmental disorders (NDDs). This heterogeneity constrains the development of effective therapies for diverse patients in p…
View article: Minimally invasive measurement of carotid artery and brain temperature in the mouse
Minimally invasive measurement of carotid artery and brain temperature in the mouse Open
Purpose Brain temperature is tightly regulated and reflects a balance between cerebral metabolic heat production and heat transfer between the brain, blood, and external environment. Blood temperature and flow are critical to the regulatio…
View article: Post‐mortem MR imaging of tau pathology – a pilot study
Post‐mortem MR imaging of tau pathology – a pilot study Open
Background In‐vivo detection of neuropathology is critical for early diagnosis of neurodegenerative diseases. Post‐mortem brain magnetic resonance imaging (MRI) of pathological protein inclusions could further our ability to detect them in…
View article: Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study
Impact of prenatal delta-9-tetrahydrocannabinol exposure on mouse brain development: a fetal-to-adulthood magnetic resonance imaging study Open
While cannabis use during pregnancy is often perceived as harmless, little is known about its consequences on offspring neurodevelopment. There is an urgent need to map the effects of prenatal cannabis exposure on the brain through the cou…
View article: Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation
Sex chromosomes and hormones independently influence healthy brain development but act similarly after cranial radiation Open
The course of normal development and response to pathology are strongly influenced by biological sex. For instance, female childhood cancer survivors who have undergone cranial radiation therapy (CRT) tend to display more pronounced cognit…
View article: Brain volume and microglial density changes are correlated in a juvenile mouse model of cranial radiation and CSF1R inhibitor treatment
Brain volume and microglial density changes are correlated in a juvenile mouse model of cranial radiation and CSF1R inhibitor treatment Open
Microglia have been shown to proliferate and become activated following cranial radiotherapy (CRT), resulting in a chronic inflammatory response. We investigated the role of microglia in contributing to widespread volume losses observed in…
View article: <i>Tmod2</i>is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticity
<i>Tmod2</i>is a regulator of cocaine responses through control of striatal and cortical excitability, and drug-induced plasticity Open
Drugs of abuse induce neuroadaptations, including synaptic plasticity, that are critical for transition to addiction, and genes and pathways that regulate these neuroadaptations are potential therapeutic targets. Tropomodulin 2 ( Tmod2 ) i…
View article: TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43
TDP-43-M323K causes abnormal brain development and progressive cognitive and motor deficits associated with mislocalised and increased levels of TDP-43 Open
TDP-43 pathology is found in several neurodegenerative disorders, collectively referred to as “TDP-43 proteinopathies”. Aggregates of TDP-43 are present in the brains and spinal cords of >97% of amyotrophic lateral sclerosis (ALS), and in …
View article: Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations
Mutation in the FUS nuclear localisation signal domain causes neurodevelopmental and systemic metabolic alterations Open
Variants in the ubiquitously expressed DNA/RNA-binding protein FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS). Most FUS mutation studies have focused on motor neuron degeneration; little is known about wider sys…
View article: Exercise promotes growth and rescues volume deficits in the hippocampus after cranial radiation in young mice
Exercise promotes growth and rescues volume deficits in the hippocampus after cranial radiation in young mice Open
Human and animal studies suggest that exercise promotes healthy brain development and function, including promoting hippocampal growth. Childhood cancer survivors that have received cranial radiotherapy exhibit hippocampal volume deficits …
View article: G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex
G9a inactivation in progenitor cells with Isl1-Cre with reduced recombinase activity models aspects of Dandy-Walker complex Open
G9a, also known as EHMT2, is essential for embryogenesis and has specific functions in multiple developmental processes. G9a inactivation affects development of the nervous system, which is formed with contribution of descendants of progen…
View article: A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects
A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects Open
ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but its role in neurological functio…
View article: Supplementary Information from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment
Supplementary Information from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment Open
Additional figures and tables
View article: Data from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment
Data from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment Open
Purpose:Chemotherapy for childhood acute lymphoblastic leukemia (ALL) can cause late-appearing side effects in survivors that affect multiple organs, including the heart and brain. However, the complex ALL treatment regimen makes it diffic…
View article: Data from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment
Data from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment Open
Purpose:Chemotherapy for childhood acute lymphoblastic leukemia (ALL) can cause late-appearing side effects in survivors that affect multiple organs, including the heart and brain. However, the complex ALL treatment regimen makes it diffic…
View article: Supplementary Information from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment
Supplementary Information from Brain Development and Heart Function after Systemic Single-Agent Chemotherapy in a Mouse Model of Childhood Leukemia Treatment Open
Additional figures and tables
View article: FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations
FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterations Open
FUS (Fused in sarcoma) is a ubiquitously expressed DNA/RNA binding protein. Mutations in FUS cause aggressive juvenile forms of amyotrophic lateral sclerosis (ALS), as in the case with the FUSDelta14 mutation. While most studies have focus…
View article: A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects
A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects Open
ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but its role in neurological functio…