Pieter J. Hoekstra
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View article: Linking genetics to behavior: from glutamatergic genetic variation via amygdala morphology and fear recognition to youth’s callous-unemotional traits and reactive-proactive aggression
Linking genetics to behavior: from glutamatergic genetic variation via amygdala morphology and fear recognition to youth’s callous-unemotional traits and reactive-proactive aggression Open
Our results suggest that 1) glutaminergic genetic variation is associated with CU traits, 2) glutamatergic genetic variation is associated with amygdala volume and fear recognition, and 3) indirectly with CU traits through fear recognition…
View article: Persistent Tic Disorders Are Associated With 17q12 Duplications
Persistent Tic Disorders Are Associated With 17q12 Duplications Open
Tourette Syndrome (TS) and Persistent Tic Disorder (PTD) are childhood-onset neuropsychiatric conditions with high heritability. Due to current sample size limitations, identifying TS/PTD risk genes has been challenging. This study address…
View article: Research Review: Mechanisms of change and between‐family differences in parenting interventions for children with ADHD – an individual participant data meta‐analysis
Research Review: Mechanisms of change and between‐family differences in parenting interventions for children with ADHD – an individual participant data meta‐analysis Open
Background Understanding the mechanisms of change and between‐family differences in behavioural parenting interventions for children with attention‐deficit/hyperactivity disorder (ADHD) may help personalise interventions. Therefore, we exa…
View article: Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data
Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data Open
Background Economic evaluations of treatments for children with behavioural difficulties (i.e., characteristics of attention‐deficit/hyperactivity disorder (ADHD) and/or oppositional defiant disorder (ODD)) usually rely on data of randomis…
View article: Parent Training for Disruptive Behaviors in Referred Children with Autism Spectrum Disorder: A Randomized Controlled Trial
Parent Training for Disruptive Behaviors in Referred Children with Autism Spectrum Disorder: A Randomized Controlled Trial Open
The purpose of this study was to investigate whether face-to-face and therapist-assisted online (i.e., blended) behavioral parent training are effective on reducing disruptive behaviors in children with autism spectrum disorder (ASD) in ro…
View article: Predictive validity of the Standardized Infant NeuroDevelopmental Assessment (SINDA) to identify 4–5 year-old children at risk of developmental delay in a low-risk sample
Predictive validity of the Standardized Infant NeuroDevelopmental Assessment (SINDA) to identify 4–5 year-old children at risk of developmental delay in a low-risk sample Open
In low-risk infants, SINDA's predictive value is low for detecting children at risk of marked and any developmental delay at 4-5 years, as reflected by the low sensitivities. One of the explanations is the relatively low prevalence of deve…
View article: Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group
Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group Open
Academy of Medical Sciences and Economic and Social Research Council.
View article: <scp>ADHD</scp> medication adherence reduces risk of committing minor offenses in adolescents
<span>ADHD</span> medication adherence reduces risk of committing minor offenses in adolescents Open
Background This study aimed to investigate the association between adolescents’ adherence to attention‐deficit/hyperactivity disorder (ADHD) medication and their risk of committing minor offenses. Methods Using two Dutch databases, Statist…
View article: The Short- and Longer-Term Effects of Brief Behavioral Parent Training Versus Care as Usual in Children with Behavioral Difficulties: Study Protocol for a Randomized Controlled Trial
The Short- and Longer-Term Effects of Brief Behavioral Parent Training Versus Care as Usual in Children with Behavioral Difficulties: Study Protocol for a Randomized Controlled Trial Open
Background The access to and uptake of evidence-based behavioral parent training for children with behavioral difficulties (i.e., oppositional, defiant, aggressive, hyperactive, impulsive, and inattentive behavior) are currently limited be…
View article: Patterns of mental disorders in a nationwide child psychiatric sample (<i>N</i>=67,815): A DREAMS study
Patterns of mental disorders in a nationwide child psychiatric sample (<i>N</i>=67,815): A DREAMS study Open
Objective To provide a comprehensive overview of the prevalence and comorbidity patterns of mental disorders in a large, nationwide child and adolescent psychiatry sample. Methods We retrieved data on DSM diagnoses from medical records of …
View article: Changes in child and adolescent mental health across the COVID‐19 pandemic (2018–2023): Insights from general population and clinical samples in the Netherlands
