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View article: Quality evaluation of synthetic CT using a gamma analysis for prostate cancer MR-only radiotherapy
Quality evaluation of synthetic CT using a gamma analysis for prostate cancer MR-only radiotherapy Open
Aplication effectively evaluates sCT quality, supporting the feasibility of MR-only radiotherapy. By providing detailed HU comparisons, the tool enhances MR-based treatment planning, reducing costs and ionizing radiation exposure. Its impl…
View article: Cardiac doses with deep inspiration breath hold in breast cancer radiotherapy: direct comparison between WBI, PBI, and interstitial APBI
Cardiac doses with deep inspiration breath hold in breast cancer radiotherapy: direct comparison between WBI, PBI, and interstitial APBI Open
The addition of DIBH significantly reduced EQD2 doses to all OARs (except for the left lung maximal dose) in WBI and PBI. MHD values were 0.72 Gy for DIBH-WBI, 1.01 Gy for MIB-APBI and 0.24 Gy for DIBH-PBI. There were no significant differ…
View article: High-Dose-Rate Brachytherapy as an Organ-Sparing Treatment for Early Penile Cancer
High-Dose-Rate Brachytherapy as an Organ-Sparing Treatment for Early Penile Cancer Open
Background: Low-dose-rate brachytherapy is an effective organ-sparing treatment for patients with early-stage penile cancer. However, only limited data are available on the role of high-dose-rate brachytherapy (HDR-BT) in this clinical set…
View article: Transcriptional Dynamics of DNA Damage Responsive Genes in Circulating Leukocytes during Radiotherapy
Transcriptional Dynamics of DNA Damage Responsive Genes in Circulating Leukocytes during Radiotherapy Open
External beam radiation therapy leads to cellular activation of the DNA damage response (DDR). DNA double-strand breaks (DSBs) activate the ATM/CHEK2/p53 pathway, inducing the transcription of stress genes. The dynamic nature of this trans…
View article: Total body irradiation for standard treatment rooms: a robust sweeping beam technique with respect to the body shape
Total body irradiation for standard treatment rooms: a robust sweeping beam technique with respect to the body shape Open
BACKGROUND: The purpose of this work is to improve a sweeping beam technique for total body irradiation (TBI) on a low flat couch using a varying patient thickness model. We designed a flat couch for total body irradiation in supine and pr…
View article: Cardiotoxicity of radiation therapy in esophageal cancer
Cardiotoxicity of radiation therapy in esophageal cancer Open
With a development of radiotherapeutic techniques, availability of radiotherapy data on cardiotoxicity, and slowly improving esophageal cancer outcomes, an increasing emphasis is placed on the heart protection in radiation treated esophage…
View article: Accelerated partial breast irradiation in elderly breast cancer patients
Accelerated partial breast irradiation in elderly breast cancer patients Open
Breast-conserving surgery with adjuvant whole-breast irradiation has become the standard treatment for early breast cancer (EBC) patients. Partial breast irradiation, which targets only the postoperative cavity, has been established as an …
View article: The Changes in Pharyngeal Constrictor Muscles Related to Head and Neck Radiotherapy: A Systematic Review
The Changes in Pharyngeal Constrictor Muscles Related to Head and Neck Radiotherapy: A Systematic Review Open
It is well known that radiation damage of the pharyngeal constrictor muscles, the glottic larynx, and the supraglottic larynx may lead to dysphagia, an unwanted effect of head and neck radiotherapy. The reduction of radiotherapy-induced dy…
View article: Validation of dose distribution computation on sCT images generated from MRI scans by Philips MRCAT
Validation of dose distribution computation on sCT images generated from MRI scans by Philips MRCAT Open
The dose calculation accuracy on MRCAT was not significantly compromised in the majority of clinical relevant DVH points. The introduction of MRCAT into practise would eliminate systematic errors, increase patients' comfort and reduce trea…
View article: High-Dose Rate Brachytherapy in the Treatment of Early Stages of Penile Carcinoma
High-Dose Rate Brachytherapy in the Treatment of Early Stages of Penile Carcinoma Open
Hyperfractionated interstitial high-dose rate brachyther-apy with 18 × 3 Gy per fraction twice daily is a promis-ing method in selected patients with penile carcinoma and deserves further evaluation in a larger prospective study. Key words…
View article: The first in vivo multiparametric comparison of different radiation exposure biomarkers in human blood
The first in vivo multiparametric comparison of different radiation exposure biomarkers in human blood Open
The increasing risk of acute large-scale radiological/nuclear exposures of population underlines the necessity of developing new, rapid and high throughput biodosimetric tools for estimation of received dose and initial triage. We aimed to…
View article: FDXR is a biomarker of radiation exposure in vivo
FDXR is a biomarker of radiation exposure in vivo Open
Previous investigations in gene expression changes in blood after radiation exposure have highlighted its potential to provide biomarkers of exposure. Here, FDXR transcriptional changes in blood were investigated in humans undergoing a ran…