J. Brent Friesen
YOU?
Author Swipe
View article: DESIGNER fraction concept unmasks minor bioactive constituents in red clover (Trifolium pratense L.)
DESIGNER fraction concept unmasks minor bioactive constituents in red clover (Trifolium pratense L.) Open
View article: Geraniol-Derived Monoterpenoid Glucosides from <i>Rhodiola rosea</i>: Resolving Structures by QM-HifSA Methodology
Geraniol-Derived Monoterpenoid Glucosides from <i>Rhodiola rosea</i>: Resolving Structures by QM-HifSA Methodology Open
Monoterpenoids are integral to the chemical composition of the widely used adaptogenic dietary supplement Rhodiola rosea. The present study expands the chemical space and stereochemical information about these taxon-specific constit…
View article: Pharmaceutical analysis by NMR can accommodate strict impurity thresholds: The case of choline
Pharmaceutical analysis by NMR can accommodate strict impurity thresholds: The case of choline Open
The ICH guidelines recommend reporting thresholds for regular impurities in drug substances at the level of 0.05% or 0.03% (w/w) depending on the maximum daily intake. Therefore, any instrumental method of analysis applicable to the impuri…
View article: Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses
Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses Open
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ongoing coronavirus disease 2019 (COVID-19) pandemic underscores the need for new treatments. Here, we report that cannabidiol (CBD) inhibits infection of SARS-…
View article: Selective Preparation and High Dynamic-Range Analysis of Cannabinoids in “CBD Oil” and Other <i>Cannabis sativa</i> Preparations
Selective Preparation and High Dynamic-Range Analysis of Cannabinoids in “CBD Oil” and Other <i>Cannabis sativa</i> Preparations Open
Much confusion exists about the chemical composition of widely sold Cannabis sativa products that utilize the cannabidiol (CBD) acronym and related terms such as "CBD oil", "CBD plus hemp oil", "full spectrum CBD", "broad spectrum C…
View article: Do Certain Flavonoid IMPS Have a Vital Function?
Do Certain Flavonoid IMPS Have a Vital Function? Open
Flavonoids are a vast group of metabolites that are essential for vascular plant physiology and, thus, occur ubiquitously in plant-based/-derived foods. The solitary designation of thousands of known flavonoids hides the fact that their me…
View article: Investigation of red clover (Trifolium pratense) isoflavonoid residual complexity by off-line CCS-qHNMR
Investigation of red clover (Trifolium pratense) isoflavonoid residual complexity by off-line CCS-qHNMR Open
View article: Tandem of Countercurrent Separation and qHNMR Enables Gravimetric Analyses: Absolute Quantitation of the <i>Rhodiola rosea</i> Metabolome
Tandem of Countercurrent Separation and qHNMR Enables Gravimetric Analyses: Absolute Quantitation of the <i>Rhodiola rosea</i> Metabolome Open
Off-line combination of countercurrent separation (CCS) and quantitative 1H NMR (qHNMR) methodologies enabled the systematic dissection and gravimetric quantification of a chemically complex Rhodiola rosea crude extract (…
View article: Silica Gel-mediated Oxidation of Prenyl Motifs Generates Natural Product-Like Artifacts
Silica Gel-mediated Oxidation of Prenyl Motifs Generates Natural Product-Like Artifacts Open
Prenyl moieties are commonly encountered in the natural products of terpenoid and mixed biosynthetic origin. The reactivity of unsaturated prenyl motifs is less recognized and shown here to affect the acyclic Rhodiola rosea monoterpene gly…
View article: Auto-hydrolysis of red clover as “green” approach to (iso)flavonoid enriched products
Auto-hydrolysis of red clover as “green” approach to (iso)flavonoid enriched products Open
View article: The Untargeted Capability of NMR Helps Recognizing Nefarious Adulteration in Natural Products
The Untargeted Capability of NMR Helps Recognizing Nefarious Adulteration in Natural Products Open
Curcuma longa (turmeric) has an extensive history of ethnomedical use for common ailments, and "curcumin"-containing dietary supplements (CDS) are a highly visible portion of today's self-medication market. Owing to raw material cos…
View article: Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response
Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response Open
The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric can…
View article: Isolation and Pharmacological Characterization of Six Opioidergic <i>Picralima nitida</i> Alkaloids
Isolation and Pharmacological Characterization of Six Opioidergic <i>Picralima nitida</i> Alkaloids Open
The seeds of the akuamma tree (Picralima nitida) have been used as a traditional treatment for pain and fever. Previous studies have attributed these effects to a series of indole alkaloids found within the seed extracts; however, t…
View article: The Untargeted Capability of NMR Recognizes Adulterated Natural Products
The Untargeted Capability of NMR Recognizes Adulterated Natural Products Open
Curcuma longa (turmeric) has a long ethnomedical background for common ailments, and Dietary Supplements (DS) labelled as “Curcumin” (CDS) are a highly visible portion of today’s selfmedication market. Due to cost pressure, these CDS produ…
View article: The Untargeted Capability of NMR Recognizes Adulterated Natural Products
