John De Vos
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View article: Securing raw materials, reagents, and consumable supplies in the academic bioproduction UNITC network: because the chain is only as strong as its weakest link
Securing raw materials, reagents, and consumable supplies in the academic bioproduction UNITC network: because the chain is only as strong as its weakest link Open
Academic autologous cell manufacturing offers key advantages, including cost-effectiveness, accessibility, and flexibility. However, the management of Raw Materials, Reagents, and Consumables (RMRCs) is essential for ensuring product purit…
View article: The Combined Expression Profiles of Epigenetic Biomarkers Reveal Heterogeneity in Normospermic Human Sperm Samples
The Combined Expression Profiles of Epigenetic Biomarkers Reveal Heterogeneity in Normospermic Human Sperm Samples Open
Background: Male infertility is evaluated using standard semen parameters. However, these criteria offer limited insight into sperm functionality and poorly predict natural fertility or assisted reproductive technology (ART) outcomes. Meth…
View article: Genome-Wide microRNA Expression Profiling in Human Spermatozoa and Its Relation to Sperm Quality
Genome-Wide microRNA Expression Profiling in Human Spermatozoa and Its Relation to Sperm Quality Open
Background: Sperm samples are separated into bad and good quality samples in function of their phenotype, but this does not indicate their genetic quality. Methods: Here, we used GeneChip miRNA arrays to analyze microRNA expression in ten …
View article: Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell–based therapeutics
Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell–based therapeutics Open
By applying a Delphi method to establish a consensus definition for MSCs and reporting guidelines for MSC-based clinical trials, this work represents a significant advance in improving transparency and reproducibility in the conduct and re…
View article: Pharmacometabolomics applied to low‐dose interleukin‐2 treatment in amyotrophic lateral sclerosis
Pharmacometabolomics applied to low‐dose interleukin‐2 treatment in amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease. The immunosuppressive functions of regulatory T lymphocytes (Tregs) are impaired in ALS, and correlate to disease progression. The phase 2a IMODALS trial reported a…
View article: Generation of a healthy heavy smoker patient-derived induced pluripotent stem cell line UHOMi007-A from peripheral blood mononuclear cells
Generation of a healthy heavy smoker patient-derived induced pluripotent stem cell line UHOMi007-A from peripheral blood mononuclear cells Open
Human pluripotent stem cells (hiPSC) represent a unique opportunity to model lung development and chronic bronchial diseases. We generated a hiPSC line from a highly characterized healthy heavy smoker male donor free from emphysema or toba…
View article: Geochronology and palaeoenvironments of Sibrambang and Djambu caves, western Sumatra
Geochronology and palaeoenvironments of Sibrambang and Djambu caves, western Sumatra Open
Fossils from Sibrambang and Djambu, two sites in the Padang Highlands, were collected by Dubois in the late 1880s.These collections, alongside the deposits from Lida Ajer, have for over 100 years been our only insights into the Pleistocene…
View article: Diversity, population structure and palaeoecology of the Pleistocene large cervids from the Padang Highlands, Sumatra
Diversity, population structure and palaeoecology of the Pleistocene large cervids from the Padang Highlands, Sumatra Open
This chapter deals with the dentognathic remains of the Late Pleistocene large cervids from the Padang Highlands caves in Sumatra. We used linear and geometric morphometric techniques to investigate variation, taxonomic position and body s…
View article: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Studies of climate variation commonly rely on chemical and isotopic changes recorded in sequentially produced growth layers, such as in corals, shells, and tree rings, as well as in accretionary deposits—ice and sediment cores, and speleot…
View article: Author Response: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Author Response: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Full text Figures and data Side by side Abstract eLife assessment eLife digest Introduction Results Discussion Materials and methods Appendix 1 Data availability References Peer review Author response Article and author information Abstrac…
View article: Author Response: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Author Response: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Studies of climate variation commonly rely on chemical and isotopic changes recorded in sequentially-produced growth layers, such as in corals, shells and tree rings, as well as in accretionary deposits—ice and sediment cores, and speleoth…
View article: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Studies of climate variation commonly rely on chemical and isotopic changes recorded in sequentially-produced growth layers, such as in corals, shells and tree rings, as well as in accretionary deposits—ice and sediment cores, and speleoth…
View article: S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
S100A alarmins and thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty Open
Rationale Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe asthma after conside…
View article: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Studies of climate variation commonly rely on chemical and isotopic changes recorded in sequentially produced growth layers, such as in corals, shells, and tree rings, as well as in accretionary deposits—ice and sediment cores, and speleot…
View article: Author Response: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Author Response: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Studies of climate variation commonly rely on chemical and isotopic changes recorded in sequentially-produced growth layers, such as in corals, shells and tree rings, as well as in accretionary deposits—ice and sediment cores, and speleoth…
View article: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Studies of climate variation commonly rely on chemical and isotopic changes recorded in sequentially-produced growth layers, such as in corals, shells and tree rings, as well as in accretionary deposits—ice and sediment cores, and speleoth…
View article: S100 A alarmins and Thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty
S100 A alarmins and Thymic stromal lymphopoietin (TSLP) regulation in severe asthma following bronchial thermoplasty Open
Rationale : Severe asthma affects a small proportion of asthmatics but represents a significant healthcare challenge. Bronchial thermoplasty (BT) is an interventional treatment approach preconized for uncontrolled severe asthma after consi…
View article: The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2
The Transcriptome Landscape of the In Vitro Human Airway Epithelium Response to SARS-CoV-2 Open
Airway–liquid interface cultures of primary epithelial cells and of induced pluripotent stem-cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant models for respiratory virus infection studies beca…
View article: Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation
Oxygen isotopes in orangutan teeth reveal recent and ancient climate variation Open
Studies of climate variation commonly rely on chemical and isotopic changes recorded in sequentially-produced growth layers, such as in corals, shells and tree rings, as well as in accretionary deposits—ice and sediment cores, and speleoth…
View article: Editorial: Human behavior, cognition, and environmental interactions for the lower paleolithic
Editorial: Human behavior, cognition, and environmental interactions for the lower paleolithic Open
The Lower Paleolithic is commonly considered as a long period ca. 3.3 to 0.3 Ma, from
\nthe earliest evidence of lithic production to the apparition of new core technologies, such as
\nthe Levallois. Several Hominins (i.e., Australopithecu…
View article: Human airway ex vivo models: new tools to study the airway epithelial cell response to SARS-CoV-2 infection
Human airway ex vivo models: new tools to study the airway epithelial cell response to SARS-CoV-2 infection Open
Airway-liquid interface cultures of primary epithelial cells and of induced pluripotent stem cell-derived airway epithelial cells (ALI and iALI, respectively) are physiologically relevant models for respiratory virus infection studies beca…
View article: Data from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
Data from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase Open
Human mesenchymal stem cells (MSC) strongly repress activated T-cell proliferation through the production of a complex set of soluble factors, including the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO), which is induced…
View article: Supplementary Figure Legends 1-3 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
Supplementary Figure Legends 1-3 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase Open
Supplementary Figure Legends 1-3 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
View article: Supplementary Figure 1 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
Supplementary Figure 1 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase Open
Supplementary Figure 1 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
View article: Supplementary Figure 2 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
Supplementary Figure 2 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase Open
Supplementary Figure 2 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
View article: Supplementary Figure Legends 1-3 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase
Supplementary Figure Legends 1-3 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase Open
Supplementary Figure Legends 1-3 from Functional Alteration of the Lymphoma Stromal Cell Niche by the Cytokine Context: Role of Indoleamine-2,3 Dioxygenase