J. Justin Gooding
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View article: Size‐Controlled Cobalt Nanoplates and Their Impact on Oxygen Evolution Catalysis
Size‐Controlled Cobalt Nanoplates and Their Impact on Oxygen Evolution Catalysis Open
Controlling the size of nanoparticles is important in catalytic reactions, not only for tuning the surface area but also for modifying the electronic structure. However, achieving precise size control in 2D structures remains challenging. …
View article: High-throughput 3D engineered paediatric tumour models for precision medicine
High-throughput 3D engineered paediatric tumour models for precision medicine Open
Precision medicine for paediatric and adult cancers that incorporates drug sensitivity profiling can identify effective therapies for individual patients. However, obtaining adequate biopsy samples for high-throughput (HTP) screening remai…
View article: A biofabricated 3D cancer-stroma tumor microenvironment model
A biofabricated 3D cancer-stroma tumor microenvironment model Open
Breast cancer progression is a consequence of intricate dynamics between cells and their matrix in the tumor microenvironment. However, most in vitro models are not amenable to studying the behavior of multiple cell types within a defined …
View article: How the Arrangement of Platinum Atoms on Ruthenium Nanoparticles Improves Hydrogen Evolution Activity
How the Arrangement of Platinum Atoms on Ruthenium Nanoparticles Improves Hydrogen Evolution Activity Open
The platinum‐ruthenium (PtRu) system is highly active for hydrogen evolution reaction (HER) in alkaline media with both Pt and Ru playing active roles in the water dissociation step that generates adsorbed hydrogen atoms. Precise control o…
View article: Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface
Interfacial Stress Regulates Plasticity and Drug Resistance at the Breast Cancer‐Host Interface Open
The confinement of breast cancer cells at the interface of the mammary gland lumen and its surrounding extracellular matrix is thought to be a key physical driver of cellular plasticity. The relationship between confinement‐induced solid s…
View article: Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications
Decoding Hydrogel Porosity: Advancing the Structural Analysis of Hydrogels for Biomedical Applications Open
Hydrogels are essential biomaterials for biomedical applications, valued for their tunable properties and biocompatibility. A key feature influencing their function is porosity, which governs transport properties. Cryogenic scanning electr…
View article: P3ANUT: An enhanced DNA sequencing analysis platform for uncovering and correcting errors in peptide display library screening
P3ANUT: An enhanced DNA sequencing analysis platform for uncovering and correcting errors in peptide display library screening Open
Display technologies are used extensively in the discovery of peptides and antibodies towards the development of new medicines and diagnostic tools. Phage display technology enables the filtering of <10 10 random peptides/antibodies down t…
View article: Electrochemical fluorescence modulation enables simultaneous multicolour imaging
Electrochemical fluorescence modulation enables simultaneous multicolour imaging Open
Multicolour fluorescence imaging is crucial to simultaneously visualize multiple targets in cells, enabling the study of complicated cellular processes. Common multicolour methods rely on using fluorophores with sufficiently different spec…
View article: Iridium Nanocrystals Enriched with Defects and Atomic Steps to Enhance Oxygen Evolution Reaction Performance
Iridium Nanocrystals Enriched with Defects and Atomic Steps to Enhance Oxygen Evolution Reaction Performance Open
The presence of defects can significantly improve catalytic activity and stability, as they influence the binding of the reactants, intermediates, and products to the catalyst. Controlling defects in the structures of nanocrystal catalysts…
View article: AI-Empowered Catalyst Discovery: A Survey from Classical Machine Learning Approaches to Large Language Models
AI-Empowered Catalyst Discovery: A Survey from Classical Machine Learning Approaches to Large Language Models Open
Catalysts are essential for accelerating chemical reactions and enhancing selectivity, which is crucial for the sustainable production of energy, materials, and bioactive compounds. Catalyst discovery is fundamental yet challenging in comp…
View article: Direct detection of microRNA in liquid biopsies from single cancer spheroids
Direct detection of microRNA in liquid biopsies from single cancer spheroids Open
The biosensing platform detected miRNA-155 from a single breast cancer spheroid and enabled dynamic tracking of its level changes after anti-cancer treatment, showing the potential to help oncologists develop more personalized treatment st…
View article: Formation of open ruthenium branched structures with highly exposed active sites for oxygen evolution reaction electrocatalysis
Formation of open ruthenium branched structures with highly exposed active sites for oxygen evolution reaction electrocatalysis Open
The open Ru branched nanostructures provide high accessibility to incoming reagents and high electrochemically active surface areas for catalysing the oxygen evolution reaction.
View article: An investigative study of electrochemical induced fluorescence for fluorophores
An investigative study of electrochemical induced fluorescence for fluorophores Open
Understanding and controlling the fluorescence of dye molecules is essential for many applications especially in biological imaging.
View article: pH‐Dependant Electrochemical Oxidation of Small Molecules on Glassy Carbon, Platinum and Gold
pH‐Dependant Electrochemical Oxidation of Small Molecules on Glassy Carbon, Platinum and Gold Open
Composite electrodes often consisting of a purportedly inactive support material modified with a variety of nanomaterials, surface chemistry and coatings are commonly employed as electroanalytical devices for detection of biologically rele…
View article: A nanozyme that can go beyond an enzyme: the selective detection of two species in the same whole blood sample
A nanozyme that can go beyond an enzyme: the selective detection of two species in the same whole blood sample Open
The selective detection of two analytes was achieved by utilizing nanoparticles with isolated substrate channels, inspired by enzymes, and electrochemical potential to alter the local solution to facilitate either reaction.
