J. Gordon Boyd
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View article: Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria
Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria Open
Importance Accurate and timely confirmation of death by neurologic criteria (DNC) is essential for clinical decision-making and organ-donation processes, yet currently available ancillary tests have suboptimal diagnostic performance or lim…
View article: Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review
Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review Open
View article: Microbiology and long-term outcomes in community-acquired, nosocomial and post-neurosurgical meningitis with positive bacterial culture in Ontario, Canada: A population-based cohort study
Microbiology and long-term outcomes in community-acquired, nosocomial and post-neurosurgical meningitis with positive bacterial culture in Ontario, Canada: A population-based cohort study Open
View article: Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial
Impact of Antibiotic Duration on Gut Microbiome Composition and Antimicrobial Resistance: A Substudy of the BALANCE Randomized Controlled Trial Open
Background Maintaining a diverse gut microbiome and minimizing antimicrobial resistance gene (ARG) carriage through reduced antibiotic utilization may decrease antimicrobial resistance. We compared gut microbiome disruption and ARG carriag…
View article: IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers
IMPACT-ICU feasibility study: pragmatic mixed-methods randomised controlled trial of a follow-up care intervention for survivors of critical illness and caregivers Open
Introduction Survivors of critical illness and their caregivers are at risk for long-term cognitive, physical and psychiatric impairments known as post-intensive care syndrome (PICS) and PICS-family, respectively. This study will assess th…
View article: Long-term morbidity and mortality of patients who survived past 30 days from bloodstream infection: A population-based retrospective cohort study
Long-term morbidity and mortality of patients who survived past 30 days from bloodstream infection: A population-based retrospective cohort study Open
BSI survivors have substantial long-term mortality and morbidity including stroke, MI, new start dialysis and functional decline leading to LTC admission.
View article: Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial
Effects of Losartan on Patients Hospitalized for Acute COVID-19: A Randomized Controlled Trial Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) down-regulates angiotensin-converting enzyme 2, potentially increasing angiotensin II. We hypothesized that losartan compared to usual care decreases mortality and is …
View article: Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial
Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial Open
Introduction Most solid organ transplants originate from donors meeting criteria for death by neurological criteria (DNC). Within the organ donor, physiological responses to brain death increase the risk of ischaemia reperfusion injury and…
View article: Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study
Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study Open
Frailty severity was dynamic, can be measured during recovery from critical illness using the CFS and FI which were both associated with worse outcomes. Although the CFS is a global measure, a CGA FI based may have advantages of being able…
View article: WCN24-5 Feasibility study evaluating neurological impairment in critically ill dialysis patients
WCN24-5 Feasibility study evaluating neurological impairment in critically ill dialysis patients Open
Acute kidney injury (AKI) resulting in kidney replacement therapy (KRT) is rising among critically ill adults. Long-term KRT and critical illness are independently linked to acute (i.e., delirium) and prolonged cognitive impairment and str…
View article: Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL) Open
After the publication of the article, we have been informed that the name of a contributor in the list of REVIVAL investigators was given incomplete. He was given as “Patrick Honore” or “Honore P” but he should have been cited as “Patrick …
View article: Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia
Using a targeted metabolomics approach to explore differences in ARDS associated with COVID-19 compared to ARDS caused by H1N1 influenza and bacterial pneumonia Open
View article: Ceragenin-coated endotracheal tubes for the reduction of ventilator-associated pneumonia: a prospective, longitudinal, cross-over, interrupted time, implementation study protocol (CEASE VAP study)
Ceragenin-coated endotracheal tubes for the reduction of ventilator-associated pneumonia: a prospective, longitudinal, cross-over, interrupted time, implementation study protocol (CEASE VAP study) Open
Background Critically ill patients are at high risk of acquiring ventilator-associated pneumonia (VAP), which occurs in approximately 20% of mechanically ventilated patients. VAP results either from aspiration of pathogen-contaminated orop…
View article: Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study
Nebulized Furosemide for Pulmonary Inflammation in Intubated Patients With COVID-19: A Phase 2 Randomized Controlled Double-Blind Study Open
OBJECTIVES: Respiratory failure secondary to COVID-19 is associated with morbidity and mortality. Current anti-inflammatory therapies are effective but are given systemically and have significant side effects. Furosemide has anti-inflammat…
View article: Exploration of the association between inflammatory cytokines and development of new-onset atrial fibrillation in critically ill patients: a retrospective cohort study
Exploration of the association between inflammatory cytokines and development of new-onset atrial fibrillation in critically ill patients: a retrospective cohort study Open
BackgroundNew-onset atrial fibrillation (new AF) in critically ill patients is associated with increased morbidity and mortality. There has been evidence linking atrial fibrillation with inflammation in both the setting of chronic atrial f…
View article: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)
Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL) Open
Among critically ill patients with SA-AKI, ilofotase alfa did not improve day 28 survival. There may, however, be reduced MAKE90 events. No safety concerns were identified.
