Robert Boyle
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View article: Food allergy severity across the world: A World Allergy Organization international survey
Food allergy severity across the world: A World Allergy Organization international survey Open
With wide global disparities in access to diagnostic and therapeutic tools for food allergies, this condition entails a vast healthcare and economic commitment. The percentage of patients receiving a high severity diagnosis using DEFASE co…
View article: Standardizing outcomes in food allergy research: aligning clinical trials with patient priorities
Standardizing outcomes in food allergy research: aligning clinical trials with patient priorities Open
Purpose of review This review explores the clinical outcomes used in immunoglobulin E (IgE)-mediated food allergy (FA) intervention studies, emphasizing unmet need for patient-centred outcomes. Standardizing outcome measurement is critical…
View article: Mycotic aneurysms due to Burkholderia pseudomallei in Far North Queensland, tropical Australia: A case series and review of the literature
Mycotic aneurysms due to Burkholderia pseudomallei in Far North Queensland, tropical Australia: A case series and review of the literature Open
Since 2019, Burkholderia pseudomallei has been the most common cause of mycotic aneurysm at Cairns Hospital in tropical Australia. Among 233 culture-confirmed cases of melioidosis since this time, 8 (3.4 %) were diagnosed with a mycotic an…
View article: Food Allergy Test‐Guided Dietary Advice for Children With Atopic Dermatitis: A Consensus Study
Food Allergy Test‐Guided Dietary Advice for Children With Atopic Dermatitis: A Consensus Study Open
Background The use of blood specific IgE or skin prick tests (SPT) to guide dietary exclusions for disease control in children with atopic dermatitis (AD) is controversial. We undertook a consensus exercise on how to interpret SPT results …
View article: Adrenaline Auto‐Injectors for Preventing Fatal Anaphylaxis
Adrenaline Auto‐Injectors for Preventing Fatal Anaphylaxis Open
Anaphylaxis affects up to 5% of people during their lifetime. Although anaphylaxis usually resolves without long‐term physical consequences, it can result in anxiety and quality of life impairment. Rarely and unpredictably, community anaph…
View article: Whole Exome Sequencing Identifies Epithelial and Immune Dysfunction‐Related Biomarkers in Food Protein‐Induced Enterocolitis Syndrome
Whole Exome Sequencing Identifies Epithelial and Immune Dysfunction‐Related Biomarkers in Food Protein‐Induced Enterocolitis Syndrome Open
Background Food protein‐induced enterocolitis syndrome (FPIES) is a food allergy primarily affecting infants, often leading to vomiting and shock. Due to its poorly understood pathophysiology and lack of specific biomarkers, diagnosis is f…
View article: Time Trends, Regional Variation and Associations of Low‐Allergy Formula Prescribing in England
Time Trends, Regional Variation and Associations of Low‐Allergy Formula Prescribing in England Open
Background Cow's milk allergy (CMA) overdiagnosis appears to be increasing and is associated with excessive low‐allergy formula prescription. We evaluated recent trends and regional variation in low‐allergy formula prescribing for CMA in E…
View article: Topical Anti‐Inflammatory Treatments for Eczema: A Cochrane Systematic Review and Network Meta‐Analysis
Topical Anti‐Inflammatory Treatments for Eczema: A Cochrane Systematic Review and Network Meta‐Analysis Open
Objective Eczema is the most burdensome skin condition worldwide and topical anti‐inflammatory treatments are commonly used to control symptoms. The relative effectiveness and safety of different topical anti‐inflammatory treatments is unc…
View article: Educational and psychological interventions for managing atopic dermatitis (eczema)
Educational and psychological interventions for managing atopic dermatitis (eczema) Open
In-person, individual education, as an adjunct to conventional topical therapy, may reduce short-term eczema signs compared to standard care, but there is no information on eczema symptoms, quality of life or long-term outcomes. Group educ…
View article: Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial
Infant Feeding and Weight Trajectories in the Eat, Sleep, Console Trial Open
Importance Infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console (ESC) care approach receive less pharmacologic treatment and have shorter hospital stays compared to usual care with the Finnegan Neo…
View article: Topical anti-inflammatory treatments for eczema: network meta-analysis
Topical anti-inflammatory treatments for eczema: network meta-analysis Open
Potent TCS, JAK inhibitors and tacrolimus 0.1% were consistently ranked as amongst the most effective topical anti-inflammatory treatments for eczema and PDE-4 inhibitors as amongst the least effective. Mild TCS and tapinarof 1% were ranke…
View article: Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT
Emollient application from birth to prevent eczema in high-risk children: the BEEP RCT Open
Background Atopic eczema is a common childhood skin problem linked with asthma, food allergy and allergic rhinitis that impairs quality of life. Objectives To determine whether advising parents to apply daily emollients in the first year c…
View article: Prevalence and risk factors for milk allergy overdiagnosis in the BEEP trial cohort
Prevalence and risk factors for milk allergy overdiagnosis in the BEEP trial cohort Open
Background Cow's milk allergy (CMA) overdiagnosis in young children appears to be increasing and has not been well characterised. We used a clinical trial population to characterise CMA overdiagnosis and identify individual‐level and prima…