Joel G. Ray
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View article: SARS-CoV-2 Vaccination and Disorders of Menstruation: A Population-Based Cohort Study
SARS-CoV-2 Vaccination and Disorders of Menstruation: A Population-Based Cohort Study Open
This population-based study evaluated the association between SARS-CoV-2 vaccination and disorders of menstruation among all women in Ontario aged 18-44 years. Study exposure was receipt of a first dose of any SARS-CoV-2 vaccine from Decem…
View article: Multiple Chronic Conditions Before Pregnancy and Risk of Adverse Maternal Health Outcomes: Population‐Based Cohort Study
Multiple Chronic Conditions Before Pregnancy and Risk of Adverse Maternal Health Outcomes: Population‐Based Cohort Study Open
Objective To assess the risks of perinatal emergency department (ED) use, hospitalisation and severe maternal morbidity or mortality (SMM‐M) associated with preconception MCC, according to the number of chronic conditions, complex MCC and …
View article: Does infant birthweight percentile identify mothers at risk of severe morbidity? A Canadian population-based cohort study
Does infant birthweight percentile identify mothers at risk of severe morbidity? A Canadian population-based cohort study Open
Background There is a reverse J-shaped relation between newborn weight percentile and risk of perinatal mortality. Perinatal mortality itself is associated with severe maternal morbidity and mortality (SMM-M) around the index pregnancy, li…
View article: P-620 Polycystic Ovary Syndrome and Severe Maternal Morbidity: A Population-Based Cohort Study
P-620 Polycystic Ovary Syndrome and Severe Maternal Morbidity: A Population-Based Cohort Study Open
Study question Is polycystic ovary syndrome (PCOS) associated with an increased risk of severe maternal morbidity (SMM)? Summary answer PCOS is modestly associated with an increased risk of SMM, independent of the use of fertility treatmen…
View article: P-775 Multifetal pregnancy reduction and ensuing severe maternal and neonatal morbidity and mortality: a population-based cohort study
P-775 Multifetal pregnancy reduction and ensuing severe maternal and neonatal morbidity and mortality: a population-based cohort study Open
Study question How does early multifetal pregnancy reduction impact risk of severe maternal morbidity or mortality (SMM-M) and severe neonatal morbidity or mortality (SNM-M) later in pregnancy? Summary answer Multifetal pregnancy reduction…
View article: Maternal Disability and Emergency Department Use for Infants
Maternal Disability and Emergency Department Use for Infants Open
Importance Infants have among the highest rates of emergency department (ED) visits of all age groups. Women with disabilities experience significant social disparities, may experience barriers accessing child primary care, and may seek ca…
View article: Maternal Downward Neighborhood Income Mobility and Ensuing Severe Neonatal Morbidity
Maternal Downward Neighborhood Income Mobility and Ensuing Severe Neonatal Morbidity Open
This population-based cohort study examines changes in mothers’ neighborhood income between 2 consecutive births and associated morbidity/mortality outcomes in their newborns.
View article: Maternal-newborn ABO Blood Group Congruence Among Consecutive Births and Risk of Serious Neonatal Infection: Retrospective Cohort Study
Maternal-newborn ABO Blood Group Congruence Among Consecutive Births and Risk of Serious Neonatal Infection: Retrospective Cohort Study Open
Background: Differing ABO blood groups between a mother and her fetus may confer a lower risk of serious neonatal infection. How sensitization in the first pregnancy influences this phenomenon in a subsequent pregnancy is unclear. Accordin…
View article: A population-based cohort study of perinatal mental illness following traumatic brain injury
A population-based cohort study of perinatal mental illness following traumatic brain injury Open
Aims To examine the risk of perinatal mental illness, including new diagnoses and recurrent use of mental healthcare, comparing women with and without traumatic brain injury (TBI), and to identify injury-related factors associated with the…
View article: Association between infertility and incident onset of systemic autoimmune rheumatic disease after childbirth: a population-based cohort study
Association between infertility and incident onset of systemic autoimmune rheumatic disease after childbirth: a population-based cohort study Open
STUDY QUESTION What is the association between infertility with or without fertility treatment and incident onset of systemic autoimmune rheumatic disease (SARD) among women who give birth? SUMMARY ANSWER Women who experienced infertility …
View article: Rhabdomyolysis and Sodium-Glucose–Linked Transport Inhibitors in Patients Taking Statins
Rhabdomyolysis and Sodium-Glucose–Linked Transport Inhibitors in Patients Taking Statins Open
This case-control study investigates the risk of rhabdomyolysis among patients receiving sodium-glucose cotransporter-2 (SGLT2) inhibitors.
