John Strang
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View article: Drug use among people in prison: A global review of epidemiology, harms and interventions
Drug use among people in prison: A global review of epidemiology, harms and interventions Open
Background and aims People who use drugs are overrepresented in the criminal justice system. We aimed to provide a broad synthesis of the epidemiology, harms and interventions related to drug use and drug use disorders among incarcerated a…
View article: From fairytale to clinical practice: A response to commentaries
From fairytale to clinical practice: A response to commentaries Open
View article: Development of Novel Wearable Biosensor for Continuous Monitoring of Central Body Motion
Development of Novel Wearable Biosensor for Continuous Monitoring of Central Body Motion Open
Accidental opioid overdose and Sudden Unexpected Death in Epilepsy (SUDEP) represent major forms of preventable mortality, often involving sudden-onset catastrophic events that could be survivable with rapid detection and intervention. The…
View article: Recent Innovations to Detect and Intervene to Prevent Opioid Overdose Deaths
Recent Innovations to Detect and Intervene to Prevent Opioid Overdose Deaths Open
Opioid overdose deaths have become a rapidly growing global health crisis, with current estimates indicating over 125,000 deaths annually worldwide. This crisis has reached particularly high levels across North America, where the USA recor…
View article: Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms
Tapering and withdrawing opioids: guidance informed by fundamental principles to minimise withdrawal symptoms Open
Formal guidelines recommend that opioids should be stopped when risks outweigh benefits. These guidelines generally recommend gradual dose tapering at a rate tolerable to the patient. However, there is considerable variation regarding the …
View article: Analysis of rapid onset heroin overdose cases from a supervised injecting facility in Melbourne, Australia
Analysis of rapid onset heroin overdose cases from a supervised injecting facility in Melbourne, Australia Open
Aims To characterise the clinical condition of rapid onset heroin overdose cases, and to determine the incidence and characteristics of such cases. Design A retrospective cohort study of witnessed heroin overdose cases over a 12‐month peri…
View article: Employment and Long-Acting Injectable Buprenorphine for Opioid Use Disorder: Findings from Longitudinal Qualitative Interviews Conducted with Patients Recruited from Drug Treatment Services
Employment and Long-Acting Injectable Buprenorphine for Opioid Use Disorder: Findings from Longitudinal Qualitative Interviews Conducted with Patients Recruited from Drug Treatment Services Open
LAIB may help drug treatment patients who are interested in securing employment or achieving broader employment-related outcomes, such as education, training and volunteering. However, patients receiving LAIB may also need personalized emp…
View article: Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial
Does cannabidiol reduce the adverse effects of cannabis in schizophrenia? A randomised, double-blind, cross-over trial Open
In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment with cannabidiol (CBD) may reduce these effects, but other…
View article: A protocol for the evaluation of the PneumoWave biosensor in supported accommodation settings: A study on feasibility and acceptability (RESCU-2)
A protocol for the evaluation of the PneumoWave biosensor in supported accommodation settings: A study on feasibility and acceptability (RESCU-2) Open
Background People who overdose on opioids when they are alone or unmonitored are at heightened risk of death as other people do not know they should provide an emergency response. Wearable technology provides an opportunity to continuously…
View article: Prediction of individualised 6-month mortality risk in opioid use disorder
Prediction of individualised 6-month mortality risk in opioid use disorder Open
Background People with opioid use disorder (OUD) have substantially higher standardised mortality rates compared with the general population. However, lack of individualised prognostic information presents challenges in personalisation of …
View article: Non-prescribed ketamine use is rising in the UK
Non-prescribed ketamine use is rising in the UK Open
View article: Hydromorphone Hopes: A Qualitative Study of People Initiating Supervised Short‐Acting Injectable Opioid Treatment in Australia
Hydromorphone Hopes: A Qualitative Study of People Initiating Supervised Short‐Acting Injectable Opioid Treatment in Australia Open
Introduction A growing body of qualitative scholarship has drawn attention to aspects of supervised injectable opioid treatment (SIOT) not captured in earlier clinical trial data, identifying treatment initiation as one such area. Crucial …
View article: Mobile telephone-delivered Contingency Management (mCM) to reduce heroin use in individuals with opioid use disorder (CM4OUD): A feasibility study protocol
Mobile telephone-delivered Contingency Management (mCM) to reduce heroin use in individuals with opioid use disorder (CM4OUD): A feasibility study protocol Open
Background Opioid use disorder (OUD) is a major public health issue and recovery is a long-term and complex process. Opioid Agonist Treatment (OAT) including medications such as methadone and buprenorphine, is the first-line medical interv…
View article: Patient satisfaction with long-acting injectable buprenorphine: What needs to be measured from the patient’s perspective?
