David J. Cohen
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View article: Author Correction: Exome analysis links kidney malformations to developmental disorders and reveals causal genes
Author Correction: Exome analysis links kidney malformations to developmental disorders and reveals causal genes Open
View article: Assessing The Bethesda System for Reporting Thyroid Cytopathology (TBS) Data as a Quality Indicator from a Tertiary Care Institution
Assessing The Bethesda System for Reporting Thyroid Cytopathology (TBS) Data as a Quality Indicator from a Tertiary Care Institution Open
View article: Contemporary Resource Use and Costs Among Patients With Medically Managed Severe Aortic Stenosis: Results From a US National Claims Database
Contemporary Resource Use and Costs Among Patients With Medically Managed Severe Aortic Stenosis: Results From a US National Claims Database Open
Background Patients with severe aortic stenosis (AS) who are managed medically have a poor prognosis. No contemporary studies have examined resource use and costs associated with medical management for severe AS. Methods Using the Optum Ma…
View article: Short-Term Outcomes of Impella-Supported High-Risk Percutaneous Coronary Intervention in Surgically Ineligible Patients: Insights From PROTECT III
Short-Term Outcomes of Impella-Supported High-Risk Percutaneous Coronary Intervention in Surgically Ineligible Patients: Insights From PROTECT III Open
View article: Incremental Cost and Length of Stay Associated With Complications of Transcatheter Aortic Valve Replacement
Incremental Cost and Length of Stay Associated With Complications of Transcatheter Aortic Valve Replacement Open
In contemporary practice, approximately one in 3 Medicare TAVR patients experience serious complications, substantially increasing hospital resource use. Despite improvements in TAVR outcomes and efficiency, additional cost savings can be …
View article: Lessons Learned From the ACURATE IDE Trial for Transcatheter Aortic Valve Replacement
Lessons Learned From the ACURATE IDE Trial for Transcatheter Aortic Valve Replacement Open
The recent voluntary withdrawal of the ACURATE neo2 transcatheter aortic valve replacement device by Boston Scientific offers a compelling case study in the complex interplay of device design, clinical evidence, regulatory requirements, an…
View article: Exome analysis links kidney malformations to developmental disorders and reveals causal genes
Exome analysis links kidney malformations to developmental disorders and reveals causal genes Open
View article: Sex Differences in Stroke Frequency and Severity Following Transcatheter Aortic Valve Replacement
Sex Differences in Stroke Frequency and Severity Following Transcatheter Aortic Valve Replacement Open
Background Stroke is a recognized complication following transcatheter aortic valve replacement (TAVR). Although women have historically had a higher rate of bleeding and vascular complications after TAVR, contemporary data on sex differen…
View article: Cochlear Implantation in MELAS Syndrome: Audiological Outcomes, Surgical Considerations, and Clinical Implications
Cochlear Implantation in MELAS Syndrome: Audiological Outcomes, Surgical Considerations, and Clinical Implications Open
View article: Outcomes After Transcatheter Aortic Valve Replacement Among Medicare Beneficiaries: The Impact of Frailty and Social Vulnerability
Outcomes After Transcatheter Aortic Valve Replacement Among Medicare Beneficiaries: The Impact of Frailty and Social Vulnerability Open
View article: 71852 | Impact of Periprocedural Adverse Events on Costs and Length of Stay Following Transcatheter Tricuspid Valve Replacement
71852 | Impact of Periprocedural Adverse Events on Costs and Length of Stay Following Transcatheter Tricuspid Valve Replacement Open
View article: 71201 | Hospital Performance on 30-Day Readmissions After Transcatheter Aortic Valve Replacement: A Report From the STS/ACC TVT Registry
71201 | Hospital Performance on 30-Day Readmissions After Transcatheter Aortic Valve Replacement: A Report From the STS/ACC TVT Registry Open
View article: Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study
Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study Open
Background Percutaneous left ventricular assist devices are used prophylactically to prevent hypotension during high‐risk percutaneous coronary intervention. However, the impact of preprocedural hemodynamic profiles on procedural and clini…
View article: Trends and Physician-Level Variation in Contrast Volume During Percutaneous Coronary Intervention
Trends and Physician-Level Variation in Contrast Volume During Percutaneous Coronary Intervention Open
View article: Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery
Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery Open
Background and Aims Mitral valve prolapse (MVP) is associated with progressive mitral regurgitation (MR) requiring surgical correction. A subset of patients with MVP experience ventricular arrhythmias (VA), and mitral annular disjunction (…
View article: XALOC-1
XALOC-1 Open
Our results indicate that clinical remission is a realistic goal, sustainable up to 2 years in around one-third of patients with SEA receiving benralizumab. In this study, remission was more likely in patients with lower baseline disease b…
View article: Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial
Cardiac Biomarkers in Patients With Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial Open
