J. Eric Jelovsek
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View article: Algorithm-Based Clinical Decision Support: Evolving Regulatory Landscape and Best Practices for Local Oversight
Algorithm-Based Clinical Decision Support: Evolving Regulatory Landscape and Best Practices for Local Oversight Open
The potential of algorithm-based clinical decision support (CDS) in healthcare continues to increase with the growing field of artificial intelligence (AI)-enabled CDS. The use of these technologies to support clinicians, patients, and hea…
View article: Phenotyping Men With Lower Urinary Tract Symptoms: Results From the Symptoms of Lower Urinary Tract Dysfunction Research Network
Phenotyping Men With Lower Urinary Tract Symptoms: Results From the Symptoms of Lower Urinary Tract Dysfunction Research Network Open
Aims Men with lower urinary tract symptoms (LUTS) represent a heterogeneous group, and treatment decisions are often based on severity of symptoms and physical examination findings. Identification of clinically meaningful subtypes could al…
View article: Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN): An introduction to the Urinary Urgency Phenotyping Protocol LURN II
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN): An introduction to the Urinary Urgency Phenotyping Protocol LURN II Open
Aims The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is undertaking a new cohort study in LURN II including cases and controls. Methods This new cohort was enrolled to specifically study urinary urgency and urgency …
View article: Apical Suspension Repair for Vaginal Vault Prolapse
Apical Suspension Repair for Vaginal Vault Prolapse Open
Importance The optimal surgical repair of vaginal vault prolapse after hysterectomy remains undetermined. Objective To compare the efficacy and safety of 3 surgical approaches for vaginal vault prolapse after hysterectomy. Design, Setting,…
View article: Translating ethical and quality principles for the effective, safe and fair development, deployment and use of artificial intelligence technologies in healthcare
Translating ethical and quality principles for the effective, safe and fair development, deployment and use of artificial intelligence technologies in healthcare Open
Objective The complexity and rapid pace of development of algorithmic technologies pose challenges for their regulation and oversight in healthcare settings. We sought to improve our institution’s approach to evaluation and governance of a…
View article: Longitudinal Fluctuations in Treatment Response After OnabotulinumToxinA and Sacral Neuromodulation for Refractory Urgency Incontinence
Longitudinal Fluctuations in Treatment Response After OnabotulinumToxinA and Sacral Neuromodulation for Refractory Urgency Incontinence Open
Over 6 months after treatment, 2 in 5 women's symptoms fluctuate. Within these initial 6 months, women receiving onabotulinumtoxinA transitioned from success to failure over 30 days less often than sacral neuromodulation. For both treatmen…
View article: Adherence to Perioperative Behavioral Therapy With Pelvic Floor Muscle Training in Women Receiving Vaginal Reconstructive Surgery for Pelvic Organ Prolapse
Adherence to Perioperative Behavioral Therapy With Pelvic Floor Muscle Training in Women Receiving Vaginal Reconstructive Surgery for Pelvic Organ Prolapse Open
Objective The objective of this study was to describe adherence to behavioral and pelvic floor muscle training in women undergoing vaginal reconstructive surgery for organ prolapse and to examine whether adherence was associated with 24-mo…
View article: Postpartum readmission for hypertension and pre‐eclampsia: development and validation of a predictive model
Postpartum readmission for hypertension and pre‐eclampsia: development and validation of a predictive model Open
Objective To develop a model for predicting postpartum readmission for hypertension and pre‐eclampsia at delivery discharge and assess external validation or model transportability across clinical sites. Design Prediction model using data …
View article: Development and validation of models predicting treatment patterns in women with urinary urgency and/or urgency incontinence: A Symptoms of Lower Urinary Tract Dysfunction Research Network observational cohort study