Patient satisfaction with long-acting injectable buprenorphine: What needs to be measured from the patient’s perspective? Open
Background
Long-acting injectable buprenorphine is an effective treatment for opioid use disorder. This paper asks: 1. How satisfied are people with long-acting injectable buprenorphine during their first year of treatment? 2. How do p…
Long-acting injectable buprenorphine is an effective treatment for opioid use disorder. This paper asks: 1. How satisfied are people with long-acting injectable buprenorphine during their first year of treatment? 2. How do p…
View article: Naloxone dosing by non-medical first-responders at opioid overdoses: findings from a qualitative interview study
Naloxone dosing by non-medical first-responders at opioid overdoses: findings from a qualitative interview study Open
Background Opioid-related deaths are increasing globally, and synthetic opioids intensify overdose risk. Naloxone can prevent fatalities, although too much can precipitate withdrawal and other negative reactions for the person overdosing. …
View article: Naloxone dosing in the era of synthetic opioids: Applying the Goldilocks principle
Naloxone dosing in the era of synthetic opioids: Applying the Goldilocks principle Open
The opioid overdose epidemic remains a critical public health crisis. In recent years, synthetic opioids like fentanyl and nitazenes, have driven a sharp rise in deaths. Naloxone, an opioid receptor antagonist, has been established as a ke…
View article: Mobile telephone contingency management to encourage adherence to supervised medication among individuals most at risk of non-adherence to opioid agonist treatment: a study protocol for a feasibility study (TIES2)
Mobile telephone contingency management to encourage adherence to supervised medication among individuals most at risk of non-adherence to opioid agonist treatment: a study protocol for a feasibility study (TIES2) Open
View article: Addiction specialists' perspectives on digital contingency management and its role within <scp>UK</scp> drug and alcohol services: A qualitative exploration
Addiction specialists' perspectives on digital contingency management and its role within <span>UK</span> drug and alcohol services: A qualitative exploration Open
Introduction Contingency management (CM), based on the principles of operant conditioning, uses positive reinforcement to promote behaviour change in individuals with substance use disorder. Research on CM has grown exponentially, with tec…
View article: Bridging the evidence and the politics: Implementation trial of supervised injectable opioid treatment (SIOT) in Australia
Bridging the evidence and the politics: Implementation trial of supervised injectable opioid treatment (SIOT) in Australia Open
View article: Understanding and reducing intimate partner violence perpetrated by men who misuse substances: the ADVANCE research programme
Understanding and reducing intimate partner violence perpetrated by men who misuse substances: the ADVANCE research programme Open
Background Despite the higher prevalence of intimate partner violence perpetration by men who misuse substances, the role of substance use in intimate partner violence is unclear. Evidence about what works to reduce intimate partner violen…
View article: High BMI is a specific risk factor for drug‐related mortality in patients receiving methadone: A case control study
High BMI is a specific risk factor for drug‐related mortality in patients receiving methadone: A case control study Open
Background and Aims Long‐term treatment of opioid dependence with the opioid agonist therapy (OAT) methadone can lead to significant weight gain. This study investigated whether OAT patients with a body mass index (BMI) deemed overweight (…
View article: A heroin overdose laboratory model: How do escalating doses of diamorphine alter respiratory function in a diamorphine‐treated population?
