Melanie J. Davies
YOU?
Author Swipe
View article: Cardiorenal outcomes of weight loss interventions in people with CKD and type 2 diabetes
Cardiorenal outcomes of weight loss interventions in people with CKD and type 2 diabetes Open
Background and Hypothesis In patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD), there remains a paucity of data from large high-quality real-world studies on the efficacy of weight-lowering interventions, inclu…
View article: The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study
The Effect of Increased Sodium Intake with a Carbohydrate-Rich Meal on Glucose Homeostasis in People without Diabetes after Roux-en-Y Gastric Bypass: a Proof-of-Concept, Randomized, Open-Label, Crossover Study Open
Introduction Roux-en-Y gastric bypass (RYGB) induces substantial weight loss and changes in glucose homeostasis, partly through alterations in gastrointestinal anatomy and nutrient absorption. Sodium-glucose co-transporters-1 (SGLT-1) faci…
View article: Effects of semaglutide in obesity‐related heart failure with preserved ejection fraction across the age spectrum: Findings from the <scp>STEP</scp> ‐ <scp>HFpEF</scp> programme
Effects of semaglutide in obesity‐related heart failure with preserved ejection fraction across the age spectrum: Findings from the <span>STEP</span> ‐ <span>HFpEF</span> programme Open
Background The prevalence of heart failure with preserved ejection fraction (HFpEF) increases with age, and older adults with HFpEF have worse physical function, quality of life, and clinical outcomes. Semaglutide demonstrated efficacy in …
View article: Real-World Effectiveness of Insulin Glargine 300 U/ml in People with Type 2 Diabetes Previously Treated with Tirzepatide: The DELIVER-T Study
Real-World Effectiveness of Insulin Glargine 300 U/ml in People with Type 2 Diabetes Previously Treated with Tirzepatide: The DELIVER-T Study Open
In insulin-naïve people with T2D who had suboptimal HbA1c with tirzepatide, significant reductions in HbA1c and improvements in the percentage of people reaching HbA1c target of < 7.0% were observed with Gla-300. Infographic and video abst…
View article: Trajectories of type 2 diabetes and cancer in 330 000 individuals with prediabetes: 20-year observational study in England
Trajectories of type 2 diabetes and cancer in 330 000 individuals with prediabetes: 20-year observational study in England Open
National Institute for Health and Care Research (NIHR) Applied Research Collaboration, East Midlands, NIHR Leicester British Retail Consortium, Hope Against Cancer.
View article: Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network
Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network Open
The five-year risk of cancer was higher in those with newly diagnosed type 2 diabetes versus those without. Absolute risk was greater in middle-older age adults, although relative rates were greater amongst younger adults. This persisted a…
View article: The acceptability of virtual diabetes self-management education and support (DSMES) in type 2 diabetes: An explorative qualitative study
The acceptability of virtual diabetes self-management education and support (DSMES) in type 2 diabetes: An explorative qualitative study Open
With a strong infrastructure, virtual DSMES programmes can be offered effectively in various formats (in-person and virtually), offering inclusive and tailored education format and individual choice.
View article: Proteomics insights: exploring the inflammatory and metabolic signatures of ethnicity and change in physical activity in non-diabetic hyperglycaemia
Proteomics insights: exploring the inflammatory and metabolic signatures of ethnicity and change in physical activity in non-diabetic hyperglycaemia Open
NIHR Leicester Biomedical Research Centre.
View article: Physical Function Outcomes in People with Type 2 Diabetes: What is the Impact of Type 2 Diabetes Duration Above and Beyond Chronological Age?
