Jean Bourbeau
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View article: Perspectives of Individuals With Long COVID on Virtual Physical Rehabilitation: A Qualitative Study
Perspectives of Individuals With Long COVID on Virtual Physical Rehabilitation: A Qualitative Study Open
View article: Breathlessness Abnormality Is Best Assessed at Peak Exercise During Incremental Cardiopulmonary Cycle Exercise Testing
Breathlessness Abnormality Is Best Assessed at Peak Exercise During Incremental Cardiopulmonary Cycle Exercise Testing Open
Abnormal breathlessness is uncovered and should be assessed at peak exercise during symptom-limited incremental CPET. These findings inform symptom assessment in research and clinical practice.
View article: Anxiety and depression impact exertional breathlessness in daily life and during exercise testing: the CanCOLD study
Anxiety and depression impact exertional breathlessness in daily life and during exercise testing: the CanCOLD study Open
Background Exertional breathlessness is a major limiting symptom that often coexists with anxiety and depression. We tested the hypothesis that anxiety and depression negatively impact exertional breathlessness in both daily life and durin…
View article: Meta-Analysis Should Not Be Simply Conducted By Default: Biologic Therapy for Chronic Obstructive Pulmonary Disease
Meta-Analysis Should Not Be Simply Conducted By Default: Biologic Therapy for Chronic Obstructive Pulmonary Disease Open
View article: Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation
Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation Open
View article: Clinically important deterioration in a mild–moderate COPD population
Clinically important deterioration in a mild–moderate COPD population Open
Introduction Clinically important deterioration (CID), a composite of exacerbation, declines in lung function and health status has been studied as an indicator of disease worsening in moderate–severe COPD clinical populations. We assessed…
View article: Phenotyping Exertional Breathlessness Using Cardiopulmonary Cycle Exercise Testing in People With Chronic Airflow Limitation
Phenotyping Exertional Breathlessness Using Cardiopulmonary Cycle Exercise Testing in People With Chronic Airflow Limitation Open
Our results show that exertional breathlessness phenotyped in relationship to V'O2 and V'E using normative reference equations enables multivariable analyses of underlying symptom mechanisms and associated clinical ch…
View article: COPD Exacerbations, Air Pollutant Fluctuations, and Individual-Level Factors in the Pandemic Era
COPD Exacerbations, Air Pollutant Fluctuations, and Individual-Level Factors in the Pandemic Era Open
Ox exposure was consistently associated with symptom-based COPD exacerbations, and female gender, co-morbid asthma, and blood eosinophilia were found to be relevant risk factors.
View article: Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study
Identification and management of cardiopulmonary risk in patients with chronic obstructive pulmonary disease: a multidisciplinary consensus and modified Delphi study Open
Aims Cardiovascular disease is a common comorbidity in chronic obstructive pulmonary disease. Yet, cardiovascular disease and risk are underdiagnosed in chronic obstructive pulmonary disease and are often undertreated, increasing the risk …
View article: Lung structure and function, post-treatment, in strictly defined subclinical pulmonary tuberculosis: a prospective cohort study in Canada
Lung structure and function, post-treatment, in strictly defined subclinical pulmonary tuberculosis: a prospective cohort study in Canada Open
Using Global Lung Initiative 2021 reference equations, a restrictive lung function defect, albeit usually mild, is not uncommon post-treatment, in strictly defined subclinical pulmonary tuberculosis patients in Canada https://bit.ly…
View article: Expiration CT Gas Trapping Measures with Texture-Based Radiomics Improves Association with Lung Function and Lung Function Decline in COPD
Expiration CT Gas Trapping Measures with Texture-Based Radiomics Improves Association with Lung Function and Lung Function Decline in COPD Open
Full-expiratory CT texture-based radiomics improves model performance when used in combination with conventional gas-trapping measurements for lung function and lung function decline, COPD classification and presence of visual gas-trapping.
