Jakob Grove
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View article: Rare genetic variants confer a high risk of ADHD and implicate neuronal biology
Rare genetic variants confer a high risk of ADHD and implicate neuronal biology Open
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a large genetic component 1 . It affects around 5% of children and 2.5% of adults 2 , and is associated with several severe outcomes 3–11…
View article: Maternal body mass index in early pregnancy and autism in offspring: a population-based cohort study in Sweden and Denmark
Maternal body mass index in early pregnancy and autism in offspring: a population-based cohort study in Sweden and Denmark Open
Background Elevated maternal pre-pregnancy body mass index (BMI) has been suggested to increase risk of offspring autism spectrum disorder (ASD) but evidence is mixed across heterogeneous studies and robust estimates spanning the full BMI …
View article: Shared Genetic Architecture Between Endometriosis and Psychiatric Conditions May Explain Comorbidity
Shared Genetic Architecture Between Endometriosis and Psychiatric Conditions May Explain Comorbidity Open
Endometriosis is a common chronic gynecological disorder with complex and poorly understood etiology and no definitive cure. Beyond pain and infertility, affected individuals frequently experience psychiatric comorbidities, often attribute…
View article: Polygenic and developmental profiles of autism differ by age at diagnosis
Polygenic and developmental profiles of autism differ by age at diagnosis Open
Although autism has historically been conceptualized as a condition that emerges in early childhood 1,2 , many autistic people are diagnosed later in life 3–5 . It is unknown whether earlier- and later-diagnosed autism have different devel…
View article: Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa
Leveraging transdiagnostic genetic liability to psychiatric disorders to dissect clinical outcomes of anorexia nervosa Open
Anorexia nervosa (AN) has extensive genetic correlations with other psychiatric disorders, and genetic risk for different psychiatric disorders was associated with distinct clinical courses in AN. Uncovering associations between transdiagn…
View article: Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients
Multisite, Multiancestry Genome-Wide Association Study Meta-Analysis of Functional Seizure Disorder in a Hospital Sample of 675,680 Patients Open
To our knowledge, this is the first GWAS of FS, and our results support a genetic basis of FS. Future large-scale genetic research studies are needed to corroborate these findings and identify genetic variants associated with FS.
View article: Revisiting the Links Between Asthma and the Psychosis Spectrum: shared molecular mechanisms
Revisiting the Links Between Asthma and the Psychosis Spectrum: shared molecular mechanisms Open
Epidemiological studies suggest associations of asthma with the psychosis spectrum (psychotic experiences, bipolar disorder, schizophrenia), but the mechanisms underlying these associations remain unclear. We examined the relationship betw…
View article: Functional consequences of genetic risk for neuropsychiatric conditions at chr22q
Functional consequences of genetic risk for neuropsychiatric conditions at chr22q Open
Understanding how common and rare genetic variation raises risk for neuropsychiatric disease remains a major challenge. We identify the long arm of chromosome 22 (chr22q) as a region where common polygenic risk for schizophrenia, autism, A…
View article: Cross-setting replication of the associations between maternal health and autism
Cross-setting replication of the associations between maternal health and autism Open
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition with early-life origins. Maternal health conditions during pregnancy have been linked to autism risk, but most studies focus on single populations, limiting genera…
View article: GWAS of macro-scale resting state functional brain networks identify shared biology with brain structure and autism
GWAS of macro-scale resting state functional brain networks identify shared biology with brain structure and autism Open
The topology of the functional brain network has been associated with several neuropsychiatric conditions. However, little is known about its genetic underpinnings, and whether this overlaps with brain structure and neuropsychiatric condit…
View article: Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes
Genome-wide association studies of binge-eating behaviour and anorexia nervosa yield insights into the unique and shared biology of eating disorder phenotypes Open
Eating disorders—including anorexia nervosa (AN), bulimia nervosa, and binge eating disorder—are clinically distinct but exhibit symptom overlap and diagnostic crossover. Genomic analyses have mostly examined AN. We conducted the first gen…
View article: The Digital Health Competencies in Medical Education Framework
The Digital Health Competencies in Medical Education Framework Open
Importance Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field. Objective To de…
View article: Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology
Analysis of exonic deletions in a large population study provides novel insights into NRXN1 pathology Open
The NRXN1 locus is a hotspot for non-recurrent copy number variants and exon-disrupting NRXN1 deletions have been associated with increased risk of neurodevelopmental disorders in case-control studies. However, corresponding population-bas…
View article: The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder
The role of co-occurring conditions and genetics in the associations of eating disorders with attention-deficit/hyperactivity disorder and autism spectrum disorder Open
Eating disorders (EDs) commonly co-occur with other psychiatric and neurodevelopmental disorders including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD); however, the pattern of family history and genet…
View article: Common genetic variants are associated with increased likelihood of some co-occurring mental health conditions among autistic individuals
Common genetic variants are associated with increased likelihood of some co-occurring mental health conditions among autistic individuals Open
IMPORTANCE Autism frequently co-occurs with other mental health conditions. In the general population, these co-occurring mental health conditions are highly heritable and genetically correlated; however, the genetic architecture of co-occ…
View article: Polygenic and developmental profiles of autism differ by age at diagnosis
Polygenic and developmental profiles of autism differ by age at diagnosis Open
Although autism has been historically conceptualised as a condition that emerges in early childhood, many autistic people are diagnosed later in life. It is unknown whether earlier and later diagnosed autism have different developmental tr…
View article: Method for Testing Etiologic Heterogeneity Among Noncompeting Diagnoses, Applied to Impact of Perinatal Exposures on Autism and Attention Deficit Hyperactivity Disorder
Method for Testing Etiologic Heterogeneity Among Noncompeting Diagnoses, Applied to Impact of Perinatal Exposures on Autism and Attention Deficit Hyperactivity Disorder Open
Background: Testing etiologic heterogeneity, whether a disorder subtype is more or less impacted by a risk factor, is important for understanding causal pathways and optimizing statistical power. The study of mental health disorders especi…