Bettina E. Hansen
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View article: Development and validation of a case identification algorithm for hand trauma patients using health administrative data and the epidemiology of hand trauma in a universal healthcare system.
Development and validation of a case identification algorithm for hand trauma patients using health administrative data and the epidemiology of hand trauma in a universal healthcare system. Open
Our algorithm enabled identification of hand trauma cases using health administrative data suitable for population-level surveillance and health services research, revealing a rising burden of hand trauma from 1993 to 2023. These findings …
View article: Expanding the Focus on Work Factors in an Outpatient Setting: Does a Nudge of Patients and Clinicians have an Effect on Return-to-Work and Benefits? Findings from the NSAC Nudge Multicentre Randomised Controlled Trial
Expanding the Focus on Work Factors in an Outpatient Setting: Does a Nudge of Patients and Clinicians have an Effect on Return-to-Work and Benefits? Findings from the NSAC Nudge Multicentre Randomised Controlled Trial Open
Purpose The purpose of the study was to test the effects of a nudge on patients return-to-work (RTW) and benefits in a clinical service aimed to promote RTW and prevent sickness absence in patients referred for musculoskeletal disorders or…
View article: Yogurt reintroduction and the circulating microbiome in healthy volunteers: protocol for a prospective, longitudinal, species-controlled crossover clinical trial (MAMI)
Yogurt reintroduction and the circulating microbiome in healthy volunteers: protocol for a prospective, longitudinal, species-controlled crossover clinical trial (MAMI) Open
NCT06944002.
View article: Elevated Serum Bile Acids Predict Poor Liver Outcomes in Children With Alagille Syndrome: Results From the <scp>GALA</scp> Study Group
Elevated Serum Bile Acids Predict Poor Liver Outcomes in Children With Alagille Syndrome: Results From the <span>GALA</span> Study Group Open
Background and Aim Alagille syndrome (ALGS) is a rare disorder characterised by cholestasis and extrahepatic manifestations. Given the current era of ileal bile acid transporter (IBAT) inhibitor therapies that reduce serum bile acid (SBA) …
View article: HBsAg decline and clearance with peg-IFN therapy added to nucleos(t)ide analogues: an individual participant data meta-analysis of prospective trials (PROSPER)
HBsAg decline and clearance with peg-IFN therapy added to nucleos(t)ide analogues: an individual participant data meta-analysis of prospective trials (PROSPER) Open
Background Peg-interferon (peg-IFN) plays an increasingly important role in HBV cure strategies, either in combination with novel antivirals, as a lead-in or as consolidation treatment. Objective We aimed to provide estimates of hepatitis …
View article: High biochemical remission rates in patients with primary biliary cholangitis treated with “triple” anticholestatic therapy
High biochemical remission rates in patients with primary biliary cholangitis treated with “triple” anticholestatic therapy Open
Background: Treatment goals in primary biliary cholangitis (PBC) are increasingly aspirational, aiming for normal serum liver tests. One of the add-on therapies to ursodeoxycholic acid (UDCA) is with the approved farnesoid X receptor (FXR)…
View article: Prediction of Hepatocellular Carcinoma and Other Liver‐Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction‐Associated Steatotic Liver Disease
Prediction of Hepatocellular Carcinoma and Other Liver‐Related Events in Chronic Hepatitis B Patients With Metabolic Dysfunction or Metabolic Dysfunction‐Associated Steatotic Liver Disease Open
Introduction Metabolic dysfunction and metabolic dysfunction‐associated steatotic liver disease (MASLD) are associated with an increased risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). We aimed to study r…
View article: Phenotypic Divergence of <i>JAG1</i> ‐ and <i>NOTCH2</i> ‐Associated Alagille Syndrome & Disease‐Specific <i>NOTCH2</i> Variant Classification Guidelines
Phenotypic Divergence of <i>JAG1</i> ‐ and <i>NOTCH2</i> ‐Associated Alagille Syndrome & Disease‐Specific <i>NOTCH2</i> Variant Classification Guidelines Open
Background & Aims Alagille syndrome (ALGS) is a rare, autosomal dominant disorder with high phenotypic heterogeneity. Disease‐causing variants are primarily identified in Jagged1 ( JAG1 ), with fewer reported in NOTCH2 . JAG1 variants caus…
View article: Endoscopic retrograde cholangiopancreatography and primary sclerosing cholangitis: a retrospective study of a high-volume program
Endoscopic retrograde cholangiopancreatography and primary sclerosing cholangitis: a retrospective study of a high-volume program Open
Background Endoscopic retrograde cholangiopancreatography (ERCP) is valuable in management of primary sclerosing cholangitis (PSC). Herein, we characterize individuals with PSC who underwent ERCP on-demand at a high-volume quaternary centr…
View article: Effects of one month of intermittent fasting on the blood microbiome in healthy volunteers (OMIF): A randomized controlled crossover study protocol
Effects of one month of intermittent fasting on the blood microbiome in healthy volunteers (OMIF): A randomized controlled crossover study protocol Open
NCT06678516.
View article: Longitudinal study of blood microbiome responses to milk reintroduction in healthy volunteers: A prospective, single-arm crossover study protocol
Longitudinal study of blood microbiome responses to milk reintroduction in healthy volunteers: A prospective, single-arm crossover study protocol Open
Background The gut microbiome is crucial for maintaining overall host homeostasis and metabolism, but it can be significantly affected by dietary changes, leading to substantial temporal variations in microbial composition both within and …
View article: Association of Metabolic Comorbidities With Fibrosis Severity and Fibrosis Regression in Patients With Chronic Hepatitis B
Association of Metabolic Comorbidities With Fibrosis Severity and Fibrosis Regression in Patients With Chronic Hepatitis B Open
Presence of metabolic comorbidities in untreated CHB patients is associated with more severe liver fibrosis and, after initiation of antiviral therapy, with less fibrosis regression and a higher risk of fibrosis progression.
