John A. Goss
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View article: Factors Influencing 25‐Year Survival in Pediatric Liver Transplant Recipients
Factors Influencing 25‐Year Survival in Pediatric Liver Transplant Recipients Open
Background This study assesses the impact of cholestatic liver disease, including biliary atresia, on 25‐year survival post‐transplantation and additional factors influencing long‐term outcomes after pediatric liver transplantation. Method…
View article: Liver Transplantation in 3 Cholestatic Infants With History of COVID Exposure
Liver Transplantation in 3 Cholestatic Infants With History of COVID Exposure Open
The COVID-19 pandemic presents several challenges during pregnancy including thromboembolic complications, direct placental infection, transplacental transmission, and systemic hyperinflammatory state. The liver is the second most commonly…
View article: Asynchronous Transitions from High-Risk Hepatoblastoma to Carcinoma
Asynchronous Transitions from High-Risk Hepatoblastoma to Carcinoma Open
Background Pediatric hepatocellular tumors are most commonly classified as hepatoblastoma (HB) or hepatocellular carcinoma (HCC), yet a subset exhibits mixed histological and molecular features of both. These tumors, previously described a…
View article: Healthcare Worker Attitudes to Living Donation Prior to Planned Withdrawal of Care
Healthcare Worker Attitudes to Living Donation Prior to Planned Withdrawal of Care Open
Background and Aims: This study assesses the attitudes of healthcare practitioners toward Living Donation Prior to Planned Withdrawal of Care (LD-PPW): the recovery of a living donor organ before withdrawal of life-sustaining measures in a…
View article: Severe febrile neutropenia and pancytopenia in a patient with advanced hepatocellular carcinoma treated with atezolizumab and bevacizumab: a case report
Severe febrile neutropenia and pancytopenia in a patient with advanced hepatocellular carcinoma treated with atezolizumab and bevacizumab: a case report Open
In conclusion, we observed temporary severe febrile neutropenia and pancytopenia during systemic immunotherapy in a patient with unresectable HCC. Healthcare providers should consider hematological irAEs (hem-irAEs) in patients after the a…
Trends in Survival for Adult Organ Transplantation Open
Objective: Intent-to-treat analysis follows patients from listing to death, regardless of their transplant status, and aims to provide a more holistic scope of the progress made in adult solid-organ transplantation. Background: Many studie…
View article: Genome-wide association study identifies high-impact susceptibility loci for HCC in North America
Genome-wide association study identifies high-impact susceptibility loci for HCC in North America Open
Background and Aims: Despite the substantial impact of environmental factors, individuals with a family history of liver cancer have an increased risk for HCC. However, genetic factors have not been studied systematically by genome-wide ap…
View article: A Surgical Collaborative to Empower Medical Student Research
A Surgical Collaborative to Empower Medical Student Research Open
Mini abstracts: Faculty at the Baylor College of Medicine have developed a flexible research collaborative through which students gain research skills and individualized mentorship. This division has produced 86 trainee first author public…
View article: Stevens–Johnson syndrome/toxic epidermal necrolysis in an orthotopic liver transplant recipient: a case report
Stevens–Johnson syndrome/toxic epidermal necrolysis in an orthotopic liver transplant recipient: a case report Open
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare spectrum of acute, mucocutaneous drug reactions characterized by epidermal necrosis of the skin and mucous membranes with progressive multiorgan failure. Cutaneous pre…
Clinical utility of plasma microbial cell-free DNA sequencing in determining microbiologic etiology of infectious syndromes in solid organ transplant recipients Open
Background: Metagenomic next-generation sequencing (mNGS) is increasingly being used for microbial detection in various infectious syndromes. However, data regarding the use of mNGS in solid organ transplant recipients (SOTR) are lacking. …
Retrospective Analysis of the Impact of High- and Low-Quality Donor Livers for Patients with High-Acuity Illness Open
BACKGROUND Patients with high-acuity liver failure have increased access to marginal and split liver options, owing to historically high waitlist mortality rates. While most research states that donor liver quality has no impact on patient…
View article: Estimating risk of prolonged mechanical ventilation after liver transplantation in children: <scp>PROVE‐ALT</scp> score
Estimating risk of prolonged mechanical ventilation after liver transplantation in children: <span>PROVE‐ALT</span> score Open
