Juan A. Rosado
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View article: Notch1 regulates Orai1 and Orai3 expression in breast cancer cells
Notch1 regulates Orai1 and Orai3 expression in breast cancer cells Open
Store-operated Ca²⁺ entry (SOCE) is a major pathway for Ca²⁺ entry that regulates several cellular functions. SOCE remodeling mediated by changes in the expression and/or function of the Orai channels results in the reorganization of intra…
View article: Orai1 plays a critical role in Orai3 synthesis and stability in luminal breast cancer cells
Orai1 plays a critical role in Orai3 synthesis and stability in luminal breast cancer cells Open
Orai family members are the pore-forming subunits of the Ca2+ release-activated Ca2+ (CRAC) channels that mediate store-operated Ca2+ entry (SOCE), a major mechanism for Ca2+ influx controlled by the filling state of the intracellular Ca2+…
View article: Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation
Filamin A C-terminal fragment modulates Orai1 expression by inhibition of protein degradation Open
FLNA cleaving by calpain has been observed in a variety of tumoral, including prostate and colorectal cancer cells, as well as in nontumoral cells, leading to a C-terminal fragment encompassing repeats 16–24. Expression of the FLNA 16–24 f…
View article: Thymoquinone’s Role in Suppressing Platelet-Mediated Migration and Epithelial to Mesenchymal Transition in MDA-MB231 Cells: Mechanistic Involvement of Btk Signaling
Thymoquinone’s Role in Suppressing Platelet-Mediated Migration and Epithelial to Mesenchymal Transition in MDA-MB231 Cells: Mechanistic Involvement of Btk Signaling Open
Nigella sativa seeds, which are also known as black cumin or black seed, contain a bioactive substance called thymoquinone (TQ). It has garnered attention due to its potential health benefits. TQ is a natural substance that has the potenti…
View article: Endogenous Endophthalmitis caused by Abiotrophia/Granulicatella
Endogenous Endophthalmitis caused by Abiotrophia/Granulicatella Open
Purpose To describe a case of endogenous endophthalmitis caused by the bacterium Abiotrophia/Granulicatella adiacens, which clinically appeared consistent with fungal endophthalmitis, in a young patient with a history of intravenous (IV) d…
View article: Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins
Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins Open
Store‐operated Ca 2+ entry is a mechanism controlled by the filling state of the intracellular Ca 2+ stores, predominantly the endoplasmic reticulum (ER), where ER‐resident proteins STIM1 and STIM2 orchestrate the activation of Orai channe…
View article: Extended Synaptotagmins 1 and 2 Are Required for Store-Operated Calcium Entry, Cell Migration and Viability in Breast Cancer Cells
Extended Synaptotagmins 1 and 2 Are Required for Store-Operated Calcium Entry, Cell Migration and Viability in Breast Cancer Cells Open
Extended synaptotagmins (E-Syts) are endoplasmic reticulum (ER)-associated proteins that facilitate the tethering of the ER to the plasma membrane (PM), participating in lipid transfer between the membranes and supporting the Orai1–STIM1 i…
View article: Role of Orai1 and Ca2+-stimulated adenylyl cyclase 8 in the adverse cardiac remodeling after myocardial infarction
Role of Orai1 and Ca2+-stimulated adenylyl cyclase 8 in the adverse cardiac remodeling after myocardial infarction Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Agencia Estatal de Investigación. Background It is well established that abnormalities in the regulation of the intracellular…
View article: The physiological role of TRP channels in sleep and circadian rhythm
The physiological role of TRP channels in sleep and circadian rhythm Open
TRP channels, are non‐specific cationic channels that are involved in multiple physiological processes that include salivation, cellular secretions, memory extinction and consolidation, temperature, pain, store‐operated calcium entry, ther…
View article: Postbiotics of <i>Lacticaseibacillus paracasei</i> <scp>CECT</scp> 9610 and <i>Lactiplantibacillus plantarum</i> <scp>CECT</scp> 9608 attenuates store‐operated calcium entry and <scp>FAK</scp> phosphorylation in colorectal cancer cells
Postbiotics of <i>Lacticaseibacillus paracasei</i> <span>CECT</span> 9610 and <i>Lactiplantibacillus plantarum</i> <span>CECT</span> 9608 attenuates store‐operated calcium entry and <span>FAK</span> phosphorylation in colorectal cancer cells Open
Store‐operated Ca 2+ entry (SOCE) is a major mechanism for Ca 2+ influx in colorectal cancer (CRC) cells. This mechanism, regulated by the filling state of the intracellular Ca 2+ stores, is mediated by the endoplasmic reticulum Ca 2+ sens…
View article: Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins
Feedback modulation of Orai1α and Orai1β protein content mediated by STIM proteins Open
