Juliana C.N. Chan
YOU?
Author Swipe
View article: Efficacy of Mindfulness-Based Interventions on Negative Symptoms in Schizophrenia: A Systematic Review and Meta-Analysis
Efficacy of Mindfulness-Based Interventions on Negative Symptoms in Schizophrenia: A Systematic Review and Meta-Analysis Open
This systematic review and meta-analysis evaluated the efficacy of mindfulness-based interventions (MBIs) in reducing negative symptoms among individuals with schizophrenia spectrum disorders. Following PRISMA guidelines, we analyzed 11 ra…
View article: 198 Ceramide and protein abnormalities in atopic dermatitis versus healthy skin revealed by tape stripping analysis in an Asian cohort
198 Ceramide and protein abnormalities in atopic dermatitis versus healthy skin revealed by tape stripping analysis in an Asian cohort Open
View article: Young-onset hypertension confers higher risk of cardiovascular disease, kidney disease, and all-cause mortality in individuals with type 2 diabetes: a propensity score matched cohort analysis
Young-onset hypertension confers higher risk of cardiovascular disease, kidney disease, and all-cause mortality in individuals with type 2 diabetes: a propensity score matched cohort analysis Open
Objective: The impact of young-onset hypertension(YOH) on cardiovascular and kidney outcomes in people with type 2 diabetes(T2D) has not been systematically studied.Research Design and Methods:This is a retrospective cohort study. We ident…
View article: Young-onset hypertension confers higher risk of cardiovascular disease, kidney disease, and all-cause mortality in individuals with type 2 diabetes: a propensity score matched cohort analysis
Young-onset hypertension confers higher risk of cardiovascular disease, kidney disease, and all-cause mortality in individuals with type 2 diabetes: a propensity score matched cohort analysis Open
Objective: The impact of young-onset hypertension(YOH) on cardiovascular and kidney outcomes in people with type 2 diabetes(T2D) has not been systematically studied.Research Design and Methods:This is a retrospective cohort study. We ident…
View article: Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network
Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network Open
The five-year risk of cancer was higher in those with newly diagnosed type 2 diabetes versus those without. Absolute risk was greater in middle-older age adults, although relative rates were greater amongst younger adults. This persisted a…
View article: Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database
Exploring penetrance of clinically relevant variants in over 800,000 humans from the Genome Aggregation Database Open
Incomplete penetrance, or absence of disease phenotype in an individual with a disease-associated variant, is a major challenge in variant interpretation. Studying individuals with apparent incomplete penetrance can shed light on underlyin…
View article: Trends of lipid-lowering drug utilization, treatment intensity and LDL-C target attainment in adults with diabetes and non-dialysis chronic kidney disease in Hong Kong
Trends of lipid-lowering drug utilization, treatment intensity and LDL-C target attainment in adults with diabetes and non-dialysis chronic kidney disease in Hong Kong Open
View article: Environmental exposure to toxic and essential metals and glucose homeostasis in adolescents: A cross-sectional analysis of the Hong Kong School Children Cohort
Environmental exposure to toxic and essential metals and glucose homeostasis in adolescents: A cross-sectional analysis of the Hong Kong School Children Cohort Open
Environmental exposure to heavy metals is associated with increased risk of type 2 diabetes (T2D). Although T2D in adolescents and young adults is increasingly prevalent, the association between toxic and essential metals and glucose homeo…
View article: A 7‐year prospective analysis of sustained benefits of multicomponent risk assessment and data‐driven care in patients with type 2 diabetes: The Malaysian <scp>JADE</scp> Program
A 7‐year prospective analysis of sustained benefits of multicomponent risk assessment and data‐driven care in patients with type 2 diabetes: The Malaysian <span>JADE</span> Program Open
Aim We evaluated the sustained effects of multicomponent risk assessment and data‐driven care augmented by the web‐based Joint Asia Diabetes Evaluation (JADE) Platform with a built‐in template to guide comprehensive assessment (CA) for ris…
View article: Global challenges in diabetes research and care: which way forward? An appraisal from the EASD Global Council