Background Children at high risk for prolonged mechanical ventilation (PMV) after liver transplantation (LT) need to be identified early to optimize pulmonary support, allocate resources, and improve surgical outcomes. We aimed to develop …
<span>Radiological‐histopathological</span> discordance in patients transplanted for <span>HCC</span> and its impact on post‐transplant outcomes Open
Background and Aims Contrast‐enhanced cross‐sectional imaging is the cornerstone in the diagnosis, staging, and management of HCC, including eligibility for liver transplantation (LT). Radiological‐histopathological discordance may lead to…
View article: Pediatric Acute Liver Failure Secondary to Autoimmune Hepatitis in an Infant With Thrombocytopenia‐Absent Radius (TAR) Syndrome
Pediatric Acute Liver Failure Secondary to Autoimmune Hepatitis in an Infant With Thrombocytopenia‐Absent Radius (TAR) Syndrome Open
Thrombocytopenia absent radius (TAR) syndrome is a rare genetic disorder that has been associated with food protein–induced allergic proctocolitis and transient leukemoid reactions, among other manifestations. There has been no prior repor…
Twenty-year survival following lung transplantation Open
This is the first study identifying factors associated with multiple-decade survival following lung transplant in the United States. Despite its challenges, long-term survival is possible and more likely in younger females in good waitlist…
View article: Selecting DCD Recipients Using Predictive Indices
Selecting DCD Recipients Using Predictive Indices Open
Background. Donation after circulatory death (DCD) allografts might represent one of the largest untapped sources of liver allografts. Our aim was to identify independent recipient risk factors that predict mortality in DCD allograft recip…
Disparate Intent-to-Treat Outcomes for Pediatric Liver Transplantation Based on Indication Open
Background. The impact of indication for pediatric liver transplantation on waitlist and post-transplant mortality outcomes is well known, but the impact on intent-to-treat outcomes has not been investigated. Intent-to-treat survival analy…
Liver Explants of Biliary Atresia Patients Transplanted in Adulthood Show Features of Obliterative Portal Venopathy: Case Series and Guidelines for Pathologic Reporting of Adult Explants Open
Context.— Biliary atresia (BA) patients can have portal vein (PV) abnormalities. Objective.— To investigate the explant pathology of BA patients transplanted in adulthood with a focus on portal venous abnormalities. Design.— Adult BA liver…
View article: A new chapter in an evolving pandemic: Successful pediatric liver transplantation with <scp>SARS‐CoV</scp>‐2+ donors
A new chapter in an evolving pandemic: Successful pediatric liver transplantation with <span>SARS‐CoV</span>‐2+ donors Open
Background Amid a viral pandemic with poorly understood transmissibility and pathogenicity in the pediatric patient, we report the first pediatric liver transplants utilizing allografts from SARS‐CoV‐2+ donors. Methods We describe the outc…
View article: Recipient Age Predicts 20-Year Survival in Pediatric Liver Transplant
Recipient Age Predicts 20-Year Survival in Pediatric Liver Transplant Open
Introduction. Pediatric liver transplant recipients have demonstrated excellent long-term survival. The purpose of this analysis is to investigate factors associated with 20-year survival to identify areas for improvement in patient care. …
Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplant Open
Four organ transplant recipients from an organ donor diagnosed with anaplastic pleomorphic xanthoastrocytoma developed fatal malignancies for which the origin could not be confirmed by standard methods. We identified the somatic mutational…
View article: Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults
Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults Open
Malignant hepatocellular cancers are the most common primary liver malignancies in children, and hepatoblastomas (HBs) account for more than two-thirds of these cases. While most HBs respond to chemotherapy and have favorable outcomes, the…
View article: Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults
Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults Open
Malignant hepatocellular cancers are the most common primary liver malignancies in children, and hepatoblastomas (HBs) account for more than two-thirds of these cases. While most HBs respond to chemotherapy and have favorable outcomes, the…
View article: Splenic Artery Transposition for Liver Transplantation: An Underutilized Technique?
Splenic Artery Transposition for Liver Transplantation: An Underutilized Technique? Open
Background. Successful liver transplantation is dependent on restoration of hepatic arterial (HA) flow. Although uncommon, some native recipient HAs are not suitable or inadequate for anastomosis, thereby necessitating extra-anatomic HA re…