J. C. Tonn
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View article: SURG-17. A comprehensive framework for intraoperative mapping and monitoring, and perioperative neurological, linguistic, and outcome assessment in glioma resection: Consensus recommendations from the PIONEER Consortium and RANO resect group
SURG-17. A comprehensive framework for intraoperative mapping and monitoring, and perioperative neurological, linguistic, and outcome assessment in glioma resection: Consensus recommendations from the PIONEER Consortium and RANO resect group Open
BACKGROUND In diffuse glioma patients, greater extent of resection is associated with longer survival. Intraoperative mapping and monitoring are essential to maximize safe resection by identifying and preserving functional areas. Despite w…
View article: P12.60.A PATIENT AGE IS RELATED TO FAVORABLE ASSOCIATION OF SUPRAMAXIMAL RESECTION WITH OUTCOME IN GLIOBLASTOMA - A REPORT OF THE RANO RESECT GROUP
P12.60.A PATIENT AGE IS RELATED TO FAVORABLE ASSOCIATION OF SUPRAMAXIMAL RESECTION WITH OUTCOME IN GLIOBLASTOMA - A REPORT OF THE RANO RESECT GROUP Open
BACKGROUND The oncological role of resection in elderly patients with glioblastoma remains controversial. We evaluated the value of resection in patients ≥65 years with (I) newly diagnosed and (II) recurrent glioblastoma by comparing the p…
View article: OS08.6.A A PROGNOSTIC CLASSIFICATION SYSTEM FOR EXTENT OF RESECTION IN IDH-MUTANT GRADE 2 GLIOMA: A REPORT BY THE RANO RESECT GROUP
OS08.6.A A PROGNOSTIC CLASSIFICATION SYSTEM FOR EXTENT OF RESECTION IN IDH-MUTANT GRADE 2 GLIOMA: A REPORT BY THE RANO RESECT GROUP Open
BACKGROUND The effects of resection in IDH-mutant grade 2 gliomas remain controversial since terminology for extent of resection was inconsistent across trials. We aimed to (I) establish a standardized classification system for extent of r…
View article: P07.10.B INTER-RATER AGREEMENT FROM A MULTI-NATIONAL EXPERT PANEL ON RESECTABILITY OF RECURRENT GLIOBLASTOMA: A COMPLEMENTARY POST-HOC ANALYSIS OF THE PROSPECTIVE, RANDOMIZED DIRECTOR TRIAL
P07.10.B INTER-RATER AGREEMENT FROM A MULTI-NATIONAL EXPERT PANEL ON RESECTABILITY OF RECURRENT GLIOBLASTOMA: A COMPLEMENTARY POST-HOC ANALYSIS OF THE PROSPECTIVE, RANDOMIZED DIRECTOR TRIAL Open
BACKGROUND The role of re-resection in recurrent glioblastoma remains controversial. Associations between higher extents of re-resection and prolonged survival might be explained by the assumption that tumors in less functional (surgically…
View article: Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions Open
Glioblastoma is the most common type of malignant primary brain tumor and a major cause of morbidity and mortality. In 2021, the World Health Organization updated the classification of Central Nervous System (CNS) tumors to restrict gliobl…
View article: Update to the RANO Working Group and EANO recommendations for the clinical use of PET imaging in gliomas
Update to the RANO Working Group and EANO recommendations for the clinical use of PET imaging in gliomas Open
View article: Anatomic Staging of H3 G34-Mutant Diffuse Hemispheric Glioma
Anatomic Staging of H3 G34-Mutant Diffuse Hemispheric Glioma Open
AS is reproducible and prognostically relevant for H3 G34-mutant gliomas, providing insights into tumor spread. It may inform treatment decisions, but larger studies are needed to confirm its clinical utility.
View article: Stereotactically Guided Microsurgical Approach for Deep-Seated Eloquently Located Lesions
Stereotactically Guided Microsurgical Approach for Deep-Seated Eloquently Located Lesions Open
Background/Objectives: Advancements in neuronavigation and intraoperative imaging have made gross-total resection of deep-seated lesions more feasible. However, in eloquently located regions, brain shift can lead to unintentional damage of…
View article: Author Correction: RANO criteria for response assessment of brain metastases based on amino acid PET imaging
Author Correction: RANO criteria for response assessment of brain metastases based on amino acid PET imaging Open
View article: Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions Open
View article: RANO criteria for response assessment of brain metastases based on amino acid PET imaging
RANO criteria for response assessment of brain metastases based on amino acid PET imaging Open
View article: The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant
The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant Open
Background Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 World Health Organization (WHO) classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical…
View article: Temozolomide chemotherapy for patients with newly diagnosed glioblastoma in the CENTRIC EORTC 26071-22072 and CORE trials: Does time of administration matter?