View article: Cancer chemotherapy in pregnancy and adverse pediatric outcomes: a population-based cohort study
Cancer chemotherapy in pregnancy and adverse pediatric outcomes: a population-based cohort study Open
Background Administration of chemotherapy during pregnancy is often delayed, while preterm delivery is common. If in utero exposure to chemotherapy is associated with adverse pediatric outcomes, it is unknown whether that relationship is d…
View article: Maternal-Newborn ABO Blood Groups and Risk of Bacterial Infection in Newborns
Maternal-Newborn ABO Blood Groups and Risk of Bacterial Infection in Newborns Open
Importance Newborn immunity largely relies on maternal-fetal transfer of antibodies in utero. Incongruency in ABO blood groups between a mother and newborn may be associated with protection against serious infections, but data specific to …
View article: Maternal Downward Neighborhood Income Mobility and Newborn Discharge to Child Protective Services
Maternal Downward Neighborhood Income Mobility and Newborn Discharge to Child Protective Services Open
This cohort study examines whether there is an association between a mother moving into a neighborhood with lower income between births and newborn custody by child protective services at birth.
View article: Exposure to procedural ionizing radiation and cancer risk among physicians
Exposure to procedural ionizing radiation and cancer risk among physicians Open
Background Physicians in certain specialities are routinely exposed to procedural ionizing radiation. Their risk of cancer is unknown, including by cancer sub-types. Aims To assess cancer risk among exposed physicians. Methods This populat…
View article: Mortality Following Childbirth in Ontario: A 20-Year Analysis of Temporal Trends and Causes
Mortality Following Childbirth in Ontario: A 20-Year Analysis of Temporal Trends and Causes Open
Most deaths within 1 year of childbirth are not related to obstetrical factors; however, pregnancy complications factor in early deaths. Causes of early and late deaths differ, but examining late deaths is equally important to identify fac…
View article: Maternal Disability and Early Child Preventive Care
Maternal Disability and Early Child Preventive Care Open
OBJECTIVES Preventive health care for children comprises routine well-child visits and immunizations. Women with physical, sensory, or intellectual or developmental disabilities tend to experience more barriers to preventive health care; y…
View article: Using multi-level regression to determine associations and estimate causes and effects in clinical anesthesia due to patient, practitioner and hospital or health system practice variability
Using multi-level regression to determine associations and estimate causes and effects in clinical anesthesia due to patient, practitioner and hospital or health system practice variability Open
In this research methods tutorial of clinical anesthesia, we will explore techniques to estimate the influence of a myriad of factors on patient outcomes. Big data that contain information on patients , treated by individual anesthesiologi…
View article: Neonatal Adverse Outcomes among Hospital Livebirths in Canada: A National Retrospective Study
Neonatal Adverse Outcomes among Hospital Livebirths in Canada: A National Retrospective Study Open
Introduction: In Canada, newborn morbidity far surpasses mortality. The neonatal adverse outcome indicator (NAOI) summarizes neonatal morbidity, but Canadian trend data are lacking. Methods: This Canada-wide retrospective cross-sectional s…
View article: Procedural abortion, provider‐initiated preterm delivery and survival in pregnant people with cancer: A population‐based cohort study
Procedural abortion, provider‐initiated preterm delivery and survival in pregnant people with cancer: A population‐based cohort study Open
Objective To assess whether procedural‐induced abortion or provider‐initiated preterm delivery are associated with improved survival in pregnant people with cancer. Design Retrospective population‐based cohort study. Setting Provinces of A…
View article: Pregnancy complications and new-onset maternal autoimmune disease