View article: Genome-Wide Methylation Sequencing to Identify DNA Methylation Markers for Early-stage Hepatocellular Carcinoma in Liver and Blood
Genome-Wide Methylation Sequencing to Identify DNA Methylation Markers for Early-stage Hepatocellular Carcinoma in Liver and Blood Open
Background Hepatocellular carcinoma (HCC) is associated with a poor 5-year survival mainly due to detection at late stages. Better non-invasive surveillance methods are needed to improve early detection and maximize survival. We performed …
View article: Direct-acting antivirals lower mortality and recurrence in HCV-related hepatocellular carcinoma post liver resection: A multicenter international study
Direct-acting antivirals lower mortality and recurrence in HCV-related hepatocellular carcinoma post liver resection: A multicenter international study Open
Direct-acting antiviral therapy is associated with improved 5-year overall and recurrence-free survival, without significantly increased risk of 90-day postoperative complications, in patients undergoing liver resection for hepatitis C vir…
View article: Development of a Question Prompt List for People Living With Primary Biliary Cholangitis: A Delphi Study
Development of a Question Prompt List for People Living With Primary Biliary Cholangitis: A Delphi Study Open
The PBC patient question prompt list serves as a user-facing document, to enhance the patient experience, and drive value-based healthcare in routine clinical practice.
View article: The global prevalence and impact of steatotic liver disease and viral infections: A systematic review and meta-analysis
The global prevalence and impact of steatotic liver disease and viral infections: A systematic review and meta-analysis Open
Background: Steatotic liver disease (SLD) affects ~30% of adults worldwide. The global population is continuously threatened by epidemic and endemic viral diseases. This study aims to thoroughly examine the interaction between SLD and majo…
View article: Esophageal <i>Candida</i> Infection and Esophageal Cancer Risk in Patients With Achalasia
Esophageal <i>Candida</i> Infection and Esophageal Cancer Risk in Patients With Achalasia Open
Importance Patients with achalasia face a higher risk of developing esophageal cancer (EC), but the surveillance strategies for these patients remain controversial due to the long disease duration and the lack of identified risk factors. O…
View article: P1222 The macroscopic and microscopic distribution of IBD in patients with PSC: a polytomous latent class analysis on 3177 endoscopies
P1222 The macroscopic and microscopic distribution of IBD in patients with PSC: a polytomous latent class analysis on 3177 endoscopies Open
Background Inflammatory bowel disease (IBD) in patients with primary sclerosing cholangitis (PSC) is a distinct disease entity requiring specific management1. Data on characterisation of the phenotype of PSC-IBD are limited and subclassifi…
View article: Hepatic real-world outcomes with obeticholic acid in primary biliary cholangitis (HEROES): A trial emulation study design
Hepatic real-world outcomes with obeticholic acid in primary biliary cholangitis (HEROES): A trial emulation study design Open
Background and Aims: Primary biliary cholangitis is a rare, progressive liver disease. Obeticholic acid (OCA) received accelerated approval for treating patients with primary biliary cholangitis in whom ursodeoxycholic acid failed, based o…
View article: Early <scp>HBcrAg</scp> and Anti‐<scp>HBc</scp> Levels Identify Patients at High Risk for Severe Flares After Nucleos(t)ide Analogue Cessation—A Pooled Analysis of Two Clinical Trials
Early <span>HBcrAg</span> and Anti‐<span>HBc</span> Levels Identify Patients at High Risk for Severe Flares After Nucleos(t)ide Analogue Cessation—A Pooled Analysis of Two Clinical Trials Open
Background Severe flares (ALT ≥ 10×ULN) are a well‐recognised adverse outcome after nucleos(t)ide analogue (NA) cessation and may lead to liver failure. Thus, identification of patients at risk for these flares is of major importance. Meth…
View article: Glacial rock flour increases photosynthesis and biomass of natural phytoplankton communities in subtropical surface waters: a potential means of action for marine CO2 removal
Glacial rock flour increases photosynthesis and biomass of natural phytoplankton communities in subtropical surface waters: a potential means of action for marine CO2 removal Open
Photosynthesis by phytoplankton reduces partial pressure of CO 2 at the surface of the ocean and is therefore a potential means of action for a marine CO 2 removal technology. Here we study how glacial rock flour may influence photosynthes…
View article: Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study)
Predictors of hepatic flares after nucleos(t)ide analogue cessation – Results of a global cohort study (RETRACT-B study) Open
not applicable.
View article: The spectrum of acute illness and mortality of children and adolescents presenting to emergency services in Sanghar district hospital, Pakistan: a prospective cohort study
The spectrum of acute illness and mortality of children and adolescents presenting to emergency services in Sanghar district hospital, Pakistan: a prospective cohort study Open
Objective To describe presenting diagnoses and rates and causes of death by age category and sex among children with acute illness brought to a district headquarter hospital in Pakistan. Design Prospective cohort study. Setting Sanghar dis…
View article: Plankton Community Metabolism Variations in Two Temperate Coastal Waters of Contrasting Nutrient Richness
Plankton Community Metabolism Variations in Two Temperate Coastal Waters of Contrasting Nutrient Richness Open
Estuarine ecosystems play a crucial role in global carbon cycling. Understanding the factors controlling plankton metabolism in these regions is critical. This study investigates how contrasting nutrient conditions influence plankton metab…