Justin T. Denholm
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View article: Bringing tuberculosis genomics to the clinic: development and validation of a comprehensive pipeline to predict antimicrobial susceptibility from genomic data, accredited to ISO standards
Bringing tuberculosis genomics to the clinic: development and validation of a comprehensive pipeline to predict antimicrobial susceptibility from genomic data, accredited to ISO standards Open
Department of Health Victoria and Medical Research Future Fund.
View article: Predictors of unsuccessful tuberculosis treatment outcome in Bhutan: A retrospective study using comprehensive national tuberculosis surveillance data
Predictors of unsuccessful tuberculosis treatment outcome in Bhutan: A retrospective study using comprehensive national tuberculosis surveillance data Open
Introduction Tuberculosis is a significant public health problem in Bhutan. Effective treatment is the key to TB elimination but information on treatment outcomes in Bhutan is limited. To improve TB control efforts in Bhutan, we assessed T…
View article: Extensive endemic transmission of multidrug-resistant <i>Mycobacterium tuberculosis</i> in Bhutan: A retrospective genomic-epidemiological study
Extensive endemic transmission of multidrug-resistant <i>Mycobacterium tuberculosis</i> in Bhutan: A retrospective genomic-epidemiological study Open
Despite decreasing overall tuberculosis notifications, the proportion of multidrug-resistant tuberculosis (MDR-TB) cases are increasing in Bhutan. While most MDR-TB cases are diagnosed among patients in the bordering districts and the capi…
View article: TB-related stigma is widely prevalent among people with TB and carers in Mongolia
TB-related stigma is widely prevalent among people with TB and carers in Mongolia Open
BACKGROUNDIn Mongolia, estimated TB incidence is high, but treatment coverage is low. Stigma is a likely barrier to access but has not previously been evaluated.METHODSWe conducted a national TB stigma assessment in Mongolia in 2021–2022 t…
View article: <scp><i>Mycobacterium abscessus</i></scp> Pulmonary Disease in a Myasthenia Gravis Patient: A Case Report
<span><i>Mycobacterium abscessus</i></span> Pulmonary Disease in a Myasthenia Gravis Patient: A Case Report Open
There is limited guidance on managing Mycobacterium abscessus pulmonary disease in Myasthenia Gravis patients. Macrolides and aminoglycosides form the backbone of M. abscessus pulmonary disease treatment but are avoided in Myasthenia Gravi…
View article: An Update on the Clinical Management of HIV and Tuberculosis Co-Infection in Pregnancy: TB Preventative Therapy, Long-Acting ARVs, and Bedaquiline-Based Regimens
An Update on the Clinical Management of HIV and Tuberculosis Co-Infection in Pregnancy: TB Preventative Therapy, Long-Acting ARVs, and Bedaquiline-Based Regimens Open
Purpose This update addresses HIV/TB co-infection management in pregnancy, focusing on new treatment options. Recent Findings Pregnancy with HIV increases TB risk and worsens treatment outcomes. While long-acting antiretroviral therapies (…
View article: Antenatal screening for TB disease: a systematic review and meta-analysis
Antenatal screening for TB disease: a systematic review and meta-analysis Open
OBJECTIVESTB disease during pregnancy is associated with poor maternal and neonatal outcomes, and is a leading non-obstetric cause of maternal death. However, optimal detection strategies remain uncertain. We aimed to identify the optimal …
View article: Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies
Spatially resolved integrative analysis of transcriptomic and metabolomic changes in tissue injury studies Open
Recent developments in spatially resolved -omics have enabled studies linking gene expression and metabolite levels to tissue morphology, offering new insights into biological pathways. By capturing multiple modalities on matched tissue se…
View article: Management of tuberculosis infection in a general practice setting: An implemented model of care
Management of tuberculosis infection in a general practice setting: An implemented model of care Open
More than 20 general practices and pharmacies in south-eastern Melbourne have now adopted this model of care, involving community-based education, diagnosis and treatment, which has been integrated into existing practice approaches. A rang…
View article: A systemic review of the utility of antituberculosis therapy for presumed tuberculous uveitis
A systemic review of the utility of antituberculosis therapy for presumed tuberculous uveitis Open
Background Uveitis presumed to be secondary to Mycobacterium tuberculosis is a rare but potentially blinding condition. Difficulty in making an accurate diagnosis and the low incidence of TB uveitis (TBU) contribute to the lack of evidence…
View article: Mycobacterium tuberculosis infection in pregnancy: A systematic review
Mycobacterium tuberculosis infection in pregnancy: A systematic review Open
Pregnancy may be associated with risk of developing tuberculosis (TB) in those infected with Mycobacterium tuberculosis ( Mtb ). The perinatal period could provide opportunities for targeted screening and treatment. This study aims to synt…
View article: Building social equity and person-centred innovation into the end TB response
Building social equity and person-centred innovation into the end TB response Open
Reducing systemic inequities in testing, access to care, social protection – and in the scientific process – is essential to end TB. Incorporating social science methods and expertise on inequity into the mainstream TB response would help …
View article: Considering best practice standards for routine whole-genome sequencing for TB care and control
Considering best practice standards for routine whole-genome sequencing for TB care and control Open
TB is a priority pathogen for the application of whole-genome sequencing (WGS) into routine public health practice. In low-incidence settings, a growing number of services have begun to incorporate routine WGS into standard practice. The i…