Pregnancy complications and new-onset maternal autoimmune disease Open
Background Autoimmune diseases disproportionately impact women and female-specific aspects of reproduction are thought to play a role. We investigated the time-varying association between pregnancy complications and new-onset autoimmune di…
View article: Trends in rate of hypertensive disorders of pregnancy and associated morbidities in Canada: a population-based study (2012–2021)
Trends in rate of hypertensive disorders of pregnancy and associated morbidities in Canada: a population-based study (2012–2021) Open
The rate of HDP has risen across Canada, with a concomitant decline in some HDP-associated morbidities. Ongoing surveillance of HDP is needed to assess the factors associated with temporal trends, including the effectiveness of evolving HD…
View article: Outlier analysis for accelerating clinical discovery: An augmented intelligence framework and a systematic review
Outlier analysis for accelerating clinical discovery: An augmented intelligence framework and a systematic review Open
Clinical discoveries largely depend on dedicated clinicians and scientists to identify and pursue unique and unusual clinical encounters with patients and communicate these through case reports and case series. This process has remained es…
View article: Diabetes mellitus in pregnancy across Canada
Diabetes mellitus in pregnancy across Canada Open
Background Contemporary estimates of diabetes mellitus (DM) rates in pregnancy are lacking in Canada. Accordingly, this study examined trends in the rates of type 1 (T1DM), type 2 (T2DM) and gestational (GDM) DM in Canada over a 15-year pe…
View article: Postpartum Emergency Department Use Following Midwifery-Model vs Obstetrics-Model Care
Postpartum Emergency Department Use Following Midwifery-Model vs Obstetrics-Model Care Open
Importance Emergency department (ED) use postpartum is a common and often-preventable event. Unlike traditional obstetrics models, the Ontario midwifery model offers early care postpartum. Objective To assess whether postpartum ED use diff…
View article: Mental Illness in the 2 Years Prior to Pregnancy in a Population With Traumatic Brain Injury: A Cross-Sectional Study: La maladie mentale dans les deux ans précédant une grossesse dans une population souffrant de lésion cérébrale traumatique : une étude transversale
Mental Illness in the 2 Years Prior to Pregnancy in a Population With Traumatic Brain Injury: A Cross-Sectional Study: La maladie mentale dans les deux ans précédant une grossesse dans une population souffrant de lésion cérébrale traumatique : une étude transversale Open
Objective Existing studies, in mostly male samples such as veterans and athletes, show a strong association between traumatic brain injury (TBI) and mental illness. Yet, while an understanding of mental health before pregnancy is critical …
View article: Multifetal Pregnancy After Implementation of a Publicly Funded Fertility Program
Multifetal Pregnancy After Implementation of a Publicly Funded Fertility Program Open
Importance A publicly funded fertility program was introduced in Ontario, Canada, in 2015 to increase access to fertility treatment. For in vitro fertilization (IVF), the program mandated an elective single-embryo transfer (eSET) policy. H…
View article: Severe Maternal Morbidity and Mental Health Hospitalizations or Emergency Department Visits
Severe Maternal Morbidity and Mental Health Hospitalizations or Emergency Department Visits Open
Importance Severe maternal morbidity (SMM) can have long-term health consequences for the affected mother. The association between SMM and future maternal mental health conditions has not been well studied. Objective To assess the associat…
View article: Teen Pregnancy and Risk of Premature Mortality
Teen Pregnancy and Risk of Premature Mortality Open
Importance Unintentional injury, suicide, and homicide are leading causes of death among young females. Teen pregnancy may be a marker of adverse life experiences. Objective To evaluate the risk of premature mortality from 12 years of age …