Development and validation of models predicting treatment patterns in women with urinary urgency and/or urgency incontinence: A Symptoms of Lower Urinary Tract Dysfunction Research Network observational cohort study Open
Purpose To develop a tool to predict a woman's treatment pattern for bothersome urinary urgency (UU) and/or UU incontinence over 1 year after presenting for care at urology or urogynecology clinics. Methods The Symptoms of Lower Urinary Tr…
View article: Intraoperative Predictors of Sacral Neuromodulation Implantation and Treatment Response: Results From the ROSETTA Trial
Intraoperative Predictors of Sacral Neuromodulation Implantation and Treatment Response: Results From the ROSETTA Trial Open
Specific parameters routinely assessed intraoperatively during stage 1 sacral neuromodulation for urgency urinary incontinence show limited utility in predicting both acute and long-term outcomes. However, lead position as it relates to th…
View article: Treatment patterns in women with urinary urgency and/or urgency urinary incontinence in the symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort Study
Treatment patterns in women with urinary urgency and/or urgency urinary incontinence in the symptoms of Lower Urinary Tract Dysfunction Research Network Observational Cohort Study Open
Background Limited epidemiological data exist describing how patients engage with various treatments for overactive bladder (OAB). To improve care for patients with OAB, it is essential to gain a better understanding of how patients interf…
View article: Natural history of lower urinary tract symptoms in treatment-seeking women with pelvic organ prolapse; the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN)
Natural history of lower urinary tract symptoms in treatment-seeking women with pelvic organ prolapse; the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Open
View article: Development and Validation of a Model for Opioid Prescribing Following Gynecological Surgery
Development and Validation of a Model for Opioid Prescribing Following Gynecological Surgery Open
This model provides individualized estimates of outpatient opioid use following a range of gynecological surgical procedures for benign and malignant indications with all model inputs available at the time of procedure closing. Implementat…
View article: Development and Validation of a Model for Predicting Surgical Site Infection After Pelvic Organ Prolapse Surgery
Development and Validation of a Model for Predicting Surgical Site Infection After Pelvic Organ Prolapse Surgery Open
Importance Surgical site infection (SSI) is a common and costly complication. Targeted interventions in high-risk patients may lead to a reduction in SSI; at present, there is no method to consistently identify patients at increased risk o…
View article: Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study
Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study Open
We present a methodology for subtyping of persons with a common clinical symptom complex by integrating heterogeneous continuous and categorical data. We illustrate it by clustering women with lower urinary tract symptoms (LUTS), who repre…
View article: A framework for the oversight and local deployment of safe and high-quality prediction models
A framework for the oversight and local deployment of safe and high-quality prediction models Open
Artificial intelligence/machine learning models are being rapidly developed and used in clinical practice. However, many models are deployed without a clear understanding of clinical or operational impact and frequently lack monitoring pla…
View article: Predicting outcomes after intradetrusor onabotulinumtoxina for non‐neurogenic urgency incontinence in women
Predicting outcomes after intradetrusor onabotulinumtoxina for non‐neurogenic urgency incontinence in women Open
Aims Develop models to predict outcomes after intradetrusor injection of 100 or 200 units of onabotulinumtoxinA in women with non‐neurogenic urgency urinary incontinence (UUI). Methods Models were developed using 307 women from two randomi…
View article: Design of a Randomized Controlled Trial of Percutaneous Posterior Tibial Nerve Stimulation for the Treatment of Refractory Fecal Incontinence in Women: The NeurOmodulaTion for Accidental Bowel Leakage Study.