The Untargeted Capability of NMR Recognizes Adulterated Natural Products Open
Curcuma longa (turmeric) has a long ethnomedical background for common ailments, and Dietary Supplements (DS) labelled as “Curcumin” (CDS) are a highly visible portion of today’s selfmedication market. Due to cost pressure, these CDS produ…
View article: 333_Syncumin
333_Syncumin Open
Raw data associated with the publication "The Untargeted Capability of NMR Recognizes Adulterated Natural Products"
View article: Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids
Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids Open
The seeds of the akuamma tree (Picralima nitida) have been used as a traditional treatment for pain and fever. Previous studies have attributed these effects to a series of indole alkaloids found within the seed extracts; however, t…
View article: Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids
Isolation and Pharmacological Characterization of Six Opioidergic Picralima nitida Alkaloids Open
The seeds of the akuamma tree ( Picralima nitida ) have been used as a traditional treatment for pain and fever. Previous studies have attributed these effects to a series of indole alkaloids found within the seed extracts; however, these …
View article: Quantum mechanical NMR full spin analysis in pharmaceutical identity testing and quality control
Quantum mechanical NMR full spin analysis in pharmaceutical identity testing and quality control Open
View article: The Essential Medicinal Chemistry of Cannabidiol (CBD)
The Essential Medicinal Chemistry of Cannabidiol (CBD) Open
© 2020 American Chemical Society. All rights reserved. This Perspective of the published essential medicinal chemistry of cannabidiol (CBD) provides evidence that the popularization of CBD-fortified or CBD-labeled health products and CBD-a…
View article: Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides from <i>Rhodiola rosea</i>
Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides from <i>Rhodiola rosea</i> Open
NMR- and MS-guided metabolomic mining for new phytoconstituents from a widely used dietary supplement, Rhodiola rosea, yielded two new (+)-myrtenol glycosides, 1 and 2, and two new cuminol glycosides, 3 and 4…
View article: Selective Chlorophyll Removal Method to “Degreen” Botanical Extracts
Selective Chlorophyll Removal Method to “Degreen” Botanical Extracts Open
Chlorophylls are present in all extracts from the aerial parts of green plant materials. Chlorophylls may act as in vitro bioassay nuisance compounds, possibly preventing the reproducibility and accurate measurement of readouts due to thei…
View article: Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides from Rhodiola Rosea
Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides from Rhodiola Rosea Open
NMR- and MS-guided metabolomic mining for new phytoconstituents from a widely used dietary supplement, Rhodiola rosea, yielded two new (+)-myrtenol glycosides, 1 and 2, and two new cuminol glycosides (3 and 4…
View article: Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides from Rhodiola Rosea
Quantum Mechanics-Based Structure Analysis of Cyclic Monoterpene Glycosides from Rhodiola Rosea Open
NMR- and MS-guided metabolomic mining for new phytoconstituents from a widely used dietary supplement, Rhodiola rosea , yielded two new (+)-myrtenol glycosides, 1 and 2 , and two new cuminol glycosides ( 3 and 4 ), along with three known a…
View article: NMR_Chlorophylls.zip
NMR_Chlorophylls.zip Open
Raw 1H NMR data of chlorophylls a, b, pheophorbide a, and phytol acquired at 400 MHz in CDCl3 in 3 mm NMR tubes. Chlorophyll a 1H NMR spectrum was also acquired at 900 MHz.
View article: Manuscript_ChloroKOE_data_figures.zip
Manuscript_ChloroKOE_data_figures.zip Open
Raw and experimental data (HPTLC, NMR, CPC, (U)HPLC-UV) used to prepare figures 2-7 of the manuscript "Selective Chlorophyll Removal Method to "Degreen" Botanical Extracts"
View article: SI_ChloroKOE_data_figures.zip
SI_ChloroKOE_data_figures.zip Open
Raw and experimental (HPTLC, NMR, CPC, (U)HPLC-UV) data used to prepare each figure presented in the supporting information document for the manuscript "Selective Chlorophyll Removal Method to "Degreen" Botanical Extracts"
View article: 295_ChloroKOE
295_ChloroKOE Open
This folder contains the collected data (HPTLC, NMR, CPC, (U)HPLC-UV) associated with each figure of the publication entitled "Selective Chlorophyll Removal Method to "Degreen" Botanical Extracts".
View article: Studying Mass Balance and the Stability of (<i>Z</i>)-Ligustilide from <i>Angelica sinensis</i> Helps to Bridge a Botanical Instability–Bioactivity Chasm
Studying Mass Balance and the Stability of (<i>Z</i>)-Ligustilide from <i>Angelica sinensis</i> Helps to Bridge a Botanical Instability–Bioactivity Chasm Open
Numerous reports assigning (Z)-ligustilide (1) the role of a major bioactive principle in Apiaceae botanicals are called into question by the recurrent demonstrations of 1 being an unstable, rapidly degrading compound, ultimately leading t…
View article: Preparation of DESIGNER extracts of red clover (Trifolium pratense L.) by centrifugal partition chromatography
Preparation of DESIGNER extracts of red clover (Trifolium pratense L.) by centrifugal partition chromatography Open