Julian Hirt
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View article: Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study
Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study Open
Objective To compare treatment effects from trials designed as decentralised trials or as traditional non-decentralised trials. Design Meta-epidemiological study. Data source PubMed database. Eligibility criteria Trials identified as decen…
View article: Non-pharmaceutical interventions for persons living with young-onset dementia and their informal caregivers: a systematic review with meta-analysis
Non-pharmaceutical interventions for persons living with young-onset dementia and their informal caregivers: a systematic review with meta-analysis Open
To investigate the effects of non-pharmaceutical interventions for persons living with young-onset dementia (YOD) including frontotemporal dementia and their informal caregivers, we conducted a systematic review including randomized and no…
View article: Nonregistration, Discontinuation, and Nonpublication of Randomized Trials
Nonregistration, Discontinuation, and Nonpublication of Randomized Trials Open
Importance Previous work found that 25% to 30% of randomized clinical trials (RCTs) with protocols approved in 2012 or between 2000 and 2003 were discontinued prematurely, most commonly due to inadequate participant recruitment. To minimiz…
View article: Clinical study report data did not substantially alter point estimates but improved precision in a nephrology systematic review
Clinical study report data did not substantially alter point estimates but improved precision in a nephrology systematic review Open
When researchers want to understand how well a treatment works, they often combine results from several clinical studies in a process called a meta-analysis. Usually, these analyses rely on data published in scientific journals. However, p…
View article: Subjektive Gesundheit von Notfallpflegefachpersonen – eine Querschnittstudie
Subjektive Gesundheit von Notfallpflegefachpersonen – eine Querschnittstudie Open
Zusammenfassung Hintergrund Internationale Studien zeigen, dass Notfallpflegefachpersonen (NPF) Stressoren ausgesetzt sind, die sich negativ auf ihre Gesundheit auswirken. Zielsetzung Das Ziel der Studie war, den selbst eingeschätzten Gesu…
View article: Translation and validation of a geographic search filter to identify studies about Germany in Embase (Ovid) and MEDLINE(R) ALL (Ovid)
Translation and validation of a geographic search filter to identify studies about Germany in Embase (Ovid) and MEDLINE(R) ALL (Ovid) Open
We developed a geographic search filter for retrieving studies about Germany from PubMed. In this study, we aimed to translate and validate it for use in Embase and MEDLINE(R) ALL via Ovid. Adjustments included aligning PubMed field tags w…
View article: Data Extractions Using a Large Language Model (Elicit) and Human Reviewers in Randomized Controlled Trials: A Systematic Comparison
Data Extractions Using a Large Language Model (Elicit) and Human Reviewers in Randomized Controlled Trials: A Systematic Comparison Open
Aim We aimed at comparing data extractions from randomized controlled trials by using Elicit and human reviewers. Background Elicit is an artificial intelligence tool which may automate specific steps in conducting systematic reviews. Howe…
View article: Metaresearch on patient-reported outcomes in trial protocols and results publications suggested large outcome reporting bias
Metaresearch on patient-reported outcomes in trial protocols and results publications suggested large outcome reporting bias Open
Less than half of RCT protocols with planned PROs reported them as specified in corresponding published results, suggesting outcome reporting bias, and PRO reporting quality was often deficient. These limitations complicate informed decisi…
View article: Applying qualitative comparative analysis in a systematic review: Lessons learned
Applying qualitative comparative analysis in a systematic review: Lessons learned Open
QCA may increase knowledge gain in systematic reviews by capturing the complexity of interventions and contexts. An adequate dataset is needed to enable systematic comparison. To achieve this, adherence to frameworks guiding the developmen…
View article: Machine-learning assisted screening for evidence synthesis: Methodological case study of the ASReview tool
Machine-learning assisted screening for evidence synthesis: Methodological case study of the ASReview tool Open
ASReview is a software that can potentially reduce the workload of literature screening in systematic reviews by ranking the retrieved records. We assessed the tool’s feasibility, advantages, and limitations, to populate a database of canc…
View article: Machine-Learning Assisted Screening for Evidence Synthesis: A Case Study of Using the ASReview Tool
Machine-Learning Assisted Screening for Evidence Synthesis: A Case Study of Using the ASReview Tool Open
View article: How to search for evidence to answer clinical questions: pragmatic guidance for healthcare professionals and biomedical researchers
How to search for evidence to answer clinical questions: pragmatic guidance for healthcare professionals and biomedical researchers Open
Healthcare professionals, such as medical doctors, nurses, and physiotherapists commit to lifelong learning and to provide evidence-based healthcare. Despite this, surveys have found that medical doctors’ ability to find, analyse, and inte…
View article: Use and application of geographical restrictions in systematic reviews with the aim of including studies about Germany: An update of a methodological review
Use and application of geographical restrictions in systematic reviews with the aim of including studies about Germany: An update of a methodological review Open
Background In systematic reviews (SRs), geographical limitations in literature searches can aid in focussing research efforts. A methodological review published in 2016 examined the approaches SR authors use to identify studies about Germa…
View article: Publicly available continuously updated topic specific databases of randomised clinical trials: A scoping review
Publicly available continuously updated topic specific databases of randomised clinical trials: A scoping review Open
Conducting systematic reviews of clinical trials is arduous and resource consuming. One potential solution is to design databases that are continuously and automatically populated with clinical trial data from harmonised and structured dat…
View article: Involvement of family caregivers in dementia care research: a scoping review protocol
Involvement of family caregivers in dementia care research: a scoping review protocol Open
View article: The optimal approach for retrieving systematic reviews was achieved when searching MEDLINE and Epistemonikos in addition to reference checking: a methodological validation study
