Jean Davignon
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View article: WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects
WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects Open
Reduced white adipose tissue (WAT) LPL activity delays plasma clearance of TG-rich lipoproteins (TRLs). We reported the secretion of apoC-I, an LPL inhibitor, from WAT ex vivo in women. Therefore we hypothesized that WAT-secreted apoC-I as…
View article: Adenoviral overexpression of AnxA2 in mouse liver significantly increases LDLR levels.
Adenoviral overexpression of AnxA2 in mouse liver significantly increases LDLR levels. Open
Empty control (Ad-Ctl) and HA-tagged AnxA2 (Ad-A2) adenoviruses were injected intravenously into the tail vein of WT (A) or Pcsk9−/− (B) mice. After 7 days, livers were analysed for LDLR levels and AnxA2-HA expression by …
View article: Treat-to-target versus dose-adapted statin treatment of cholesterol to reduce cardiovascular risk
Treat-to-target versus dose-adapted statin treatment of cholesterol to reduce cardiovascular risk Open
Clinical guidelines should be based on the best available evidence and are of great importance for patient care and disease prevention. In this respect, the 2013 American College of Cardiology/American Heart Association report is highly ap…