View article: How octopod Mn–Fe oxide nanoparticle tracers minimize relaxation time and enhance MPI resolution
How octopod Mn–Fe oxide nanoparticle tracers minimize relaxation time and enhance MPI resolution Open
25 nm Octopod Mn–Fe oxide nanoparticles reduce crystal anisotropy, leading to faster relaxation times, a narrower MPI point spread function (PSF), and consequently improved spatial resolution.
View article: Preparation of electrochemical aptamer-based sensors: a direct aryl diazonium grafting approach
Preparation of electrochemical aptamer-based sensors: a direct aryl diazonium grafting approach Open
Electrochemical aptamer-based (EAB) sensors represent a promising platform for continuous monitoring of various of biomarkers due to the unique properties of aptamers, such as high affinity, target binding reversibility and their facile de…
View article: Patient-Specific Circulating Tumor DNA for Monitoring Response to Menin Inhibitor Treatment in Preclinical Models of Infant Leukemia
Patient-Specific Circulating Tumor DNA for Monitoring Response to Menin Inhibitor Treatment in Preclinical Models of Infant Leukemia Open
Background: In infant KMT2A (MLL1)-rearranged (MLL-r) acute lymphoblastic leukemia (ALL), early relapse and treatment response are currently monitored through invasive repeated bone marrow (BM) biopsies. Circulating tumor DNA (ctDNA) in pe…
View article: Engineered paediatric tumours retain maintains tumour genotype and phenotype for precision medicine
Engineered paediatric tumours retain maintains tumour genotype and phenotype for precision medicine Open
Precision medicine for paediatric and adult cancers that includes drug sensitivity profiling, can identify effective therapies for individual patients. However, obtaining adequate biopsy samples for high-throughput (HTP) screening remains …
View article: Polyethylene Glycol‐Based Hydrogel as a <scp>3D</scp> Extracellular Matrix Mimic for Cytotoxic T Lymphocytes
Polyethylene Glycol‐Based Hydrogel as a <span>3D</span> Extracellular Matrix Mimic for Cytotoxic T Lymphocytes Open
Three‐dimensional (3D) in vitro models enable us to understand cell behavior that is a better reflection of what occurs in vivo than 2D in vitro models. As a result, developing 3D models for extracellular matrix (ECM) has been growing expo…
View article: Guitar Pickups I: Analysis of the Effect of Winding and Wire Gauge on Single Coil Electric Guitar Pickups
Guitar Pickups I: Analysis of the Effect of Winding and Wire Gauge on Single Coil Electric Guitar Pickups Open
Guitar Pickups have been in production for nearly 100 years, and the question of how exactly one pickup is tonally superior to another is still subject to a high level of debate. This paper is the first in a set demystifying the production…
View article: Self-assembled monolayers: a journey from fundamental tools for understanding interfaces to commercial sensing technologies
Self-assembled monolayers: a journey from fundamental tools for understanding interfaces to commercial sensing technologies Open
Self-assembled monolayers were first described in the 1980s and have now become ubiquitous in many interfacial technologies. In this account, we discuss different self-assembled monolayer systems, outlining their positives and negatives. W…
View article: How Size and Composition of Cobalt Doped Iron Oxide Nanoparticle Tracers Enhance Magnetic Particle Imaging Performance
How Size and Composition of Cobalt Doped Iron Oxide Nanoparticle Tracers Enhance Magnetic Particle Imaging Performance Open
Magnetic particle imaging (MPI) is a promising diagnostic imaging technique that enables direct and precise tracking of magnetic tracers. The optimization of iron oxide-based nanoparticle tracers is of utmost importance in MPI for attainin…
View article: Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry
Advancing Synthetic Hydrogels through Nature‐Inspired Materials Chemistry Open
Synthetic extracellular matrix (ECM) mimics that can recapitulate the complex biochemical and mechanical nature of native tissues are needed for advanced models of development and disease. Biomedical research has heavily relied on the use …
View article: Challenges and Opportunities for Single‐Atom Electrocatalysts: From Lab‐Scale Research to Potential Industry‐Level Applications
Challenges and Opportunities for Single‐Atom Electrocatalysts: From Lab‐Scale Research to Potential Industry‐Level Applications Open
Single‐atom electrocatalysts (SACs) are a class of promising materials for driving electrochemical energy conversion reactions due to their intrinsic advantages, including maximum metal utilization, well‐defined active structures, and stro…
View article: Electrochemically controlled switching of dyes for enhanced super-resolution optical fluctuation imaging (SOFI)
Electrochemically controlled switching of dyes for enhanced super-resolution optical fluctuation imaging (SOFI) Open
In super-resolution optical fluctuation imaging (SOFI), the locations of molecules spaced closer than the diffraction limit of light can be identified through spatial and temporal correlation analysis of the fluorescence intensity fluctuat…