J. Douglas Bremner
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View article: Factors affecting clinical trial participation in people with interstitial lung disease – a qualitative study
Factors affecting clinical trial participation in people with interstitial lung disease – a qualitative study Open
Background Clinical trials are the best method for evaluating new treatments for people with interstitial lung disease (ILD). However, recruitment in ILD clinical trials is often challenging. Certain trial characteristics may influence wil…
View article: Equity in pulmonary rehabilitation delivery: a systematic review and meta-analysis
Equity in pulmonary rehabilitation delivery: a systematic review and meta-analysis Open
Background Barriers to delivery of pulmonary rehabilitation are not evenly distributed across people with chronic lung disease. The aim of this systematic review was to evaluate equity in pulmonary rehabilitation delivery and outcomes, in …
View article: Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort
Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort Open
Importance Olfactory dysfunction is common after SARS-CoV-2 infection and has been associated with cognitive loss in other conditions. Formal testing is needed to characterize the presence, severity, and patterns of olfactory dysfunction. …
View article: Real-life Psychological Experiences and Cardiac Autonomic Physiology among Survivors of a Myocardial Infarction in Midlife
Real-life Psychological Experiences and Cardiac Autonomic Physiology among Survivors of a Myocardial Infarction in Midlife Open
Middle-aged women with ischemic heart disease have a higher burden of psychosocial factors compared with male counterparts. Data on daily life stress and autonomic physiology could help guide targeted interventions. We studied 302 individu…
View article: Positron Tomographic Emission Study of Olfactory Induced Emotional Recall in Veterans with and without Combat-Related Post Traumatic Stress Disorder
Positron Tomographic Emission Study of Olfactory Induced Emotional Recall in Veterans with and without Combat-Related Post Traumatic Stress Disorder Open
Memory for odors is often associated with highly emotional experiences, and odors have long been noted by clinicians to be precipitants of trauma symptoms in posttraumatic stress disorder (PTSD). Primitive brain systems involved in fear re…
View article: Prescreening depression using wearable electrocardiogram and photoplethysmogram data from a psycholinguistic experiment
Prescreening depression using wearable electrocardiogram and photoplethysmogram data from a psycholinguistic experiment Open
Objective. Depression is a prevalent mental health disorder that significantly impacts well-being and quality of life. This study investigates the relationship between depression and cardiovascular function, exploring time-series features …
View article: A Psycholinguistics Protocol with Simultaneous Multimodal Physiological Data Collection for Individualized Pre-Screening Depressive Disorders v2
A Psycholinguistics Protocol with Simultaneous Multimodal Physiological Data Collection for Individualized Pre-Screening Depressive Disorders v2 Open
We present the PRESCRIBE (Preconscious Signal Compilation for Robust and Individualized Belief Evaluation) protocol, a structured, multimodal data collection framework designed to investigate neurophysiological and autonomic responses asso…
View article: A Psycholinguistics Protocol with Simultaneous Multimodal Physiological Data Collection for Individualized Pre-Screening Depressive Disorders v1
A Psycholinguistics Protocol with Simultaneous Multimodal Physiological Data Collection for Individualized Pre-Screening Depressive Disorders v1 Open
We present the PRESCRIBE (Preconscious Signal Compilation for Robust and Individualized Belief Evaluation) protocol, a structured, multimodal data collection framework designed to investigate neurophysiological and autonomic responses asso…
View article: Heightened Risk of Myocardial Ischemia with Mental Stress Among Black Women Survivors of a Myocardial Infarction in Midlife
Heightened Risk of Myocardial Ischemia with Mental Stress Among Black Women Survivors of a Myocardial Infarction in Midlife Open
Background Stark disparities in the outcome of myocardial infarction (MI) persist, with large unexplained variations affecting younger Black women. Mental stress induced myocardial ischemia (MSIMI) is an emerging mechanistic pathway that m…
View article: Kidney Function Following COVID-19 in Children and Adolescents
Kidney Function Following COVID-19 in Children and Adolescents Open
Importance It remains unclear whether children and adolescents with SARS-CoV-2 infection are at heightened risk for long-term kidney complications. Objective To investigate whether SARS-CoV-2 infection is associated with an increased risk …
View article: Accrued reductions in heart rate following transcutaneous vagal nerve stimulation in adults with posttraumatic stress disorder
Accrued reductions in heart rate following transcutaneous vagal nerve stimulation in adults with posttraumatic stress disorder Open
Background Post-Traumatic Stress Disorder (PTSD) is a condition marked by chronic autonomic dysregulation, including heightened arousal and increased heart rate, contributing to a higher risk of cardiovascular disease (CVD). tcVNS has been…
View article: Cardiovascular Reactivity to Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease
Cardiovascular Reactivity to Mental Stress and Adverse Cardiovascular Outcomes in Patients With Coronary Artery Disease Open
