Ji Hoe Heo
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Downstream Occlusion During Mechanical Thrombectomy: Clinical Implications and Endovascular Trajectory Open
Background/Objectives: Downstream occlusion (DOC) is a commonly observed, yet frequently overlooked, angiographic event during mechanical thrombectomy (MT) for acute large vessel occlusion (LVO). This phenomenon has the potential to compli…
Endovascular Thrombectomy in Cancer‐Related Stroke: Comparison of Thrombectomy Methods Open
BACKGROUND The optimal first‐line device choice for endovascular treatment (EVT) of cancer‐related stroke remains largely unknown. In this study, we evaluated the efficacy and safety of the EVT methods for treating cancer‐related stroke th…
View article: Thrombus composition and distribution patterns by thrombus volume in acute ischemic stroke
Thrombus composition and distribution patterns by thrombus volume in acute ischemic stroke Open
Background Thrombus burden considerably impacts ischemic stroke presentation and outcomes. However, the relationship between thrombus histology and volume has not been studied well. We investigated whether ischemic stroke thrombus composit…
Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial Open
Background and Purpose The Treat Stroke to Target (TST) was a randomized clinical trial involving French and Korean patients demonstrating that a lower low-density lipoprotein cholesterol (LDL-C, <70 mg/dL) target group (LT) experienced fe…
View article: Blood pressure management based on infarct volume after successful endovascular thrombectomy
Blood pressure management based on infarct volume after successful endovascular thrombectomy Open
Introduction: While the efficacy of endovascular thrombectomy (EVT) in large core infarcts has been established, the influence of blood pressure (BP) management on functional outcomes based on infarct volume remains unclear. Patients and m…
View article: Increased risk of recurrent stroke in patients with impaired kidney function: results of a pooled analysis of individual patient data from the MICON international collaboration
Increased risk of recurrent stroke in patients with impaired kidney function: results of a pooled analysis of individual patient data from the MICON international collaboration Open
Background Patients with chronic kidney disease are at increased risk of stroke and frequently have cerebral microbleeds. Whether such patients also encounter an increased risk of recurrent stroke has not been firmly established. We aimed …
View article: Mediation of Time‐Related Blood Pressure Variability on Intensive Blood Pressure Lowering and Functional Outcomes Post Endovascular Therapy: A Post Hoc Analysis of the OPTIMAL‐BP Trial
Mediation of Time‐Related Blood Pressure Variability on Intensive Blood Pressure Lowering and Functional Outcomes Post Endovascular Therapy: A Post Hoc Analysis of the OPTIMAL‐BP Trial Open
Background We investigated whether the association between blood pressure (BP) management in patients with successful reperfusion following endovascular therapy (EVT) and functional outcomes is mediated by BP variability parameters. Method…
View article: Association Between Estimated Pulse Wave Velocity and Endovascular Thrombectomy Outcome: A Secondary Analysis of the OPTIMAL‐BP Trial
Association Between Estimated Pulse Wave Velocity and Endovascular Thrombectomy Outcome: A Secondary Analysis of the OPTIMAL‐BP Trial Open
Background The link between arterial stiffness, measured by estimated pulse wave velocity (ePWV), and outcomes following endovascular thrombectomy (EVT) has not been tested. This study aimed to determine whether ePWV predicts post‐EVT outc…
Long-Term Outcome of Rescue Stenting for Acute Intracranial Atherosclerotic Stenosis–Related Large Vessel Occlusion in the Anterior Circulation Open
Patients with RS for ICAS-LVO showed a low stroke recurrence rate in the long-term. The long-term patency of RS appears to remain durable, particularly when it remained patent during the initial follow-up.
Risk of cardiovascular events following hemodialysis initiation: a self-controlled case series study Open
After HD initiation, the CVD risk increases in patients with CKD. For CVD prevention, the CVD risk should be carefully evaluated in patients with CKD who require HD.
