Michael J. Blaha
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View article: The Role of Inflammation in Longitudinal Renal Function Decline and Incident Chronic Kidney Disease: The Multi-Ethnic Study of Atherosclerosis
The Role of Inflammation in Longitudinal Renal Function Decline and Incident Chronic Kidney Disease: The Multi-Ethnic Study of Atherosclerosis Open
Aims Chronic inflammation has been implicated in renal decline, but long-term population-based data are limited. We aimed to evaluate the associations between baseline inflammatory markers (interleukin-6 [IL-6] and high-sensitivity C-react…
View article: Racial Differences in Recurrent Acute Myocardial Infarction: Findings From the ARIC Cohort
Racial Differences in Recurrent Acute Myocardial Infarction: Findings From the ARIC Cohort Open
Background We examined racial differences in recurrent nonfatal acute myocardial infarction (AMI) and fatal coronary heart disease (CHD) among ARIC (Atherosclerosis Risk in Communities) cohort participants who survived a first AMI (1987–20…
View article: A Novel Longitudinal Proteomic Aging Index Predicts Mortality, Multimorbidity, and Frailty in Older Adults
A Novel Longitudinal Proteomic Aging Index Predicts Mortality, Multimorbidity, and Frailty in Older Adults Open
Previous studies have developed proteomic aging clocks to estimate biological age and predict mortality and age‐related diseases. However, these earlier clocks were based on cross‐sectional data, capturing only the cumulative aging burden …
View article: Proteome-wide association study of prostate cancer risk across populations
Proteome-wide association study of prostate cancer risk across populations Open
There is insufficient understanding of the molecular basis of prostate cancer (PCa) across different populations. We perform a large-scale proteome-wide association study (PWAS) to identify proteins with genetically regulated expression in…
View article: Association of ankle-brachial Index with coronary and extra-coronary calcification in older adults: ARIC study
Association of ankle-brachial Index with coronary and extra-coronary calcification in older adults: ARIC study Open
Aims To investigate potentially distinct associations of ankle brachial index (ABI), a marker of subclinical atherosclerosis, with calcification in different vascular beds and cardiac valves. Methods and results We studied 1420 ARIC partic…
View article: Finerenone Prescriptions in the US (2021-2024) by Physician Specialty: Analysis of Use and Potential in the CKM Space
Finerenone Prescriptions in the US (2021-2024) by Physician Specialty: Analysis of Use and Potential in the CKM Space Open
Introduction Finerenone, a non-steroidal mineralocorticoid receptor antagonist (MRA), has demonstrated greater receptor selectivity and fewer side effects compared to older mineralocorticoid receptor antagonists. Clinical trials support it…
View article: The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study
The Metabolic Vulnerability Index (MVX) in Subclinical Thyroid Disorders and Euthyroidism: A Cross-Sectional Exploratory Analysis from the ELSA-Brasil Study Open
Background: Recently, a new biomarker index that reflects inflammation and protein energy malnutrition has emerged as a predictor of mortality in cardiovascular diseases. The metabolic vulnerability index (MVX) derives from blood-based inf…
View article: Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease
Primary Prevention Aspirin, Lipoprotein(a), and Cardiorenal Outcomes in Chronic Kidney Disease Open
Individuals with CKD and elevated Lp(a) without clinical CVD may derive net benefit from low-dose aspirin for the primary prevention of MI and ESRD.
View article: LDL-C targets based on coronary artery calcium: advancing Figure 6 from the 2022 American college of cardiology expert consensus decision pathway
LDL-C targets based on coronary artery calcium: advancing Figure 6 from the 2022 American college of cardiology expert consensus decision pathway Open
The approach to LDL-C management in primary prevention has shifted from lipid-centric strategies to personalized, risk-based frameworks. However, the binary distinction between primary and secondary prevention may overlook individuals with…
View article: Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort
Baseline Cardiac Biomarker Levels as Predictors of Cancer Risk in the MESA Cohort Open
In the MESA cohort, higher baseline levels of hs-cTnT and NT-proBNP predicted an increased risk of incident cancer, with no significant differences by race/ethnicity or sex.
View article: Sex-Specific Coronary Artery Calcium Percentiles Across South Asian Adults
Sex-Specific Coronary Artery Calcium Percentiles Across South Asian Adults Open
These data address the current knowledge gap regarding the distribution of CAC scores among SAUS adults. Utilizing these CAC percentiles in the clinical assessment of ASCVD risk may enhance personalized interpretation of CAC scoring and gu…
View article: Corrigendum to “Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden” [American Journal of Preventive Cardiology 21 (2025) 100916]
Corrigendum to “Association of thoracic aortic calcium with incident cardiovascular disease and all-cause mortality across the spectrum of coronary artery calcium burden” [American Journal of Preventive Cardiology 21 (2025) 100916] Open
[This corrects the article DOI: 10.1016/j.ajpc.2024.100916.].
View article: Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study
Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study Open
Rationale: Increased risk of coronavirus disease (COVID-19) hospitalization and death has been reported among patients with clinical lung disease. Objective: To test the association of objective measures of prepandemic lung function and st…
View article: Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices
Physical Activity, Sleep, and Quality of Life in Pulmonary Arterial Hypertension: Novel Insights From Wearable Devices Open
Reduced functional capacity and poor sleep quality are common in pulmonary arterial hypertension (PAH). Wearable devices are an emerging, user‐friendly tool to capture activity and sleep information. We aimed to determine whether Fitbit‐de…
View article: Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review
Topological Data Analysis in the Assessment of Coronary Atherosclerosis: A Comprehensive Narrative Review Open
Plaque build-up in the coronary arteries can restrict blood flow or become unstable and contribute to cardiovascular events. Evaluating these plaques is essential for cardiovascular risk stratification and determining the most appropriate …
View article: Inflammatory markers and calcification of coronary arteries, aorta and cardiac valves: Findings from the atherosclerosis risk in communities study
Inflammatory markers and calcification of coronary arteries, aorta and cardiac valves: Findings from the atherosclerosis risk in communities study Open
Both hs-CRP and galectin-3 were associated with calcification of some but not all vascular beds tested, suggesting potentially unique atherosclerotic pathophysiology across different vascular beds. Robust associations of inflammatory marke…