Global challenges in diabetes research and care: which way forward? An appraisal from the EASD Global Council Open
View article: <b>Effects of dorzagliatin, a glucokinase activator, on α and β- cell function in individuals with impaired and normal glucose tolerance</b>
<b>Effects of dorzagliatin, a glucokinase activator, on α and β- cell function in individuals with impaired and normal glucose tolerance</b> Open
Dorzagliatin is a dual-acting allosteric activator of glucokinase (GCK). Dorzagliatin improved second-phase insulin secretion in individuals with type 2 diabetes and heterozygous carriers of GCK mutations. We investigated the effects of do…
View article: Effects of Dorzagliatin, a Glucokinase Activator, on α- and β-Cell Function in Individuals With Impaired and Normal Glucose Tolerance
Effects of Dorzagliatin, a Glucokinase Activator, on α- and β-Cell Function in Individuals With Impaired and Normal Glucose Tolerance Open
Dorzagliatin is a dual-acting allosteric activator of glucokinase (GCK). Dorzagliatin improved second-phase insulin secretion in individuals with type 2 diabetes and heterozygous carriers of GCK mutations. We investigated the effects of do…
View article: <b>Effects of dorzagliatin, a glucokinase activator, on α and β- cell function in individuals with impaired and normal glucose tolerance</b>
<b>Effects of dorzagliatin, a glucokinase activator, on α and β- cell function in individuals with impaired and normal glucose tolerance</b> Open
Dorzagliatin is a dual-acting allosteric activator of glucokinase (GCK). Dorzagliatin improved second-phase insulin secretion in individuals with type 2 diabetes and heterozygous carriers of GCK mutations. We investigated the effects of do…
View article: Development of a Chinese‐Specific Clinical Model to Predict Maturity‐Onset Diabetes of the Young
Development of a Chinese‐Specific Clinical Model to Predict Maturity‐Onset Diabetes of the Young Open
Aims Accurate identification of individuals with maturity‐onset diabetes of the young (MODY) can support precision diabetes management. However, diagnosing MODY is challenging due to overlapping clinical features with type 2 diabetes. We a…
View article: A novel electronic-health-record based, machine-learning model to predict 1-year risk of fall hospitalisation in older adults: a Hong Kong territory-wide cohort and modelling study
A novel electronic-health-record based, machine-learning model to predict 1-year risk of fall hospitalisation in older adults: a Hong Kong territory-wide cohort and modelling study Open
Objective Older adults face high risk of falls. We developed an electronic-health-record (EHR) based machine-learning (ML) model to predict 1-year risk of fall in older adults for pre-emptive intervention. Methods We included 4 902 161 rec…
View article: <b>DNA Methylation Biomarkers Predict Offspring Metabolic Risk from Mothers with Hyperglycaemia in Pregnancy</b>
<b>DNA Methylation Biomarkers Predict Offspring Metabolic Risk from Mothers with Hyperglycaemia in Pregnancy</b> Open
Gestational diabetes mellitus (GDM) affects almost 18 million pregnancies worldwide, increasing by more than 70% in the last 20 years. DNA methylation has been associated with maternal hyperglycaemia and type 2 diabetes (T2D) risk in offsp…
View article: DNA Methylation Biomarkers Predict Offspring Metabolic Risk From Mothers With Hyperglycemia in Pregnancy
DNA Methylation Biomarkers Predict Offspring Metabolic Risk From Mothers With Hyperglycemia in Pregnancy Open
Gestational diabetes mellitus affects almost 18 million pregnancies worldwide, increasing by >70% in the past 20 years. DNA methylation has been associated with maternal hyperglycemia and type 2 diabetes risk in offspring. This study hy…
View article: <b>DNA Methylation Biomarkers Predict Offspring Metabolic Risk from Mothers with Hyperglycaemia in Pregnancy</b>
<b>DNA Methylation Biomarkers Predict Offspring Metabolic Risk from Mothers with Hyperglycaemia in Pregnancy</b> Open
Gestational diabetes mellitus (GDM) affects almost 18 million pregnancies worldwide, increasing by more than 70% in the last 20 years. DNA methylation has been associated with maternal hyperglycaemia and type 2 diabetes (T2D) risk in offsp…
View article: Author Correction: Chronic kidney disease
Author Correction: Chronic kidney disease Open
View article: A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population
A type 1 diabetes genetic risk score discriminates between type 1 diabetes and type 2 diabetes in a Chinese population Open