Design of a Randomized Controlled Trial of Percutaneous Posterior Tibial Nerve Stimulation for the Treatment of Refractory Fecal Incontinence in Women: The NeurOmodulaTion for Accidental Bowel Leakage Study. Open
The methods for the NeuromOdulaTion for Accidental Bowel Leakage trial will provide high-level evidence of the effectiveness and optimal maintenance therapy schedule of a low-cost PTNS protocol in community-dwelling women seeking second-li…
View article: Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study
Subtyping of common complex diseases and disorders by integrating heterogeneous data. Identifying clusters among women with lower urinary tract symptoms in the LURN study Open
We present a novel methodology for subtyping of persons with a common clinical symptom complex by integrating heterogeneous continuous and categorical data. We illustrate it by clustering women with lower urinary tract symptoms (LUTS), who…
View article: Subgroups of failure after surgery for pelvic organ prolapse and associations with quality of life outcomes: a longitudinal cluster analysis
Subgroups of failure after surgery for pelvic organ prolapse and associations with quality of life outcomes: a longitudinal cluster analysis Open
View article: Comparison of 100 U With 200 U of Intradetrusor OnabotulinumToxinA for Nonneurogenic Urgency Incontinence
Comparison of 100 U With 200 U of Intradetrusor OnabotulinumToxinA for Nonneurogenic Urgency Incontinence Open
Objectives The objective of this study was to compare efficacy and adverse events between 100 U and 200 U of onabotulinumtoxinA for 6 months in women with nonneurogenic urgency incontinence. Methods This is a secondary analysis of 2 multic…
View article: Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study
Prevalence of childhood trauma and its association with lower urinary tract symptoms in women and men in the LURN study Open
Aims To describe the association between childhood traumas (death of a family member, severe illness, sexual trauma, parental separation) reported by women and men and lower urinary tract symptoms (LUTS). Methods In this secondary analysis…
View article: Success and failure are dynamic, recurrent event states after surgical treatment for pelvic organ prolapse
Success and failure are dynamic, recurrent event states after surgical treatment for pelvic organ prolapse Open
View article: Risk Factors for Surgical Failure and Worsening Pelvic Floor Symptoms Within 5 Years After Vaginal Prolapse Repair
Risk Factors for Surgical Failure and Worsening Pelvic Floor Symptoms Within 5 Years After Vaginal Prolapse Repair Open
OBJECTIVE: To assess independent risk factors for surgical failure and worsening pelvic floor symptoms within 5 years after vaginal prolapse surgery. METHODS: This secondary analysis includes OPTIMAL (Operations and Pelvic Muscle Training …
View article: LBA01-04 INTRAOPERATIVE PREDICTORS OF SACRAL NEUROMODULATION IMPLANTATION & TREATMENT RESPONSE - RESULTS FROM THE ROSETTA TRIAL
LBA01-04 INTRAOPERATIVE PREDICTORS OF SACRAL NEUROMODULATION IMPLANTATION & TREATMENT RESPONSE - RESULTS FROM THE ROSETTA TRIAL Open
You have accessJournal of UrologyLate-Breaking Abstracts (LBA1)1 Apr 2020LBA01-04 INTRAOPERATIVE PREDICTORS OF SACRAL NEUROMODULATION IMPLANTATION & TREATMENT RESPONSE - RESULTS FROM THE ROSETTA TRIAL Bradley Gill*, Cindy L Amundsen, Sonia…
View article: Machine Learning and Statistical Models to Predict Postpartum Hemorrhage
Machine Learning and Statistical Models to Predict Postpartum Hemorrhage Open
OBJECTIVE: To predict a woman's risk of postpartum hemorrhage at labor admission using machine learning and statistical models. METHODS: Predictive models were constructed and compared using data from 10 of 12 sites in the U.S. Consortium …
View article: Reference data on in vitro anatomy and indentation response of tissue layers of musculoskeletal extremities
Reference data on in vitro anatomy and indentation response of tissue layers of musculoskeletal extremities Open
The skin, fat, and muscle of the musculoskeletal system provide essential support and protection to the human body. The interaction between individual layers and their composite structure dictate the body’s response during mechanical loadi…
View article: Characteristics Associated With Clinically Important Treatment Responses in Women Undergoing Nonsurgical Therapy for Fecal Incontinence
Characteristics Associated With Clinically Important Treatment Responses in Women Undergoing Nonsurgical Therapy for Fecal Incontinence Open
OBJECTIVE: To identify baseline clinical and demographic characteristics associated with clinically important treatment responses in a randomized trial of nonsurgical therapies for fecal incontinence (FI). METHODS: Women (N = 296) with FI …
View article: Longitudinal changes in symptom‐based female and male LUTS clusters
Longitudinal changes in symptom‐based female and male LUTS clusters Open
Aims Lower urinary tract symptoms (LUTS) are diverse in type and variable in severity. We examined symptom change within the Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Observational Cohort study identified clus…
View article: Impact of treatment for fecal incontinence on constipation symptoms
Impact of treatment for fecal incontinence on constipation symptoms Open