John‐John B. Schnog
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View article: Increasing the focus on critical appraisal of trials and financial conflict of interest in medical training programs: a perspective from oncology
Increasing the focus on critical appraisal of trials and financial conflict of interest in medical training programs: a perspective from oncology Open
Improving medical education programs is key for achieving true value-based healthcare. Worldwide several approaches have been proposed for adapting current medical curricula in order to better foster modern medical professionals as agents …
View article: Moving forward from spleen response as an endpoint in randomized controlled trials in myelofibrosis
Moving forward from spleen response as an endpoint in randomized controlled trials in myelofibrosis Open
Anticancer drugs should make patients live longer and/or feel better. Ideally, endpoints of cancer randomized controlled trials (RCTs) should demonstrate that a drug leads to an increase in overall survival (OS) and/or improvement in quali…
View article: Characteristics of professional society oncological drug evaluation in the Netherlands from 2016 to 2020: A retrospective analysis
Characteristics of professional society oncological drug evaluation in the Netherlands from 2016 to 2020: A retrospective analysis Open
View article: Design issues with lutetium-177 PSMA-617 registration studies that bias the outcome of the experimental arm reflect an increasing misalignment of contemporary oncology trials with true patient benefit
Design issues with lutetium-177 PSMA-617 registration studies that bias the outcome of the experimental arm reflect an increasing misalignment of contemporary oncology trials with true patient benefit Open
View article: Pharmaceutical company funding of cancer patient advocacy organizations in the Netherlands
Pharmaceutical company funding of cancer patient advocacy organizations in the Netherlands Open
View article: Pharmaceutical Industry Payments to Medical Oncologists in the Netherlands: Trends and Patterns Provided by an Open-Access Transparency Data Set
Pharmaceutical Industry Payments to Medical Oncologists in the Netherlands: Trends and Patterns Provided by an Open-Access Transparency Data Set Open
PURPOSE Health care expenditure related to oncologic treatments is skyrocketing although many treatments offer marginal, if any, clinical benefit. Financial conflicts of interest (fCOI) resulting from pharmaceutical industry (pharma) payme…
View article: Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies
Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies Open
View article: An analytical view of the <scp>BJH</scp> publication of ‘a clinician's view of voxelotor’
An analytical view of the <span>BJH</span> publication of ‘a clinician's view of voxelotor’ Open
In the recent correspondence by Osunkwo et al. voxelotor is praised as an important advance for patients with sickle cell disease (SCD).1 Voxelotor inhibits sickle haemoglobin polymerization by increasing its affinity for oxygen. It has be…
View article: Contemporary oncology trials, drug approvals and the physician-patient relationship
Contemporary oncology trials, drug approvals and the physician-patient relationship Open
View article: An urgent call to raise the bar in oncology
An urgent call to raise the bar in oncology Open
View article: Deep and ongoing response of castrate-resistant prostate cancer on very low-dose enzalutamide in an elderly chemotherapy–naïve patient: a case report
Deep and ongoing response of castrate-resistant prostate cancer on very low-dose enzalutamide in an elderly chemotherapy–naïve patient: a case report Open
View article: Sudden death due to massive bone marrow sequestration crisis in a patient with sickle cell disease
Sudden death due to massive bone marrow sequestration crisis in a patient with sickle cell disease Open
Sickle cell disease (SCD) is a severe hemoglobinopathy characterized by an increased susceptibility to infections, chronic hemolytic anemia and continuous micro-vascular occlusion with acute exacerbations leading to accumulating organ dama…
View article: <scp>N</scp>‐terminal pro‐<scp>B</scp>‐type natriuretic peptide, tricuspid jet flow velocity, and death in adults with sickle cell disease
<span>N</span>‐terminal pro‐<span>B</span>‐type natriuretic peptide, tricuspid jet flow velocity, and death in adults with sickle cell disease Open
Both elevated N-terminal prohormone brain natriuretic peptide (NT-proBNP) levels (>160 pg/mL) and elevated tricuspid regurgitant jet flow velocity (TRV ≥2.5 m/sec) have been related to the presence of (echocardiography defined) pulmonary h…