Martin Corsten
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View article: Shared Decision-Making During Surgical Consultations for Indeterminate Thyroid Nodules
Shared Decision-Making During Surgical Consultations for Indeterminate Thyroid Nodules Open
Importance Several feasible management options exist for indeterminate thyroid nodules (ITNs), which can lead to decisional conflict (DC) and uncertainty in patients. Objective To investigate patient and physician participation in shared d…
View article: Needs Assessment for a Decision Aid in Oral Cancer Requiring Major Resection and Reconstructions
Needs Assessment for a Decision Aid in Oral Cancer Requiring Major Resection and Reconstructions Open
Objective Treatment of advanced oral cavity cancer necessitates ablative and reconstructive surgery that can be life‐altering, creating nuanced priorities between the desire for survival and quality of life. This study sought to describe c…
View article: Oncologic and Functional Outcomes of T3 Glottic Squamous Cell Carcinoma Following Transoral Laser Microsurgery: A Retrospective Chart Review
Oncologic and Functional Outcomes of T3 Glottic Squamous Cell Carcinoma Following Transoral Laser Microsurgery: A Retrospective Chart Review Open
Importance Few centers globally use transoral laser microsurgery (TLM) for primary treatment of T3 glottic squamous cell carcinoma (SCC); consequently, data on its use in this setting are sparse. Objective The aim of this study was to eval…
View article: “Close Then Clear” Margins in Transoral Resection of p16+ Oropharyngeal Squamous Cell Carcinoma
“Close Then Clear” Margins in Transoral Resection of p16+ Oropharyngeal Squamous Cell Carcinoma Open
Objective Standard 5‐mm surgical margins in the oropharynx are challenging due to the intimate relationship with neurovascular structures and patient function. De‐escalation of therapy with the acceptance of close surgical margins may impr…
View article: Outcomes Following Transoral Laser Microsurgery for T1b and T2a Glottic Squamous Cell Carcinoma With and Without Anterior Commissure Involvement: A Retrospective Chart Review
Outcomes Following Transoral Laser Microsurgery for T1b and T2a Glottic Squamous Cell Carcinoma With and Without Anterior Commissure Involvement: A Retrospective Chart Review Open
Importance There is a limited understanding of anterior commissure (AC) involvement in glottic squamous cell carcinoma (SCC), particularly when comparing T1b, T2a with AC involvement (T2AC), and T2a without AC involvement (T2noAC). Objecti…
View article: Management of positive resection margins following transoral laser microsurgery for glottic cancer
Management of positive resection margins following transoral laser microsurgery for glottic cancer Open
Objectives The current literature provides limited guidance on the management of positive margins (PMs) following transoral laser microsurgery (TLM) for glottic squamous cell carcinoma (SCC). Long‐term data exploring the treatment of PMs w…
View article: Survival of Patients With Head and Neck Merkel Cell Cancer
Survival of Patients With Head and Neck Merkel Cell Cancer Open
Importance Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. Due to its relatively low incidence and limited prospective trials, current recommendations are guided by historical single-institution retrospecti…
View article: Socioeconomic Status Among Cochlear Implant Candidates and Association With Surgical Pursuance
Socioeconomic Status Among Cochlear Implant Candidates and Association With Surgical Pursuance Open
Importance Despite the sizeable global burden of hearing loss, cochlear implants have poor penetrance among eligible hearing-impaired individuals. Identifying populations who may benefit from a cochlear implant but among whom penetrance is…
View article: Comparison of socio-economic determinants of COVID-19 testing and positivity in Canada: A multi-provincial analysis
Comparison of socio-economic determinants of COVID-19 testing and positivity in Canada: A multi-provincial analysis Open
Background The effects of the COVID-19 pandemic have been more pronounced for socially disadvantaged populations. We sought to determine how access to SARS-CoV-2 testing and the likelihood of testing positive for COVID-19 were associated w…
View article: The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck
The impact of national holidays on postoperative radiotherapy of squamous cell carcinoma of the head and neck Open
Our findings were consistent with previously published studies in limiting the interval between surgery and PORT. We identified the novel finding of paired holidays as a significant predictor in determining LR, suggesting the importance of…
View article: A case report: Primary malignant melanoma of the glottic larynx – A very rare entity
A case report: Primary malignant melanoma of the glottic larynx – A very rare entity Open
Background: Primary mucosal melanoma of the larynx is an extremely rare entity. Our case represents the seventeenth case reported to date globally, and the first Canadian case to be reported. Case presentation: We present the case of a 70-…
View article: Supplemental Table 2 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Supplemental Table 2 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Table of monensin induced genes in SCC25 cells identified by RNAseq analysis.
View article: Supplemental Table 3 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Supplemental Table 3 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Table of the patient characteristics of the ex-vivo tissue samples evaluated in this study.
View article: Data from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Data from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Targeting the EGFR, with inhibitors such as erlotinib, represents a promising therapeutic option in advanced head and neck squamous cell carcinomas (HNSCC). However, they lack significant efficacy as single agents. Recently, we identified …
View article: Data from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Data from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Targeting the EGFR, with inhibitors such as erlotinib, represents a promising therapeutic option in advanced head and neck squamous cell carcinomas (HNSCC). However, they lack significant efficacy as single agents. Recently, we identified …
View article: Supplemental Table 3 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Supplemental Table 3 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Table of the patient characteristics of the ex-vivo tissue samples evaluated in this study.