Mild hypercapnia before reperfusion reduces ischemia-reperfusion injury in hyperacute ischemic stroke rat model Open
Endovascular thrombectomy has a recanalization rate over 80%; however, approximately 50% of ischemic stroke patients still experience dependency or mortality. Recently, clinical trials demonstrated the benefits of administering neuroprotec…
View article: Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds Open
Importance Cerebral small vessel disease (SVD) is associated with various cerebrovascular outcomes, but data on sex differences in SVD are scarce. Objective To investigate whether the frequency, severity, and distribution of cerebral micro…
Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation Open
Background: Protease-activated receptor 1 (PAR1) is expressed in human platelets and can be activated by low concentrations of thrombin. Vorapaxar, a selective antagonist of PAR1, inhibits thrombin-induced calcium mobilization in human pla…
Cancer-Associated Stroke: Thrombosis Mechanism, Diagnosis, Outcome, and Therapeutic Strategies Open
Cancer can induce hypercoagulability, which may lead to stroke. This occurs when tumor cells activate platelets as part of their growth and metastasis. Tumor cells activate platelets by generating thrombin and expressing tissue factor, res…
Ziziphus jujuba Miller Ethanol Extract Restores Disrupted Intestinal Barrier Function via Tight Junction Recovery and Reduces Inflammation Open
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by the disruption of the intestinal barrier. The intestinal barrier is maintained by tight junctions (TJs), which sustain intestinal homeostasis and prevent pathog…
View article: Functional Outcomes Associated With Blood Pressure Decrease After Endovascular Thrombectomy
Functional Outcomes Associated With Blood Pressure Decrease After Endovascular Thrombectomy Open
Importance The associations between blood pressure (BP) decreases induced by medication and functional outcomes in patients with successful endovascular thrombectomy remain uncertain. Objective To evaluate whether BP reductions induced by …
View article: Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds
Statin Therapy for Secondary Prevention in Ischemic Stroke Patients With Cerebral Microbleeds Open
This study provides Class III evidence that for patients with IS or TIA and CMBs, statins lower the risk of any stroke or IS without increasing the risk of ICrH.
Initial stroke severity and discharge outcome in patients with muscle mass deficit Open
This study aimed to investigate the association between muscle mass deficit and the initial severity of ischemic stroke. The impact of muscle mass deficit on the discharge outcome was also evaluated. This retrospective study included 660 p…
View article: Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA
Clinical Associations and Prognostic Value of MRI-Visible Perivascular Spaces in Patients With Ischemic Stroke or TIA Open
In patients with ischemic stroke or TIA, increasing BGPVS burden is associated with more severe cerebral small vessel disease and higher ischemic stroke risk. Neither BGPVS nor CSOPVS were independently associated with future ICH.
Association between substantia nigra degeneration and functional outcome in patients with basal ganglia infarction Open
Background and purpose Cerebral infarction in the basal ganglia may cause secondary and delayed neuronal degeneration in the substantia nigra (SN). However, the clinical significance of SN degeneration remains poorly understood. Methods Th…
Clinical Benefit of First-Pass Recanalization Is Time-Dependent in Endovascular Treatment of Acute Ischemic Stroke Open
Clinical benefit can be time-dependent even after first-pass recanalization (FPR) in endovascular treatment of acute stroke. This study aimed to evaluate the association between favorable outcome and FPR under a specific time frame. Patien…
Preprocedural D-Dimer Level as a Predictor of First-Pass Recanalization and Functional Outcome in Endovascular Treatment of Acute Ischemic Stroke Open
We aimed to evaluate the association between preprocedural D-dimer levels and endovascular and clinical outcomes. We retrospectively reviewed patients with acute intracranial large-vessel occlusion who underwent mechanical thrombectomy. Pl…
Patent Foramen Ovale May Decrease the Risk of Left Atrial Thrombosis in Stroke Patients With Atrial Fibrillation Open
Atrial fibrillation (AF) and patent foramen ovale (PFO) are potential causes of stroke. [1]2][3] When a patient has both AF and PFO, the risk of stroke/thromboembolism from one of these conditions may be affected by the other. 4 However, t…
View article: Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke
Intensive vs Conventional Blood Pressure Lowering After Endovascular Thrombectomy in Acute Ischemic Stroke Open
Importance Optimal blood pressure (BP) control after successful reperfusion with endovascular thrombectomy (EVT) for patients with acute ischemic stroke is unclear. Objective To determine whether intensive BP management during the first 24…
Association of clot ultrastructure with clot perviousness in stroke patients Open
Clot perviousness on computerized tomography (CT) is predictive of response to reperfusion therapy. This study aimed to determine the association of clot perviousness with ultrastructural features of clot in stroke patients undergoing endo…
Corrigendum: Clinical implications of atrial fibrillatioN detection using wearabLE devices in patients with cryptogenic stroke (CANDLE-AF) trial: Design and rationale Open
[This corrects the article DOI: 10.3389/fcvm.2022.837958.].