James E. Jackson
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View article: The Challenge of Handling Structured Missingness in Integrated Data Sources
The Challenge of Handling Structured Missingness in Integrated Data Sources Open
As data integration becomes ever more prevalent, a new research question that emerges is how to handle missing values that will inevitably arise in these large‐scale integrated databases? This missingness can be described as structured mis…
View article: Electrocatalytic conversion of biomass-derived oxygenated aromatics to cycloalkanes
Electrocatalytic conversion of biomass-derived oxygenated aromatics to cycloalkanes Open
Electrocatalytic transformation of oxygenated aromatics to cycloalkanes on activated carbon cloth-supported ruthenium and platinum under mild conditions (≤60°, atmospheric pressure) using hydrogen equivalents produced in situ by water spli…
View article: Syn vs. Anti? What Controls Addition Stereochemistry in Chlorolactonization
Syn vs. Anti? What Controls Addition Stereochemistry in Chlorolactonization Open
The stereochemistry of the uncatalyzed chlorolactonization of 4‐phenylpent‐4‐enoic acid at room temperature was examined to probe the reaction's intrinsic diastereoselectivities as a function of chlorenium ion donor, solvent polarity, and …
View article: Mechanistic Insight into the Thermal “Blueing” of Cyanine Dyes
Mechanistic Insight into the Thermal “Blueing” of Cyanine Dyes Open
In recent work to develop cyanine dyes with especially large Stokes shifts, we encountered a "blueing" reaction, in which the heptamethine cyanine dye Cy7 (IUPAC: 1,3,3-trimethyl-2-((1E,3E,5E)-7-((E)-1,3,3-trimethylindolin-2-ylidene)hepta-…
View article: Electrocatalytic hydrogenation of the formyl group and heteroaromatic ring in furfural on activated carbon cloth-supported ruthenium
Electrocatalytic hydrogenation of the formyl group and heteroaromatic ring in furfural on activated carbon cloth-supported ruthenium Open
Electrocatalytic transformation of furfural to tetrahydrofurfuryl alcohol on activated carbon cloth-supported ruthenium at mild conditions (≤ 50 °C under atmospheric pressure) using hydrogen equivalents produced in situ by water splitting.
View article: A Complete Characterisation of Structured Missingness
A Complete Characterisation of Structured Missingness Open
Our capacity to process large complex data sources is ever-increasing, providing us with new, important applied research questions to address, such as how to handle missing values in large-scale databases. Mitra et al. (2023) noted the phe…
View article: Process for the preparation of lactic acid and glyceric acid
Process for the preparation of lactic acid and glyceric acid Open
Hexose and pentose monosaccharides are degraded to lactic acid and glyceric acid in an aqueous solution in the presence of an excess of a strongly anionic exchange resin, such as AMBERLITE IRN78 and AMBERLITE IRA400. The glyceric acid and …
View article: Electrocatalytic hydrogenation and hydrodeoxygenation of oxygenated and unsaturated organic compounds
Electrocatalytic hydrogenation and hydrodeoxygenation of oxygenated and unsaturated organic compounds Open
A process and related electrode composition are disclosed for the electrocatalytic hydrogenation and/or hydrodeoxygenation of organic substrates such as biomass-derived bio-oil components by the production of hydrogen atoms on a catalyst s…
View article: Mild, Electroreductive Lignin Cleavage: Optimizing the Depolymerization of Authentic Lignins
Mild, Electroreductive Lignin Cleavage: Optimizing the Depolymerization of Authentic Lignins Open
Among candidate strategies to depolymerize lignin, electroreduction has promise as a mild, environmentally friendly, low-cost method to cleave lignin’s most common linkage, the β-O-4 bond. Much of the prior work on lignin electrolysis has …
View article: On integrating the number of synthetic data sets $m$ into the 'a priori' synthesis approach
On integrating the number of synthetic data sets $m$ into the 'a priori' synthesis approach Open
Until recently, multiple synthetic data sets were always released to analysts, to allow valid inferences to be obtained. However, under certain conditions - including when saturated count models are used to synthesize categorical data - si…
View article: Pathways to research leadership for early career researchers in Africa: A potential role for African and Global Funders
Pathways to research leadership for early career researchers in Africa: A potential role for African and Global Funders Open
Early career researchers at African universities face numerous challenges and demands within a context of minimum resources; yet on the other hand, there is significant expectation for doing excellent science that is of high quality with i…
View article: Excited-State Dynamics of a Substituted Fluorene Derivative. The Central Role of Hydrogen Bonding Interactions with the Solvent
Excited-State Dynamics of a Substituted Fluorene Derivative. The Central Role of Hydrogen Bonding Interactions with the Solvent Open
Substituted fluorene structures have demonstrated unusual photochemical properties. Previous reports on the substituted fluorene Schiff base FR0-SB demonstrated super photobase behavior with a ΔpKb of ∼14 upon photoexcitation. In an effort…
View article: Femtosecond dynamics and coherence of ionic retro-Diels–Alder reactions
Femtosecond dynamics and coherence of ionic retro-Diels–Alder reactions Open
Ultrafast tunnel ionization enables femtosecond time-resolved dynamic measurements of the retro-Diels–Alder reactions of positively charged cyclohexene, norbornene, and dicyclopentadiene. Unlike the reaction times of 500–600 ps that are ob…
View article: Using saturated count models for user-friendly synthesis of categorical data
Using saturated count models for user-friendly synthesis of categorical data Open
Over the past three decades, synthetic data methods for statistical disclosure control have continually evolved, but mainly within the domain of survey data sets. There are certain characteristics of administrative databases, such as their…
View article: Thio-assisted reductive electrolytic cleavage of lignin β-O-4 models and authentic lignin
Thio-assisted reductive electrolytic cleavage of lignin β-O-4 models and authentic lignin Open
Disulfide-enhanced electroreductive cleavage of oxidized lignin β-O-4 dimers.