Physical Function Outcomes in People with Type 2 Diabetes: What is the Impact of Type 2 Diabetes Duration Above and Beyond Chronological Age? Open
View article: Structured group education programme and accompanying mHealth intervention to promote physical activity in women with a history of gestational diabetes ( <i>Baby Steps</i> ): 4‐year follow‐up of a randomised controlled trial
Structured group education programme and accompanying mHealth intervention to promote physical activity in women with a history of gestational diabetes ( <i>Baby Steps</i> ): 4‐year follow‐up of a randomised controlled trial Open
View article: Comparison of the effectiveness of fast-acting insulin aspart with rapid-acting insulin analogues on glycaemic control: a retrospective cohort study using patient data from primary care practices in England
Comparison of the effectiveness of fast-acting insulin aspart with rapid-acting insulin analogues on glycaemic control: a retrospective cohort study using patient data from primary care practices in England Open
Objectives This study compared the effectiveness of first-time use of faster aspart with rapid-acting insulin analogues in patients with type 1 diabetes (T1D) or type 2 diabetes (T2D). Design, setting This retrospective cohort study used d…
View article: Cardiovascular MRI Feature-Tracking Strain Rate for Assessment of Diastolic Function
Cardiovascular MRI Feature-Tracking Strain Rate for Assessment of Diastolic Function Open
A distinctive pattern of cardiac MRI feature-tracking left ventricular early and late diastolic strain rates was observed across the range of diastolic dysfunction severity.
View article: Experience with insulin detemir for type 2 diabetes in older people and people with comorbidities
Experience with insulin detemir for type 2 diabetes in older people and people with comorbidities Open
Detemir appears to be an effective and well-tolerated treatment for T2D in older people, and those with CVD, renal disease or liver disease.
View article: Interrelationship Between Cardiopulmonary Exercise Testing Indices and Markers of Subclinical Cardiovascular Dysfunction in Those with Type 2 Diabetes—An Observational Cross-Sectional Analysis
Interrelationship Between Cardiopulmonary Exercise Testing Indices and Markers of Subclinical Cardiovascular Dysfunction in Those with Type 2 Diabetes—An Observational Cross-Sectional Analysis Open
Purpose: While peak oxygen uptake (V.O2peak) is the gold standard method for assessing exercise tolerance, there is a tendency for underestimation. Several other cardiopulmonary exercise testing (CPET) variables may provide additive progno…
View article: Frailty and Effects of Semaglutide in Obesity-Related HFpEF
Frailty and Effects of Semaglutide in Obesity-Related HFpEF Open
Semaglutide resulted in a similar reduction in BW across frailty subgroups but greater improvements in HF-related symptoms. Moreover, semaglutide reduced frailty burden after 52 weeks of treatment. (Research Study to Investigate How Well S…
View article: Weight loss interventions and obesity‐associated cancers in people with type 2 diabetes and overweight/obesity: A real‐world observational study
Weight loss interventions and obesity‐associated cancers in people with type 2 diabetes and overweight/obesity: A real‐world observational study Open
Aims To evaluate whether weight‐loss interventions are associated with obesity‐associated cancers (OAC) in individuals with overweight/obesity and type 2 diabetes (T2D). Materials and Methods This retrospective cohort study utilised the Tr…
View article: Management of Early-Onset Type 2 Diabetes in Adults: Current Evidence and Future Directions
Management of Early-Onset Type 2 Diabetes in Adults: Current Evidence and Future Directions Open
The global prevalence of early-onset type 2 diabetes (EOT2D) is rising rapidly. Adults with EOT2D represent a high-risk population characterised by increased rates of microvascular and macrovascular complications, adverse psychological wel…
View article: 5-027 Liver fat reduction is associated with favourable haemodynamic changes in adults with obesity and type 2 diabetes: a secondary analysis of the DIASTOLIC randomised controlled trial
5-027 Liver fat reduction is associated with favourable haemodynamic changes in adults with obesity and type 2 diabetes: a secondary analysis of the DIASTOLIC randomised controlled trial Open
View article: Diabetes Foot Ulcer Prevention: A Review of Footwear Width Assessment for At‐Risk Feet
Diabetes Foot Ulcer Prevention: A Review of Footwear Width Assessment for At‐Risk Feet Open
Background Diabetes‐related foot ulceration (DFU) is often related to footwear fit. People with diabetes often have wider feet than in those without diabetes. Standards for evaluating footwear width in those at risk are therefore important…
View article: Intensity modifies the association between continuous bouts of physical activity and risk of mortality: A prospective UK Biobank cohort analysis