View article: <i>Mycobacterium tuberculosis</i>infection in pregnancy: a systematic review
<i>Mycobacterium tuberculosis</i>infection in pregnancy: a systematic review Open
Pregnancy may be associated with risk of developing tuberculosis (TB) in those infected with Mycobacterium tuberculosis ( Mtb ). The perinatal period could provide opportunities for targeted screening and treatment. This study aims to synt…
View article: Overlooked, dismissed, and downplayed: reversion of<i>Mycobacterium tuberculosis</i>immunoreactivity
Overlooked, dismissed, and downplayed: reversion of<i>Mycobacterium tuberculosis</i>immunoreactivity Open
Tuberculosis (TB) is caused by Mycobacterium tuberculosis ( Mtb ). Following infection, immune responses to Mtb antigens can be measured using the tuberculin skin test or an interferon-γ release assay. The gain of Mtb immunoreactivity, a c…
View article: Developing best practice public health standards for whole genome sequencing of Mycobacterium tuberculosis
Developing best practice public health standards for whole genome sequencing of Mycobacterium tuberculosis Open
Mycobacterium tuberculosis is a priority pathogen for global control. A growing number of countries have begun to incorporate routine whole genome sequencing (WGS) to support key aspects of tuberculosis (TB) public health and clinical prac…
View article: Community voices and whole genome sequencing for tuberculosis: storytelling and the importance of listening
Community voices and whole genome sequencing for tuberculosis: storytelling and the importance of listening Open
One of the primary public health functions of a tuberculosis (TB) program is to arrest the spread of infection. Traditionally, TB programs have relied on epidemiological information, gathered through contact tracing, to infer that transmis…
View article: Clinician perceptions of research priorities for the management of noncritically ill patients admitted to hospital with <scp>SARS‐CoV‐2</scp> infection
Clinician perceptions of research priorities for the management of noncritically ill patients admitted to hospital with <span>SARS‐CoV‐2</span> infection Open
The changing phenotype of coronarvirus disease 2019 (COVID‐19) may quickly render guideline‐recommended interventions obsolete. We developed a 40‐question clinician survey in consultation with the Australasian COVID‐19 Trial site investiga…
View article: The prevalence of tuberculosis infection among foreign-born Canadians: a modelling study
The prevalence of tuberculosis infection among foreign-born Canadians: a modelling study Open
About 1 in 4 foreign-born Canadian residents has tuberculosis infection, but very few were infected within the 2 preceding years (the highest risk period for progression to tuberculosis disease). These data may inform future tuberculosis i…
View article: Standards for clinical trials for treating TB
Standards for clinical trials for treating TB Open
BACKGROUND: The value, speed of completion and robustness of the evidence generated by TB treatment trials could be improved by implementing standards for best practice. METHODS: A global panel of experts participated in a Delphi process, …
View article: The APPRISE Virtual Biobank for Infectious Diseases
The APPRISE Virtual Biobank for Infectious Diseases Open
The Australian Partnership for Preparedness Research on InfectiouS disease Emergencies (APPRISE) has developed a virtual biobank to support infectious disease research in Australia. The virtual biobank (https://apprise.biogrid.org.au) inte…
View article: Whole genome sequencing of drug-resistant Mycobacterium tuberculosis isolates in Victoria, Australia
Whole genome sequencing of drug-resistant Mycobacterium tuberculosis isolates in Victoria, Australia Open
Isoniazid-resistant TB is the commonest DR-TB in Victoria, and the mutation profile is similar to global circulating DR-TB. Most cases are diagnosed among migrants with limited transmission. This study highlights the value of WGS in identi…
View article: Bringing TB genomics to the clinic: A comprehensive pipeline to predict antimicrobial susceptibility from genomic data, validated and accredited to ISO standards
Bringing TB genomics to the clinic: A comprehensive pipeline to predict antimicrobial susceptibility from genomic data, validated and accredited to ISO standards Open
Background Whole genome sequencing (WGS) is increasingly contributing to the clinical management of tuberculosis. Whilst the availability of bioinformatic tools for analysis and clinical reporting of Mycobacterium tuberculosis sequence dat…
View article: Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort
Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort Open
Background Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods We collected d…
View article: Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby
Pre-extensively Drug-Resistant Congenital Tuberculosis in an Extremely Premature Baby Open
We describe a case of congenital tuberculosis in an extremely premature baby, with rapid molecular detection of a pre-extensively drug-resistant (XDR) pattern of drug resistance. The baby was treated successfully with a regimen including b…
View article: Multidisciplinary Teams for the Management of Infective Endocarditis: A Systematic Review and Meta-analysis
Multidisciplinary Teams for the Management of Infective Endocarditis: A Systematic Review and Meta-analysis Open
Background The management of infective endocarditis (IE) is complex owing to a high burden of morbidity and mortality. Recent guidelines recommend dedicated multidisciplinary teams (MDTs) for the management of IE. The aim of this systemati…
View article: Guidelines for Diagnosis and Management of Infective Endocarditis in Adults
Guidelines for Diagnosis and Management of Infective Endocarditis in Adults Open
Importance Practice guidelines often provide recommendations in which the strength of the recommendation is dissociated from the quality of the evidence. Objective To create a clinical guideline for the diagnosis and management of adult ba…