View article: A chiroptical approach for the absolute stereochemical determination of <i>P</i>-stereogenic centers
A chiroptical approach for the absolute stereochemical determination of <i>P</i>-stereogenic centers Open
A simple chiroptical solution for the absolute stereochemical determination for asymmetric phosphorus V stereocenters is presented.
View article: Nucleophilic Thiols Reductively Cleave Ether Linkages in Lignin Model Polymers and Lignin
Nucleophilic Thiols Reductively Cleave Ether Linkages in Lignin Model Polymers and Lignin Open
Lignin may serve as a renewable feedstock for the production of chemicals and fuels if mild, scalable processes for its depolymerization can be devised. The use of small organic thiols represents a bioinspired strategy to cleave the β‐O‐4 …
View article: Multiple Mechanisms Mapped in Aryl Alkyl Ether Cleavage via Aqueous Electrocatalytic Hydrogenation over Skeletal Nickel
Multiple Mechanisms Mapped in Aryl Alkyl Ether Cleavage via Aqueous Electrocatalytic Hydrogenation over Skeletal Nickel Open
We present here detailed mechanistic studies of electrocatalytic hydrogenation (ECH) in aqueous solution over skeletal nickel cathodes to probe the various paths of reductive catalytic C-O bond cleavage among functionalized aryl ethers rel…
View article: Electroactivated alkylation of amines with alcohols <i>via</i> both direct and indirect borrowing hydrogen mechanisms
Electroactivated alkylation of amines with alcohols <i>via</i> both direct and indirect borrowing hydrogen mechanisms Open
Aqueous electrocatalytic alkylation of amines with alcohol; water is the only byproduct.
View article: Steric effects in light-induced solvent proton abstraction
Steric effects in light-induced solvent proton abstraction Open
The significance of solvent structural factors in the excited-state proton transfer reactions of the super photobase FR0-SB with alcohols is examined using steady-state and time-resolved spectroscopy and quantum chemistry computations.
View article: Electrocatalytic cleavage of lignin model dimers using ruthenium supported on activated carbon cloth
Electrocatalytic cleavage of lignin model dimers using ruthenium supported on activated carbon cloth Open
Thermally resistant 4-O-5 linked lignin model dimers are cleaved to valuable intermediates under mild conditions with high faradaic efficiency.
View article: Proton Abstraction Mediates Interactions between the Super Photobase FR0-SB and Surrounding Alcohol Solvent
Proton Abstraction Mediates Interactions between the Super Photobase FR0-SB and Surrounding Alcohol Solvent Open
We report on the motional and proton transfer dynamics of the super photobase FR0-SB in the series of normal alcohols C1 (methanol) through C8 (n-octanol) and ethylene glycol. Steady-state and time-resolved fluorescence data reveal that th…
View article: Biomimetic Reductive Cleavage of Keto Aryl Ether Bonds by Small‐Molecule Thiols
Biomimetic Reductive Cleavage of Keto Aryl Ether Bonds by Small‐Molecule Thiols Open
The nucleophilic and reductive properties of thiolates and thiols make them ideal candidates as redox mediators via the thiol/disulfide couple. One mechanism for biological lignin depolymerization entails reduction of keto aryl ether bonds…
View article: CCDC 1914526: Experimental Crystal Structure Determination
CCDC 1914526: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1871106: Experimental Crystal Structure Determination
CCDC 1871106: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1871115: Experimental Crystal Structure Determination
CCDC 1871115: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Absolute and relative facial selectivities in organocatalytic asymmetric chlorocyclization reactions
Absolute and relative facial selectivities in organocatalytic asymmetric chlorocyclization reactions Open
For four related 1,1-disubstituted olefins, (DHQD)2PHAL-catalyzed asymmetric chlorocyclization delivers Cl+uniformly to one π face, but cyclizes with strong but differing netsyn vs. antiaddition.