Julieta Gabriela Hamze
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View article: JUNO-Coated Beads as a Functional Assay to Capture and Characterize Fertilization-Competent Human Sperm
JUNO-Coated Beads as a Functional Assay to Capture and Characterize Fertilization-Competent Human Sperm Open
Study question Can human fertilization-competent spermatozoa be captured through their ability to bind the oocyte receptor JUNO? Summary answer JUNO-coated beads, which mimic the oocyte geometry, selectively bound acrosome-reacted spermato…
View article: P-077 Changes in the patterns of localisation of IZUMO1 protein in the human spermatozoa head during capacitation and acrosome reaction
P-077 Changes in the patterns of localisation of IZUMO1 protein in the human spermatozoa head during capacitation and acrosome reaction Open
Study question Is there any redistribution of IZUMO1 during the human sperm capacitation and acrosome reaction? Summary answer Using ultra-high-resolution microscopy techniques, we identified changes in the localisation pattern of IZUMO1 d…
View article: Navigating gene editing in porcine embryos: Methods, challenges, and future perspectives
Navigating gene editing in porcine embryos: Methods, challenges, and future perspectives Open
Gene editing technologies, particularly CRISPR/Cas9, have emerged as transformative tools in genetic modification, significantly advancing the use of porcine embryos in biomedical and agricultural research. This review comprehensively exam…
View article: <i>SMC2</i> ablation impairs bovine embryo development shortly after blastocyst hatching
<i>SMC2</i> ablation impairs bovine embryo development shortly after blastocyst hatching Open
In brief Bovine embryos lacking SMC2 (a core component of condensins I and II) are unable to survive maternal recognition of pregnancy. SMC2 KO embryos are able to form blastocysts, exhibiting a reduced cell proliferation ability, and arre…
View article: The role of TEAD4 in trophectoderm commitment and development is not conserved in non-rodent mammals
The role of TEAD4 in trophectoderm commitment and development is not conserved in non-rodent mammals Open
The first lineage differentiation in mammals gives rise to the inner cell mass and the trophectoderm (TE). In mice, TEAD4 is a master regulator of TE commitment, as it regulates the expression of other TE-specific genes and its ablation pr…
View article: HH5 double-carrier embryos fail to progress through early conceptus elongation
HH5 double-carrier embryos fail to progress through early conceptus elongation Open
Massive genotyping in cattle has uncovered several deleterious haplotypes that cause preterm mortality. Holstein haplotype 5 (HH5) is a deleterious haplotype present in the Holstein Friesian population that involves the ablation of the tra…
View article: Magnetic‐Assisted Control of Eggs and Embryos via Zona Pellucida‐Linked Nanoparticles
Magnetic‐Assisted Control of Eggs and Embryos via Zona Pellucida‐Linked Nanoparticles Open
Eggs and embryo manipulation is an important biotechnological challenge to enable positioning, entrapment, and selection of reproductive cells to advance into a new era of nature‐like assisted reproductive technologies. Oviductin (OVGP1) i…
View article: The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization
The Sperm Olfactory Receptor OLFR601 is Dispensable for Mouse Fertilization Open
Fertilization involves the fusion of two gametes by means of yet unknown membrane binding and fusion events. Over the last years, many sperm proteins have been uncovered to play essential roles in sperm-egg fusion in mammals, but their pre…
View article: Oolemma Receptors in Mammalian Molecular Fertilization: Function and New Methods of Study
Oolemma Receptors in Mammalian Molecular Fertilization: Function and New Methods of Study Open
Fertilization is a key process in biology to the extent that a new individual will be born from the fusion of two cells, one of which leaves the organism in which it was produced to exert its function within a different organism. The struc…
View article: Sperm binding to ZP2-coated beads improve the efficiency of porcine <i>in vitro</i> fertilisation
Sperm binding to ZP2-coated beads improve the efficiency of porcine <i>in vitro</i> fertilisation Open
The role of specific zona pellucida (ZP) glycoproteins in gamete interaction has not yet been elucidated in many species. A recently developed 3D model based on magnetic sepharose beads (B) conjugated to recombinant ZP glycoproteins (BZP) …
View article: TMEM95 is a sperm membrane protein essential for mammalian fertilization
TMEM95 is a sperm membrane protein essential for mammalian fertilization Open
The fusion of gamete membranes during fertilization is an essential process for sexual reproduction. Despite its importance, only three proteins are known to be indispensable for sperm-egg membrane fusion: the sperm proteins IZUMO1 and SPA…