Aims/hypothesis We aimed to generate a population-specific type 1 diabetes genetic risk score (GRS) and assess whether it could improve discrimination between type 1 diabetes and type 2 diabetes in a Chinese population. Methods We performe…
View article: The utility of common predictive models for detecting undiagnosed diabetes and prediabetes defined by HbA1c in a Chinese population
The utility of common predictive models for detecting undiagnosed diabetes and prediabetes defined by HbA1c in a Chinese population Open
The community-based program detected high proportion of Chinese adults at high-risk for undiagnosed DM and pre-DM. Utilizing strategies developed by NICE, or other international strategies, can enhance net benefits and potentially improve …
View article: <b>Subc</b><b>lasses of </b><b>glucose trajectories in early childhood stratified </b><b>the </b><b>risk of abnormal glucose tolerance in adolescence and young adulthood</b>
<b>Subc</b><b>lasses of </b><b>glucose trajectories in early childhood stratified </b><b>the </b><b>risk of abnormal glucose tolerance in adolescence and young adulthood</b> Open
Early-life exposures may shape long-term effects on glucose regulation. This study aimed to stratify long-term abnormal glucose tolerance (AGT) risk from early childhood. A total of 906 children were enrolled at baseline and re-evaluated i…
View article: <b>Subc</b><b>lasses of </b><b>glucose trajectories in early childhood stratified </b><b>the </b><b>risk of abnormal glucose tolerance in adolescence and young adulthood</b>
<b>Subc</b><b>lasses of </b><b>glucose trajectories in early childhood stratified </b><b>the </b><b>risk of abnormal glucose tolerance in adolescence and young adulthood</b> Open
Early-life exposures may shape long-term effects on glucose regulation. This study aimed to stratify long-term abnormal glucose tolerance (AGT) risk from early childhood. A total of 906 children were enrolled at baseline and re-evaluated i…
View article: Subclasses of Glucose Trajectories in Early Childhood Stratified the Risk of Abnormal Glucose Tolerance in Adolescence and Young Adulthood
Subclasses of Glucose Trajectories in Early Childhood Stratified the Risk of Abnormal Glucose Tolerance in Adolescence and Young Adulthood Open
Early-life exposures may shape long-term effects on glucose regulation. This study aimed to stratify long-term abnormal glucose tolerance (AGT) risk from early childhood. A total of 906 children were enrolled at baseline and reevaluated in…
View article: Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care
Kidney Disease: Improving Global Outcomes Summit Recommendations on Implementation of Diabetes Management in CKD: From Primary to Data-Driven Collaborative Care Open
View article: Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Preventing chronic kidney disease and maintaining kidney health: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference Open
View article: Association of maternal overweight and gestational diabetes mellitus with offspring adiposity trajectory: from birth to early adolescence
Association of maternal overweight and gestational diabetes mellitus with offspring adiposity trajectory: from birth to early adolescence Open
Aims/hypothesis We aimed to examine offspring adiposity trajectories from birth to age 9–14 years and to assess the joint associations of maternal overweight and gestational diabetes mellitus (GDM) with these trajectories. Methods This is …
View article: Epigenetic age acceleration links atherogenic dyslipidaemia, inflammageing and frailty with adverse cardiovascular outcomes in older adults (UFO): a lipid-metabolome and epigenetic clock analysis
Epigenetic age acceleration links atherogenic dyslipidaemia, inflammageing and frailty with adverse cardiovascular outcomes in older adults (UFO): a lipid-metabolome and epigenetic clock analysis Open
Summary Background Frailty and chronic inflammatory diseases are known risk factors for adverse outcomes and have been associated with epigenetic age acceleration (EAA), a quantitative estimation of biological age based on DNA methylation.…
View article: A microRNA-based dynamic risk score for type 1 diabetes
A microRNA-based dynamic risk score for type 1 diabetes Open
View article: Population-level productivity-adjusted life years lost in individuals with type 2 diabetes in Hong Kong: a life table modelling study
Population-level productivity-adjusted life years lost in individuals with type 2 diabetes in Hong Kong: a life table modelling study Open