Changes in child and adolescent mental health across the COVID‐19 pandemic (2018–2023): Insights from general population and clinical samples in the Netherlands Open
Background The COVID‐19 pandemic negatively affected child and adolescent mental health and at the end of the pandemic (April 2022) child mental health had not returned to pre‐pandemic levels. We investigated whether this observed increase…
View article: Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD
Rare X-linked variants carry predominantly male risk in autism, Tourette syndrome, and ADHD Open
Autism spectrum disorder (ASD), Tourette syndrome (TS), and attention-deficit/hyperactivity disorder (ADHD) display strong male sex bias, due to a combination of genetic and biological factors, as well as selective ascertainment. While the…
View article: Suicidality Treatment Occurring in Paediatrics (STOP) Medication Suicidality Side Effects Scale in young people in two cohorts across Europe
Suicidality Treatment Occurring in Paediatrics (STOP) Medication Suicidality Side Effects Scale in young people in two cohorts across Europe Open
Objectives As part of the ‘Suicidality: Treatment Occurring in Paediatrics (STOP)’ study, we developed and performed psychometric validation of an electronic-clinical-outcome-assessment (eCOA), which included a patient-reported-outcome (eP…
View article: Effects of positive behaviour support delivered by direct staff on challenging behaviours and quality of life of adults with intellectual disabilities: A multicentre cluster‐controlled trial
Effects of positive behaviour support delivered by direct staff on challenging behaviours and quality of life of adults with intellectual disabilities: A multicentre cluster‐controlled trial Open
Background Effects of staff provided positive behaviour support (PBS) for individuals with intellectual disabilities are unclear. Method Using a multicentre non‐randomised cluster controlled design, 26 teams of residential group homes, inc…
View article: Results of N=1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials embedded in clinical practice after longer term methylphenidate use: A pilot study
Results of N=1 randomized, double-blind, placebo-controlled, cross-over discontinuation trials embedded in clinical practice after longer term methylphenidate use: A pilot study Open
Background Attention-deficit/hyperactivity (ADHD) guidelines recommend that the need for continued stimulant medication treatment of children and adolescents needs to be reviewed at least annually. We aimed to assess the outcomes in clinic…
View article: Sustained improvements by behavioural parent training for children with attention‐deficit/hyperactivity disorder: A meta‐analytic review of longer‐term child and parental outcomes
Sustained improvements by behavioural parent training for children with attention‐deficit/hyperactivity disorder: A meta‐analytic review of longer‐term child and parental outcomes Open
Background Behavioural parent training is an evidence‐based intervention for children with attention‐deficit/hyperactivity disorder (ADHD), but little is known about the extent to which initial benefits are maintained. Aims This meta‐analy…
View article: Changes in child and adolescent mental health across the COVID-19 pandemic (2018-2023): Insights from general population and clinical samples in the Netherlands
Changes in child and adolescent mental health across the COVID-19 pandemic (2018-2023): Insights from general population and clinical samples in the Netherlands Open
Background The COVID-19 pandemic negatively affected child and adolescent mental health and at the end of the pandemic (April 2022) child mental health had not returned to pre-pandemic levels. We investigated whether this observed increase…
View article: Difficulties in Addressing Diagnostic, Treatment and Support Needs in Individuals with Intellectual Disability and Persistent Challenging Behaviours: A Descriptive File Study of Referrals to an Expertise Centre
Difficulties in Addressing Diagnostic, Treatment and Support Needs in Individuals with Intellectual Disability and Persistent Challenging Behaviours: A Descriptive File Study of Referrals to an Expertise Centre Open
Service providers may experience difficulties in providing appropriate care to optimize the functioning of individuals with intellectual disability and challenging behaviour. External consultation to identify and address the unmet support …
View article: Short-term effects of an elimination diet and healthy diet in children with attention-deficit/hyperactivity disorder: a randomized-controlled trial
Short-term effects of an elimination diet and healthy diet in children with attention-deficit/hyperactivity disorder: a randomized-controlled trial Open
An Elimination Diet (ED) may be effective in reducing symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), but has never been compared to an active control condition [i.e., Healthy Diet (HD)]. In a two-armed RCT, a total of N = 165…