Temozolomide chemotherapy for patients with newly diagnosed glioblastoma in the CENTRIC EORTC 26071-22072 and CORE trials: Does time of administration matter? Open
Background Preclinical work and retrospective studies suggest that temozolomide chemotherapy in glioblastoma may be more effective when administered in the morning rather than the evening. Here we examine the effect of timing in a large co…
View article: Role of hyperconnectivity between tumor and healthy brain in glioblastoma patients
Role of hyperconnectivity between tumor and healthy brain in glioblastoma patients Open
View article: Flip-flop phenomenon on dual SSTR PET and amino acid PET in a case of recurrent meningioma with malignant transformation
Flip-flop phenomenon on dual SSTR PET and amino acid PET in a case of recurrent meningioma with malignant transformation Open
View article: Development and validation of a clinical risk model for postoperative outcome in newly diagnosed glioblastoma: A report of the RANO <i>resect</i> group
Development and validation of a clinical risk model for postoperative outcome in newly diagnosed glioblastoma: A report of the RANO <i>resect</i> group Open
Background Following surgery, patients with newly diagnosed glioblastoma frequently enter clinical trials. Nuanced risk assessment is warranted to reduce imbalances between study arms. Here, we aimed (I) to analyze the interactive effects …
View article: Artificial Intelligence for Response Assessment in Neuro Oncology (AI-RANO), part 1: review of current advancements
Artificial Intelligence for Response Assessment in Neuro Oncology (AI-RANO), part 1: review of current advancements Open
View article: Data from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Data from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Purpose:Current therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to the characterization of the tumor microenvironment, global changes in t…
View article: Figure 3 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Figure 3 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Contralateral TSPO-PET signal elevation is associated with persisting epileptic seizures and worse overall survival. A, Contralateral TSPO-PET shows no quantitative difference between patients presenting with (n = 20) and wit…
View article: Figure 5 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Figure 5 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Contralateral hemispheres of SB28 glioblastoma mice indicate signatures of disease-associated myeloid cells and immunosuppression. A, Volcano plot highlights genes with significant upregulation and downregulation in the contralatera…
View article: Figure 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Figure 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Elevated TSPO-PET signals in the non-lesional hemisphere of patients with glioblastoma. A, Patient selection process. Patients receiving TSPO-PET imaging at initial diagnosis of glioma were allocated. Patients with unilateral manife…
View article: Table 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Table 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Characteristics of the cohort.
View article: Figure 4 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Figure 4 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Back-translation into a glioblastoma mouse model pinpoints myeloid cells as the cellular source of contralateral TSPO-PET signal elevations. A, Glioblastoma mice (n = 15) show higher TSPO-PET signal in the contralateral hemis…
View article: Supplementary Data 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Supplementary Data 1 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Supplementary Figures 1, 2 Supplementary Tables 1 - 3 inlucing Representativeness of Study Participants" supplementary table (Supplementary Table 1)
View article: Figure 2 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Figure 2 from Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Contralateral TSPO-PET signal elevation is associated with tumor phenotype and localization. A and B, Correlation of contralateral TSPO-PET signals in patients with glioblastoma (n = 38) with the TSPO-PET signal of the…
View article: A brave new framework for glioma drug development
A brave new framework for glioma drug development Open
View article: Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome
Remote Neuroinflammation in Newly Diagnosed Glioblastoma Correlates with Unfavorable Clinical Outcome Open
Purpose: Current therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults. In addition to the characterization of the tumor microenvironment, global changes in …
View article: Targeted radionuclide therapy for gliomas: Emerging clinical trial landscape
Targeted radionuclide therapy for gliomas: Emerging clinical trial landscape Open
According to the new WHO classification of 2021, gliomas are a heterogeneous group of tumors with very different histology, molecular genetics, and prognoses. In addition to glioblastomas, the most common gliomas, there are also numerous l…
View article: The biological significance of tumor grade, age, enhancement, and extent of resection in IDH-mutant gliomas: How should they inform treatment decisions in the era of IDH inhibitors?
The biological significance of tumor grade, age, enhancement, and extent of resection in IDH-mutant gliomas: How should they inform treatment decisions in the era of IDH inhibitors? Open
The 2016 and 2021 World Health Organization 2021 Classification of central nervous system tumors have resulted in a major improvement in the classification of isocitrate dehydrogenase (IDH)-mutant gliomas. With more effective treatments ma…
View article: Improved rates of postoperative ischemia, completeness of aneurysm occlusion and neurological deficits in elective clipping of anterior circulation aneurysms over the past 20 years – association with technical improvements
Improved rates of postoperative ischemia, completeness of aneurysm occlusion and neurological deficits in elective clipping of anterior circulation aneurysms over the past 20 years – association with technical improvements Open
Background/Purpose Several periprocedural adjuncts for elective surgical aneurysm treatment have been introduced over the last 20 years to increase safety and efficacy. Besides the introduction of IONM in the late-1990s, ICG-videoangiograp…