BACKGROUND: The EARLY TAVR trial (Evaluation of TAVR Compared to Surveillance for Patients With Asymptomatic Severe Aortic Stenosis) demonstrated that early transcatheter aortic valve replacement (TAVR) intervention was superior to clinica…
View article: Real-World Clinical Outcomes and Health Care Utilization in Patients With Severe Tricuspid Regurgitation
Real-World Clinical Outcomes and Health Care Utilization in Patients With Severe Tricuspid Regurgitation Open
Over 3 years of follow-up, patients with severe TR had high rates of death and adverse clinical events and incurred substantial health care costs. Longer-term data regarding the impact of transcatheter interventions for severe TR on clinic…
View article: Cochlear Implantation in Down Syndrome: A Systematic Review of Indications, Challenges, and Long-Term Outcomes
Cochlear Implantation in Down Syndrome: A Systematic Review of Indications, Challenges, and Long-Term Outcomes Open
View article: The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting
The reversibility of cardiac damage after transcatheter aortic valve implantation and short-term outcomes in a real-world setting Open
Aims This study aims to assess the changes in cardiac damage stage in a real-world cohort of patients undergoing transcatheter aortic valve implantation (TAVI), and to investigate the prognostic value of cardiac damage stage evolution. Met…
View article: Contemporary Administrative Codes to Identify Pulmonary Vein Isolation Procedures for Atrial Fibrillation
Contemporary Administrative Codes to Identify Pulmonary Vein Isolation Procedures for Atrial Fibrillation Open
Background Use of pulmonary vein isolation (PVI) to treat atrial fibrillation continues to increase. Despite great interest in leveraging administrative data for real‐world analyses, contemporary procedural codes for identifying PVI have n…
View article: Two approaches to mass closure analysis for carbon-rich aerosol in Metro Manila, Philippines
Two approaches to mass closure analysis for carbon-rich aerosol in Metro Manila, Philippines Open
We characterized PM in Metro Manila, highlighting high contribution of carbonaceous species and ultrafine particles, and achieved mass closure.
View article: Use of Claims to Assess Outcomes and Treatment Effects in the Evolut Low Risk Trial
Use of Claims to Assess Outcomes and Treatment Effects in the Evolut Low Risk Trial Open
BACKGROUND: Food and Drug Administration–mandated postmarket studies for transcatheter aortic valve replacement in low-risk populations plan to use passively collected registry data linked to claims for long-term follow-up out to 10 years.…
View article: Contribution margins and utilization of transcatheter aortic valve replacement versus surgical aortic valve replacement in the Medicare population
Contribution margins and utilization of transcatheter aortic valve replacement versus surgical aortic valve replacement in the Medicare population Open
Most hospitals had positive CMs for TAVR and nearly all had positive CMs for SAVR. Positive CMs for TAVR for individual hospitals were associated with a significant increase in the utilization of TAVR. However, the magnitude of difference …
View article: Exome-wide analysis of congenital kidney anomalies reveals new genes and shared architecture with developmental disorders
Exome-wide analysis of congenital kidney anomalies reveals new genes and shared architecture with developmental disorders Open
Kidney anomalies (KA) are developmental disorders that commonly cause pediatric chronic kidney disease and mortality. We examined rare coding variants in 248 KA trios and 1,742 singleton KA cases and compared them to 22,258 controls. Diagn…
View article: Acute Valve Syndrome in Aortic Stenosis
Acute Valve Syndrome in Aortic Stenosis Open
View article: Long-Term Clinical Outcomes Following the WATCHMAN Device Use in Medicare Beneficiaries
Long-Term Clinical Outcomes Following the WATCHMAN Device Use in Medicare Beneficiaries Open
BACKGROUND: Long-term outcomes following left atrial appendage occlusion outside clinical trials and small registries are largely unknown. Collecting these data was a condition of US market authorization of the WATCHMAN device. The aim of …
View article: Clinical outcomes among patients with mitral valve regurgitation undergoing Impella-supported high-risk PCI
Clinical outcomes among patients with mitral valve regurgitation undergoing Impella-supported high-risk PCI Open
Trial Name: The Global cVAD Study (cVAD) ClinicalTrial.govIdentifier:NCT04136392 URL: https://clinicaltrials.gov/ct2/show/NCT04136392?term=cvad&draw=2&rank=2.
View article: Trends in Complications Among Patients Undergoing Aortic Valve Replacement in the United States
Trends in Complications Among Patients Undergoing Aortic Valve Replacement in the United States Open
Background The treatment of severe aortic stenosis has evolved considerably since the introduction of transcatheter aortic valve replacement (TAVR), yet trends in complications for patients undergoing TAVR or surgical aortic valve replacem…
View article: Burden of Heart Failure in Patients With Tricuspid Regurgitation and Effect of Transcatheter Repair on Different Subdimensions of Quality of Life
Burden of Heart Failure in Patients With Tricuspid Regurgitation and Effect of Transcatheter Repair on Different Subdimensions of Quality of Life Open
Background Right‐sided heart failure (HF) due to severe tricuspid regurgitation (TR) is associated with reduced quality of life (QoL). Here, we analyzed the impact of TR on specific QoL dimensions and the effect of transcatheter tricuspid …