Background Acute psychological stress may induce physiological changes predisposing individuals to adverse health outcomes through hemodynamic and vascular effects. We studied the association between the aggregated stress‐induced changes i…
View article: 2024 Update of the RECOVER-Adult Long COVID Research Index
2024 Update of the RECOVER-Adult Long COVID Research Index Open
Importance Classification of persons with long COVID (LC) or post–COVID-19 condition must encompass the complexity and heterogeneity of the condition. Iterative refinement of the classification index for research is needed to incorporate n…
View article: Posttraumatic Stress Disorder and the Risk of Heart Failure Hospitalizations Among Individuals With Coronary Artery Disease
Posttraumatic Stress Disorder and the Risk of Heart Failure Hospitalizations Among Individuals With Coronary Artery Disease Open
BACKGROUND: Posttraumatic stress disorder (PTSD) is associated with maladaptive dysregulation of stress response systems, which could lead to an increased risk of heart failure. We investigated whether PTSD was independently associated wit…
View article: Autonomic reactivity to mental stress is associated with cardiovascular mortality
Autonomic reactivity to mental stress is associated with cardiovascular mortality Open
Aims The mechanisms linking acute psychological stress to cardiovascular disease (CVD) mortality are incompletely understood. We studied the relationship of electrocardiographic measures of autonomic dysfunction during acute mental stress …
View article: A novel GWAS locus influences microvascular response to mental stress and predicts adverse cardiovascular events
A novel GWAS locus influences microvascular response to mental stress and predicts adverse cardiovascular events Open
Excessive peripheral microvascular constriction during acute psychological stress reflects similar changes in coronary blood flow and is a predictor of adverse cardiovascular outcomes. Among individuals with coronary artery disease (CAD), …
View article: Investigating Ultra-Short-Term Heart Rate Variability as an Indicator of Craving in Recently Treated Patients with Opioid Use Disorder<sup>*</sup>
Investigating Ultra-Short-Term Heart Rate Variability as an Indicator of Craving in Recently Treated Patients with Opioid Use Disorder<sup>*</sup> Open
Induced craving frequently leads to relapse in patients with a history of opioid use disorder (OUD). Quantifying the physiological manifestations of craving can enable caregivers of patients with OUD to continuously monitor craving and thu…
View article: Posttraumatic Stress Disorder and Obstructive Sleep Apnea in Twins
Posttraumatic Stress Disorder and Obstructive Sleep Apnea in Twins Open
Importance Obstructive sleep apnea (OSA) is a common condition in older adult (aged &gt;65 years) populations, but more mechanistic research is needed to individualize treatments. Previous evidence has suggested an association between …
View article: Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease
Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease Open
BACKGROUND: Mental stress–induced myocardial ischemia (MSIMI) is associated with adverse cardiovascular outcomes in individuals with coronary artery disease, but the mechanisms underlying this phenomenon are unknown. We examined the relati…
View article: Quantifying Posttraumatic Stress Disorder Symptoms During Traumatic Memories Using Interpretable Markers of Respiratory Variability
Quantifying Posttraumatic Stress Disorder Symptoms During Traumatic Memories Using Interpretable Markers of Respiratory Variability Open
These findings encourage future studies outside the clinic, where interpretable markers of respiratory variability are used to track hyperarousal.
View article: Hemodynamic Reactivity to Mental Stress and Cognitive Function in Coronary Artery Disease
Hemodynamic Reactivity to Mental Stress and Cognitive Function in Coronary Artery Disease Open
Objective People with coronary artery disease (CAD) are at higher risk of cognitive impairment than those without CAD. Psychological stress is a risk factor for both conditions, and assessing the hemodynamic reactivity to mental stress cou…
View article: Heart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study
Heart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study Open
Background Autonomic function can be measured noninvasively using heart rate variability (HRV), which indexes overall sympathovagal balance. Deceleration capacity (DC) of heart rate is a more specific metric of vagal modulation. Higher val…
View article: Impedance cardiogram based exploration of cardiac mechanisms in post‐traumatic stress disorder during trauma recall
Impedance cardiogram based exploration of cardiac mechanisms in post‐traumatic stress disorder during trauma recall Open
Post‐traumatic stress disorder (PTSD) is an independent risk factor for developing heart failure; however, the underlying cardiac mechanisms are still elusive. This study aims to evaluate the real‐time effects of experimentally induced PTS…
View article: Association Between Symptoms of Chronic Psychological Distress and Myocardial Ischemia Induced by Mental Stress in Patients With Coronary Artery Disease
Association Between Symptoms of Chronic Psychological Distress and Myocardial Ischemia Induced by Mental Stress in Patients With Coronary Artery Disease Open
Background Mental stress–induced myocardial ischemia is a frequent phenomenon in patients with coronary artery disease and is associated with a greater risk of future cardiovascular events. The association between chronic symptoms of psych…