The optimal approach for retrieving systematic reviews was achieved when searching MEDLINE and Epistemonikos in addition to reference checking: a methodological validation study Open
Background Systematic reviews (SRs) are used to inform clinical practice guidelines and healthcare decision making by synthesising the results of primary studies. Efficiently retrieving as many relevant SRs as possible is challenging with …
View article: Development and validation of a geographic search filter for <scp>MEDLINE</scp> (<scp>PubMed</scp>) to identify studies about Germany
Development and validation of a geographic search filter for <span>MEDLINE</span> (<span>PubMed</span>) to identify studies about Germany Open
While geographic search filters exist, few of them are validated and there are currently none that focus on Germany. We aimed to develop and validate a highly sensitive geographic search filter for MEDLINE (PubMed) that identifies studies …
View article: Exploring the Experiences of Times Without Care and Encounters in Persons With Dementia in the Swiss and German Nursing Home and Domiciliary Care Settings: Protocol for an Ethnographic Multimethods Study
Exploring the Experiences of Times Without Care and Encounters in Persons With Dementia in the Swiss and German Nursing Home and Domiciliary Care Settings: Protocol for an Ethnographic Multimethods Study Open
Background Persons with dementia spend a large part of the day without care and encounters, often without activity, as confirmed by numerous studies. However, no scientific analysis has examined how persons with dementia experience these p…
View article: Benchmarking Human–AI collaboration for common evidence appraisal tools
Benchmarking Human–AI collaboration for common evidence appraisal tools Open
Current LLMs alone appraised evidence worse than humans. Human-AI collaboration may reduce workload for the second human rater for the assessment of reporting (PRISMA) and methodological rigor (AMSTAR) but not for complex tasks such as PRE…
View article: Introducing a unique animal <scp>ID</scp> and digital life history museum for wildlife metadata
Introducing a unique animal <span>ID</span> and digital life history museum for wildlife metadata Open
Over the past five decades, a large number of wild animals have been individually identified by various observation systems and/or temporary tracking methods, providing unparalleled insights into their lives over both time and space. Howev…
View article: Delphi studies in social and health sciences—Recommendations for an interdisciplinary standardized reporting (DELPHISTAR). Results of a Delphi study
Delphi studies in social and health sciences—Recommendations for an interdisciplinary standardized reporting (DELPHISTAR). Results of a Delphi study Open
Background While different proposals exist for a guideline on reporting Delphi studies, none of them has yet established itself in the health and social sciences and across the range of Delphi variants. This seems critical because empirica…
View article: Comparing different scoping and mapping review methodologies: A practical example using the nursing mobile workstation
Comparing different scoping and mapping review methodologies: A practical example using the nursing mobile workstation Open
Aims To provide (1) an overview of core characteristics of scoping and mapping review methodologies and (2) to illustrate the differences and similarities of these methodologies using literature on nursing mobile workstations. Design Syste…
View article: Reply to Commentary to Skudlik et al. (2023): why a scoping review and why only Germany?
Reply to Commentary to Skudlik et al. (2023): why a scoping review and why only Germany? Open
View article: Guidance on terminology, application, and reporting of citation searching: the TARCiS statement
Guidance on terminology, application, and reporting of citation searching: the TARCiS statement Open
Evidence syntheses adhering to systematic literature searching techniques are a cornerstone of evidence based healthcare. Beyond term based searching in electronic databases, citation searching is a prevalent search technique to identify r…
View article: Rationale and design of the Cancer Immunotherapy Evidence Living (CIEL) Library: A continuously updated clinical trial database of cancer immunotherapies
Rationale and design of the Cancer Immunotherapy Evidence Living (CIEL) Library: A continuously updated clinical trial database of cancer immunotherapies Open
Background Immunotherapies for cancers are being tested in large numbers of clinical trials. It is nearly impossible for clinicians and researchers to stay current with the evidence, and traditional systematic reviews and clinical guidelin…
View article: Benchmarking Human-AI Collaboration for Common Evidence Appraisal Tools
Benchmarking Human-AI Collaboration for Common Evidence Appraisal Tools Open
Background It is unknown whether large language models (LLMs) may facilitate time- and resource-intensive text-related processes in evidence appraisal. Objectives To quantify the agreement of LLMs with human consensus in appraisal of scien…
View article: Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis
Clinical trial evidence of quality-of-life effects of disease-modifying therapies for multiple sclerosis: a systematic analysis Open
Background Increasingly, patients, clinicians, and regulators call for more evidence on the impact of innovative medicines on quality of life (QoL). We assessed the effects of disease-modifying therapies (DMTs) on QoL in people with multip…
View article: Definitions of digital biomarkers: a systematic mapping of the biomedical literature
Definitions of digital biomarkers: a systematic mapping of the biomedical literature Open
Background Technological devices such as smartphones, wearables and virtual assistants enable health data collection, serving as digital alternatives to conventional biomarkers. We aimed to provide a systematic overview of emerging literat…
View article: Evidenzbasierte Praxis in Bachelor-Pflegestudiengängen in Österreich, Deutschland und der Schweiz: ein Survey zu Rahmenbedingungen, Lehrinhalten und -methoden
Evidenzbasierte Praxis in Bachelor-Pflegestudiengängen in Österreich, Deutschland und der Schweiz: ein Survey zu Rahmenbedingungen, Lehrinhalten und -methoden Open
Topics on evidence-based practice are an integral part of bachelor's degree programs in nursing in German-speaking countries. An increase in teaching units, active learning methods and the growing interconnection between education and prac…
View article: Development and validation of a geographic search filter for MEDLINE (PubMed) to identify studies conducted in Germany
Development and validation of a geographic search filter for MEDLINE (PubMed) to identify studies conducted in Germany Open
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