View article: Supplemental Table 2 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Supplemental Table 2 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Table of monensin induced genes in SCC25 cells identified by RNAseq analysis.
View article: Supplemental Table 1 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Supplemental Table 1 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Table of agents that enhance either lovastatin or erlotinib cytotoxicity in HNSCC cells identified by screening a 1200 FDA approved compound library.
View article: Supplemental Table 1 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors
Supplemental Table 1 from Monensin Inhibits Epidermal Growth Factor Receptor Trafficking and Activation: Synergistic Cytotoxicity in Combination with EGFR Inhibitors Open
Table of agents that enhance either lovastatin or erlotinib cytotoxicity in HNSCC cells identified by screening a 1200 FDA approved compound library.
View article: Frequency and accuracy of intraoperative bone margin sampling for T4a cancers of the head and neck at the QEII Health Sciences Centre: A retrospective chart review
Frequency and accuracy of intraoperative bone margin sampling for T4a cancers of the head and neck at the QEII Health Sciences Centre: A retrospective chart review Open
Background Stage T4a cancers are associated with a 5-year survival of 21.6–59.0%. Adequate resection of these tumors is a critical factor in maximizing survival. Tumors invading bone pose a unique challenge to intraoperative bone margin as…
View article: Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study
Salivary testing for SARS-CoV-2 in the pediatric population: a diagnostic accuracy study Open
Salivary testing for SARS-CoV-2 in the pediatric population is less invasive and shows similar detection of SARS-CoV-2 to nasopharyngeal swabs. It may therefore provide a feasible alternative for diagnosis of SARS-CoV-2 infection in childr…
View article: Evaluating the Rising Incidence of Thyroid Cancer and Thyroid Nodule Detection Modes
Evaluating the Rising Incidence of Thyroid Cancer and Thyroid Nodule Detection Modes Open
This retrospective analysis found that most thyroid cancers were discovered in patients who had no thyroid-referable symptoms; on average, these cancers were smaller than symptomatic thyroid cancers. Still, some asymptomatic cancers were l…
View article: Margin Sampling and Survival Outcomes in Oral Cavity and p16‐Positive Oropharyngeal Squamous Cell Carcinoma
Margin Sampling and Survival Outcomes in Oral Cavity and p16‐Positive Oropharyngeal Squamous Cell Carcinoma Open
Objective To compare the association of margin sampling technique on survival outcomes in surgically treated cT1‐2 oral cavity and oropharyngeal squamous cell carcinoma. Study Design A prospective longitudinal cohort study. Setting Tertiar…
View article: Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: A randomized controlled trial
Injection laryngoplasty during transoral laser microsurgery for early glottic cancer: A randomized controlled trial Open
Background Transoral laser microsurgery is widely used for treating T1/T2 glottic cancers. Hyaluronic acid (HA) is commonly used in vocal cord augmentation. We investigated the impact of intra-operative injection laryngoplasty on voice out…
View article: Oncological and functional outcomes following treatment of T1a glottic squamous cell carcinoma with transoral laser microsurgery
Oncological and functional outcomes following treatment of T1a glottic squamous cell carcinoma with transoral laser microsurgery Open
Background Laryngeal cancers of glottic origin comprise a large proportion of head and neck malignancies. Transoral laser microsurgery (TLM) and radiation therapy are mainstays in the treatment of early stage glottic cancer, but debate per…
View article: Management of Peritonsillar Abscesses in Adults: Survey of Otolaryngologists in Canada and the United States
Management of Peritonsillar Abscesses in Adults: Survey of Otolaryngologists in Canada and the United States Open
Objective The management of peritonsillar abscess (PTA) has evolved over time. We sought to define contemporary practice patterns for the diagnosis and treatment of PTA. Study Design Cross‐sectional survey. Setting The 15‐question survey w…
View article: Functional and Oncologic Outcomes of Octogenarians Undergoing Transoral Laser Microsurgery for Laryngeal Cancer
Functional and Oncologic Outcomes of Octogenarians Undergoing Transoral Laser Microsurgery for Laryngeal Cancer Open
Objective To evaluate the oncologic and functional outcomes of transoral laser microsurgery (TLM) for glottic cancers in patients ≥80 years. Study Design Prospectively collected case series. Setting QEII Health Sciences Centre, Halifax, Ca…
View article: A Protocol for a Pan-Canadian Prospective Observational Study on Active Surveillance or Surgery for Very Low Risk Papillary Thyroid Cancer
A Protocol for a Pan-Canadian Prospective Observational Study on Active Surveillance or Surgery for Very Low Risk Papillary Thyroid Cancer Open
Background The traditional management of papillary thyroid cancer (PTC) is thyroidectomy (total or partial removal of the thyroid). Active surveillance (AS) may be considered as an alternative option for small, low risk PTC. AS involves cl…
View article: Psychosocial Distress in Adult Patients Awaiting Cancer Surgery during the COVID-19 Pandemic
Psychosocial Distress in Adult Patients Awaiting Cancer Surgery during the COVID-19 Pandemic Open
Cancer causes substantial emotional and psychosocial distress, which may be exacerbated by delays in treatment. The COVID-19 pandemic has resulted in increased wait times for many patients with cancer. In this study, the psychosocial distr…