A heroin overdose laboratory model: How do escalating doses of diamorphine alter respiratory function in a diamorphine‐treated population? Open
Background & Aim Globally, more than 100 000 people die annually from opioid overdose. Although strongly implicated in heroin overdose deaths, acute opioid‐induced respiratory depression is poorly understood, and few laboratory studies hav…
View article: Long-Acting Injectable Buprenorphine for Opioid Use Disorder: A Qualitative Analysis of Patients’ Interpersonal Relationships during the First Year of Treatment
Long-Acting Injectable Buprenorphine for Opioid Use Disorder: A Qualitative Analysis of Patients’ Interpersonal Relationships during the First Year of Treatment Open
Introduction: Long-acting injectable buprenorphine (LAIB) is a new treatment for opioid use disorder. Drawing upon new materialism and the concept of social capital, this article provides a focused analysis of how LAIB affects, and …
View article: Research Priorities of Individuals and Families with Sex Chromosome Aneuploidies
Research Priorities of Individuals and Families with Sex Chromosome Aneuploidies Open
Sex chromosome aneuploidies (SCAs) are chromosomal variations that result from an atypical number of X and/or Y chromosomes. Combined, SCAs affect ~1/400 live births, including individuals with Klinefelter syndrome (47,XXY), Turner syndrom…
View article: Implementation of time-limited parenteral hydromorphone in people with treatment-resistant injecting opioid use disorder: a protocol for a single-site, uncontrolled, open-label study to assess feasibility, safety and cost
Implementation of time-limited parenteral hydromorphone in people with treatment-resistant injecting opioid use disorder: a protocol for a single-site, uncontrolled, open-label study to assess feasibility, safety and cost Open
Introduction Supervised injectable opioid treatment (SIOT) is an evidence-based intervention targeting opioid-dependent people for whom existing treatments have been ineffective. This project will primarily assess the feasibility and the a…
View article: Editorial: Changing addiction problems and care responses during and after a major crisis: emergence of a ‘new normal'
Editorial: Changing addiction problems and care responses during and after a major crisis: emergence of a ‘new normal' Open
Editorial: Changing addiction problems and care responses during and after a major crisis: emergence of a 'new normal'
View article: Overdose Detection Among High-Risk Opioid Users Via a Wearable Chest Sensor in a Supervised Injecting Facility: Protocol for an Observational Study
Overdose Detection Among High-Risk Opioid Users Via a Wearable Chest Sensor in a Supervised Injecting Facility: Protocol for an Observational Study Open
Background Opioid overdose is a global health crisis, affecting over 27 million individuals worldwide, with more than 100,000 drug overdose deaths in the United States in 2022-2023. This protocol outlines the development of the PneumoWave …
View article: The development and internal validation of a multivariable model predicting 6-month mortality for people with opioid use disorder presenting to community drug services in England: a protocol
The development and internal validation of a multivariable model predicting 6-month mortality for people with opioid use disorder presenting to community drug services in England: a protocol Open
View article: Clinical Pharmacokinetics and Pharmacodynamics of Naloxone
Clinical Pharmacokinetics and Pharmacodynamics of Naloxone Open
View article: Overdose Detection Among High-Risk Opioid Users Via a Wearable Chest Sensor in a Supervised Injecting Facility: Protocol for an Observational Study (Preprint)
Overdose Detection Among High-Risk Opioid Users Via a Wearable Chest Sensor in a Supervised Injecting Facility: Protocol for an Observational Study (Preprint) Open
BACKGROUND Opioid overdose is a global health crisis, affecting over 27 million individuals worldwide, with more than 100,000 drug overdose deaths in the United States in 2022-2023. This protocol outlines the development of the PneumoWave…