View article: Non–ECG-gated cardiac CT angiography in acute stroke is feasible and detects sources of embolism
Non–ECG-gated cardiac CT angiography in acute stroke is feasible and detects sources of embolism Open
Background: A significant portion of cryptogenic stroke is hypothesized to be secondary to cardiac embolism. However, transthoracic echocardiogram is usually delayed after stroke, and more detailed cardiac imaging is not routinely done. Ai…
View article: Feasibility and Cost Analysis of Portable MRI Implementation in a Remote Setting in Canada
Feasibility and Cost Analysis of Portable MRI Implementation in a Remote Setting in Canada Open
Objective: To conduct feasibility and cost analysis of portable MRI implementation in a remote setting where MRI access is otherwise unavailable. Methods: Portable MRI (ultra-low field, 0.064T) was installed in Weeneebayko General Hospital…
View article: Importance of Reconnection With ICU Survivors to ICU Recovery Program Clinicians
Importance of Reconnection With ICU Survivors to ICU Recovery Program Clinicians Open
Presently, ICU recovery care has appropriately focused on ICU survivor and caregiver outcomes. The provision of ICU recovery services through specialized post-ICU programs are one approach clinicians and researchers have focused their effo…
View article: Psychophysiological models of hypovigilance detection: A scoping review
Psychophysiological models of hypovigilance detection: A scoping review Open
Hypovigilance represents a major contributor to accidents. In operational contexts, the burden of monitoring/managing vigilance often rests on operators. Recent advances in sensing technologies allow for the development of psychophysiology…
View article: Establishing the role of the FES tyrosine kinase in the pathogenesis, pathophysiology, and severity of sepsis and its outcomes
Establishing the role of the FES tyrosine kinase in the pathogenesis, pathophysiology, and severity of sepsis and its outcomes Open
Introduction Sepsis is a result of initial over-activation of the immune system in response to an infection or trauma that results in reduced blood flow and life-threatening end-organ damage, followed by suppression of the immune system th…
View article: Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures
Neurologic Physiology after Removal of Therapy (NeuPaRT) study: study protocol of a multicentre, prospective, observational, pilot feasibility study of neurophysiology after withdrawal of life-sustaining measures Open
Introduction In donation after circulatory determination of death, death is declared 5 min after circulatory arrest. This practice assumes, but does not explicitly confirm, permanent loss of brain activity. While this assumption is rooted …
View article: Neurological Impairment in Critically Ill Patients on Dialysis: Research Letter for the INCOGNITO-AKI Feasibility Study
Neurological Impairment in Critically Ill Patients on Dialysis: Research Letter for the INCOGNITO-AKI Feasibility Study Open
Background: Acute kidney injury (AKI) resulting in kidney replacement therapy is rising among critically ill adults. Long-term kidney replacement therapy and critical illness are independently linked to acute and prolonged cognitive impair…
View article: Optimized Arterial Line Artifact Identification Algorithm Cleans High-Frequency Arterial Line Data With High Accuracy in Critically Ill Patients
Optimized Arterial Line Artifact Identification Algorithm Cleans High-Frequency Arterial Line Data With High Accuracy in Critically Ill Patients Open
OBJECTIVES: High-frequency data streams of vital signs may be used to generate individualized hemodynamic targets for critically ill patients. Central to this precision medicine approach to resuscitation is our ability to screen these data…
View article: Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol
Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol Open
Introduction Traumatic brain injury (TBI) is the leading cause of mortality and long-term disability in young adults. Despite the high prevalence of anaemia and red blood cell transfusion in patients with TBI, the optimal haemoglobin (Hb) …
View article: Outcomes of critically ill COVID-19 survivors and caregivers: a case study-centred narrative review
Outcomes of critically ill COVID-19 survivors and caregivers: a case study-centred narrative review Open
View article: Facteurs qui influent sur le consentement au don d’organes : étude rétrospective basée dans la population
Facteurs qui influent sur le consentement au don d’organes : étude rétrospective basée dans la population Open
CONTEXTE: Améliorer l’approche des donneurs d’organes potentiels et obtenir leur consentement pourrait favoriser l’autonomie des patients et donner accès à un plus grand nombre d’organes à transplanter. Nous avons voulu identifier les fact…
View article: Visuospatial and Executive Dysfunction in Patients With Acute Kidney Injury, Chronic Kidney Disease, and Kidney Failure: A Multilevel Modeling Analysis
Visuospatial and Executive Dysfunction in Patients With Acute Kidney Injury, Chronic Kidney Disease, and Kidney Failure: A Multilevel Modeling Analysis Open
Background: Neurocognitive impairment is a common finding across the spectrum of kidney disease and carries important consequences for quality of life. We previously demonstrated that robotic technology can identify neurocognitive impairme…
View article: Quantifying neurological function in patients undergoing transcatheter aortic valve implantation
Quantifying neurological function in patients undergoing transcatheter aortic valve implantation Open
This study captures the variability in neurological functioning in older patients undergoing TAVI. Robotic technology and quantified assessment procedures can be extremely valuable for detecting perioperative neurological impairments in th…
View article: Factors associated with consent for organ donation: a retrospective population-based study
Factors associated with consent for organ donation: a retrospective population-based study Open
BACKGROUND: Optimizing the approach to and consent of potential organ donors maximizes patient autonomy and the availability of organs for transplants. We set out to identify modifiable factors associated with donation consent. METHODS: We…