Store-operated Ca 2+ entry (SOCE) is a mechanism controlled by the filling state of the intracellular Ca 2+ stores, predominantly the endoplasmic reticulum (ER), where ER-resident proteins STIM1 and STIM2 orchestrate the activation of Orai…
View article: Reduced Ca<sup>2+</sup> mobilization in neonatal human platelets involves SARAF and pannexin‐1
Reduced Ca<sup>2+</sup> mobilization in neonatal human platelets involves SARAF and pannexin‐1 Open
Platelets from neonates have been shown to exhibit a reduced response to physiological agonists, such as thrombin; however, the mechanism behind these findings is poorly understood. Berna‐Erro et al. now provide differences in SARAF and pa…
View article: Thrombotic Alterations under Perinatal Hypoxic Conditions: HIF and Other Hypoxic Markers
Thrombotic Alterations under Perinatal Hypoxic Conditions: HIF and Other Hypoxic Markers Open
Hypoxia is considered to be a stressful physiological condition, which may occur during labor and the later stages of pregnancy as a result of, among other reasons, an aged placenta. Therefore, when gestation or labor is prolonged, low oxy…
View article: The Ca2+ Sensor STIM in Human Diseases
The Ca2+ Sensor STIM in Human Diseases Open
The STIM family of proteins plays a crucial role in a plethora of cellular functions through the regulation of store-operated Ca2+ entry (SOCE) and, thus, intracellular calcium homeostasis. The two members of the mammalian STIM family, STI…
View article: New Insights into the Reparative Angiogenesis after Myocardial Infarction
New Insights into the Reparative Angiogenesis after Myocardial Infarction Open
Myocardial infarction (MI) causes massive loss of cardiac myocytes and injury to the coronary microcirculation, overwhelming the limited capacity of cardiac regeneration. Cardiac repair after MI is finely organized by complex series of pro…
View article: Secretion of Interleukin 6 in Human Skeletal Muscle Cultures Depends on Ca2+ Signalling
Secretion of Interleukin 6 in Human Skeletal Muscle Cultures Depends on Ca2+ Signalling Open
The systemic effects of physical activity are mediated by the release of IL-6 and other myokines from contracting muscle. Although the release of IL-6 from muscle has been extensively studied, the information on the cellular mechanisms is …
View article: Functional differences in agonist‐induced plasma membrane expression of Orai1α and Orai1β
Functional differences in agonist‐induced plasma membrane expression of Orai1α and Orai1β Open
Orai1 is the pore‐forming subunit of the store‐operated Ca 2+ release‐activated Ca 2+ (CRAC) channels involved in a variety of cellular functions. Two Orai1 variants have been identified, the long form, Orai1α, containing 301 amino acids, …
View article: Supplementary Table S2 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Supplementary Table S2 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
Key resources Table
View article: Figures S1-S4 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Figures S1-S4 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
PCs expression in T cells and effect of PC inhibition on PD-1 expression, T cell signaling, survival and cytotoxicity.
View article: Supplementary Table S1 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Supplementary Table S1 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
Primer sequences
View article: Data from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Data from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
Proprotein convertases (PC) activate precursor proteins that play crucial roles in various cancers. In this study, we investigated whether PC enzyme activity is required for expression of the checkpoint protein programmed cell death protei…
View article: Supplementary Materials and Methods from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Supplementary Materials and Methods from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
Detailed description of the methodology performed.
View article: Data from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Data from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
Proprotein convertases (PC) activate precursor proteins that play crucial roles in various cancers. In this study, we investigated whether PC enzyme activity is required for expression of the checkpoint protein programmed cell death protei…
View article: Supplementary Table S1 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Supplementary Table S1 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
Primer sequences
View article: Supplementary Table S2 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Supplementary Table S2 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
Key resources Table
View article: Figures S1-S4 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer
Figures S1-S4 from Inactivation of Proprotein Convertases in T Cells Inhibits PD-1 Expression and Creates a Favorable Immune Microenvironment in Colorectal Cancer Open
PCs expression in T cells and effect of PC inhibition on PD-1 expression, T cell signaling, survival and cytotoxicity.