View article: Utility of diaphragm dome height as a marker of operational lung volume changes, disease burden and exacerbations in patients with mild-to-moderate COPD: an observational study within the CanCOLD cohort
Utility of diaphragm dome height as a marker of operational lung volume changes, disease burden and exacerbations in patients with mild-to-moderate COPD: an observational study within the CanCOLD cohort Open
Background Dynamic hyperinflation is central to dyspnoea, exercise limitation and exacerbations in COPD. While studied previously in moderate-to-severe COPD, the relevance of diaphragm dome height (DDH) on clinically important outcomes has…
View article: Upper-lobe CT imaging features improve prediction of lung function decline in COPD
Upper-lobe CT imaging features improve prediction of lung function decline in COPD Open
Background It is unknown whether prediction models for lung function decline using computed tomography (CT) imaging-derived features from the upper lobes improve performance compared with globally derived features in individuals at risk of…
View article: GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD
GOLD Science Committee recommendations for the use of pre- and post-bronchodilator spirometry for the diagnosis of COPD Open
The Global Initiative for Chronic Obstructive Lung Disease (GOLD) report states that the diagnosis of COPD should be considered in individuals with chronic respiratory symptoms and/or exposure to risk factors. Forced spirometry demonstrati…
View article: Identifying Abnormal Exertional Breathlessness in COPD
Identifying Abnormal Exertional Breathlessness in COPD Open
View article: Asthma coexistence does not worsen or accelerate the decline in exercise capacity in COPD
Asthma coexistence does not worsen or accelerate the decline in exercise capacity in COPD Open
Despite worse clinical and patient-reported outcomes, older adults with asthma-COPD coexistence do not have more severely impaired nor a faster rate of decline in exercise capacity compared to those with COPD alone https://bit.ly/3B…
View article: Peak Inspiratory Flow and Inhaler Prescription Strategies in a Specialized COPD Clinical Program
Peak Inspiratory Flow and Inhaler Prescription Strategies in a Specialized COPD Clinical Program Open
View article: Relationship of Pulmonary Vascular Structure and Function With Exercise Capacity in Health and COPD
Relationship of Pulmonary Vascular Structure and Function With Exercise Capacity in Health and COPD Open
View article: Aggravating mechanisms from COVID-19
Aggravating mechanisms from COVID-19 Open
View article: Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation
Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation Open
View article: A Multi-Specialty Delphi Consensus on Assessing and Managing Cardiopulmonary Risk in Patients with COPD
A Multi-Specialty Delphi Consensus on Assessing and Managing Cardiopulmonary Risk in Patients with COPD Open
Based on the consensus scores, 9 key recommendations were proposed by the steering group. These focus on the need to comprehensively risk stratify and manage COPD patients to help prevent exacerbations. Consensus within this study provides…
View article: Reply to Jankowich: PRISm: What?s in a Name?
Reply to Jankowich: PRISm: What?s in a Name? Open
View article: Basic implications on three pathways associated with SARS-CoV-2
Basic implications on three pathways associated with SARS-CoV-2 Open
View article: Sex‐related differences in pulmonary vascular volume distribution
Sex‐related differences in pulmonary vascular volume distribution Open
Pulmonary arterial hypertension affects females more frequently than males, and there are known sex‐related differences in the lungs. However, normal sex‐related differences in pulmonary vascular structure remain incompletely described. We…
View article: Interferon upregulation as the cause of Alzheimer’s disease
Interferon upregulation as the cause of Alzheimer’s disease Open
Dapsone (4,4′-diamino diphenyl sulfone, DDS) is an acetylation agent, anticatalysis for Alzheimer’s disease (AD) exacerbation in the previous report. We analyzed the viral respiratory disease (VRD) (+)/(−) and DDS (+)/(−) groups with the I…
View article: Increasing exercise capacity and physical activity in the COPD patient
Increasing exercise capacity and physical activity in the COPD patient Open
Higher levels of exercise capacity and physical activity are desired outcomes in the comprehensive management of the COPD patient. In addition, improvements in exercise capacity and physical activity are instrumental to optimising other im…
View article: Optimizing Pharmacotherapy Management of Chronic Obstructive Pulmonary Disease: Don’t Miss the Forest for the Trees
Optimizing Pharmacotherapy Management of Chronic Obstructive Pulmonary Disease: Don’t Miss the Forest for the Trees Open
"Optimizing Pharmacotherapy Management of COPD: Don't Miss the Forest for the Trees." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Classifying Future Healthcare Utilization in COPD Using Quantitative CT Lung Imaging and Two-Step Feature Selection via Sparse Subspace Learning with the CanCOLD Study
Classifying Future Healthcare Utilization in COPD Using Quantitative CT Lung Imaging and Two-Step Feature Selection via Sparse Subspace Learning with the CanCOLD Study Open
The hybrid feature selection method identified the most discriminative features for classifying individuals with and without future healthcare utilization, and increased the accuracy compared to other state-of-the-art approaches.
View article: Cannabis smoking is associated with advanced epigenetic age
Cannabis smoking is associated with advanced epigenetic age Open
Current cannabis smoking is significantly associated with faster peripheral blood epigenetic age acceleration; interestingly, cannabis smoking cessation is shown to normalise this age acceleration signal. https://bit.ly/3x7s2CU
View article: The picture theory of seven pathways associated with COVID-19 in the real world
The picture theory of seven pathways associated with COVID-19 in the real world Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated diseases. Interactions between the host and virus govern induction, resulting in multiorgan impacts. In 2021, as normal life was challenging during the pa…