Intensity modifies the association between continuous bouts of physical activity and risk of mortality: A prospective UK Biobank cohort analysis Open
Optimal PA patterns for reducing mortality differ by intensity and duration. For moderate-intensity PA, a lower mortality risk may be optimized by prioritizing continuous PA for up to 20 min. However, for vigorous-intensity PA, multiple sh…
View article: The retina as a window into detecting subclinical cardiovascular disease in type 2 diabetes
The retina as a window into detecting subclinical cardiovascular disease in type 2 diabetes Open
View article: Foot Measurements From Three‐Dimensional Scans: Elinvision 3DST Reliability
Foot Measurements From Three‐Dimensional Scans: Elinvision 3DST Reliability Open
Background 3D foot scanners such as the Elinvision 3DST foot scanner potentially offer a faster, alternative method to traditional plaster casting to produce orthotics or therapeutic footwear. Objective(s) To assess the reliability of 3DST…
View article: Triple Agonism Based Therapies for Obesity
Triple Agonism Based Therapies for Obesity Open
Purpose of the Review Glucagon-like peptide 1 (GLP-1) receptor agonists (RA) have transformed obesity and type 2 diabetes (T2D) management. Tirzepatide, the first dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) RA approved fo…
View article: Proteomic signatures reflect effects of semaglutide treatment for MASH
Proteomic signatures reflect effects of semaglutide treatment for MASH Open
Liver biopsy is the current gold standard for the diagnosis of metabolic dysfunction-associated steatohepatitis (MASH); however, this procedure is invasive and time consuming for patients living with MASH. The use of non-invasive tests to …
View article: Type 2 diabetes risk communication following a diagnosis of gestational diabetes mellitus: A qualitative study
Type 2 diabetes risk communication following a diagnosis of gestational diabetes mellitus: A qualitative study Open
Background Gestational diabetes mellitus (GDM) increases women's risk of developing type 2 diabetes (T2DM) tenfold. Understanding of T2DM risk in women with GDM is variable and can impact health behaviours. To better understand how T2DM ri…
View article: Risk factors for development of diabetic foot ulcer disease in two large contemporary <scp>UK</scp> cohorts
Risk factors for development of diabetic foot ulcer disease in two large contemporary <span>UK</span> cohorts Open
Aims Diabetic foot ulcer disease ( DFUD ) is common, life‐changing and associated with a lower 5‐Year survival rate than many cancers. However, the risk factors for DFUD have generally been identified in small, single‐centre, clinic‐based …
View article: Use, Usability, and Experience Testing of a Digital Health Intervention to Support Chronic Kidney Disease Self-Management: Mixed Methods Study.
Use, Usability, and Experience Testing of a Digital Health Intervention to Support Chronic Kidney Disease Self-Management: Mixed Methods Study. Open
The MK&M DHI was well-received and used by the participants. Our findings show that a wide range of people with CKD, including older adults, are capable and willing to use DHIs for kidney health. Identification of real-life use and usabili…
View article: Outcomes of Different Lifestyle Approaches in a Multicentre, Open-Label, Parallel-Group, Randomised Controlled Trial of the Effectiveness of Integrating a Pragmatic Pathway for Prescribing Liraglutide 3.0 mg in Weight Management Services (STRIVE Study)
Outcomes of Different Lifestyle Approaches in a Multicentre, Open-Label, Parallel-Group, Randomised Controlled Trial of the Effectiveness of Integrating a Pragmatic Pathway for Prescribing Liraglutide 3.0 mg in Weight Management Services (STRIVE Study) Open
Background/Objectives: The STRIVE study was a multicentre, open-label, real-world clinical trial evaluating the effectiveness of a targeted prescribing pathway for liraglutide 3.0 mg as an adjunct to standard care versus standard care alon…
View article: The use of <scp>SGLT2</scp> inhibitors in people with diabetes‐related foot disease: A Delphi‐based consensus study
The use of <span>SGLT2</span> inhibitors in people with diabetes‐related foot disease: A Delphi‐based consensus study Open
Aims To generate expert consensus‐based clinical recommendations on the use of SGLT2 inhibitors in those with diabetes and diabetes‐related foot disease (DFD). Materials and Methods This study employed a two‐round online Delphi technique. …
View article: Exploring the disconnect: mechanisms underpinning the absence of physical function improvement with SGLT2 inhibitors
Exploring the disconnect: mechanisms underpinning the absence of physical function improvement with SGLT2 inhibitors Open
Current evidence suggests sodium-glucose cotransporter 2 inhibitors (SGLT2i) do not consistently improve patient physical function, despite improvements in clinical symptoms and reductions in both adiposity and body weight. We highlight he…